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Adefovir Meyer is a prescription drug used to treat hepatitis B virus infection. Besides the effective use of the drug, patients should also be aware of the unwanted side effects that the drug causes.
1. What is Adefovir Meyer?
Adefovir Meyer has the main ingredient is Adefovir dipivoxil 10 mg, belongs to the group of antiparasitic, anti-infective, antiviral, antifungal drugs, used in the treatment of chronic hepatitis B virus infection in adults when present hepatitis B virus replication.
Mechanism of action:
Adefovir Meyer has the same main ingredient as a nucleotide compound, which works by slowing the growth of the virus, helping to reduce the amount of virus in the patient's body. Adefovir Meyer is not a cure for hepatitis B and does not prevent the transmission of hepatitis B to others.
2. Dosage and how to take Adefovir Meyer
Usage : The drug is prepared in the form of film-coated tablets and is used orally. For the drug to be absorbed quickly and effectively, the patient should take it during or after a meal.
Dosage: The dosage of the drug in the treatment of chronic hepatitis B is 1 tablet/day.
For patients with liver failure: Apply the same dosage as for normal people, because according to clinical studies, it is proven in patients with non-chronic hepatitis B that have impaired liver function when taking the drug. Since the pharmacokinetics of Adefovir Meyer are not altered, it is not necessary to change the dose of adefovir in these cases.
Patients with renal impairment : Need to change the dose depending on the renal clearance, specifically as follows:
Creatinine clearance from 20 to 49 ml/min using 10 mg/48 hours. Creatinine clearance from 10 to 19 ml/min administered at a dose of 10 mg/72 hours. For patients on hemodialysis, a dose of 10 mg is given every 7 days after dialysis or after cumulative dialysis for a total of 10 hours.
3. Overdose and how to handle it
When using an overdose of Adefovir Meyer, patients may experience symptoms such as loss of appetite, anorexia and digestive disorders.
How to handle: Patients should inform their doctor or pharmacist about their condition. In some cases of drug overdose and severe reactions, the patient will be used by the doctor by hemodialysis, the average clearance is 104 ml / min to remove Adefovir Meyer from the body.
4. Side effects of Adefovir Meyer
Some unwanted side effects when using the drug:
Affect the digestive system with manifestations such as abdominal pain, nausea, flatulence, diarrhea, indigestion. Affects the nervous system with the most common symptom being headache. Affects the whole body with asthenic manifestations. Some other reactions such as itching, skin rash, effects on the respiratory system include coughing with frequency, pharyngitis and sinusitis. Effects on kidney and liver function include: increased serum creatinine, kidney damage, acute renal failure, and elevated liver enzyme levels. Effects on renal and urinary function include: renal failure, fanconi syndrome, proximal tubule disease.
5. Precautions when using Adefovir Meyer
Treatment with adefovir should be discontinued if aminotransferase levels in the body increase rapidly, hepatomegaly is in progress or have fatty liver disease, lactic acidosis of unknown cause. Caution should be exercised when adefovir is used in patients with hepatomegaly or other risk factors for liver disease. Careful distinction should be made between patients with elevated liver enzyme levels due to response to therapy and toxicity. In many patients, a more severe development of hepatitis has been observed after discontinuation of adefovir therapy. Therefore, liver function should be closely monitored periodically throughout the time after the patient has stopped taking adefovir. Patients with renal failure after taking the drug should be regularly monitored for problems related to kidney function monthly. Special care should be taken in patients with creatinine clearance less than 50 ml/min (dosage adjustment is required as needed) and who are taking other medications with adverse effects on renal function. For HIV resistance: Before starting treatment with Adefovir Meyer, it is necessary to check for HIV antibodies in the patient. Use with caution in patients under 18 years of age and patients over 65 years of age. For pregnant women: There are no adequate studies to confirm that the drug is safe for pregnant women and these studies are limited. Therefore, doctors recommend that the drug should not be used during pregnancy, unless absolutely necessary and with careful consideration of the risks and benefits of taking the drug. Lactation: It is not known whether Adefovir is excreted in human milk. Before using the drug, consult your doctor.
6. Drug interactions
When combined with antiviral drugs Adefovir Meyer can lead to cases of lactic acidosis and fatty liver disease, more serious cases have been recorded.
Abacavir, Acetaminophen: Co-administration with Adefovir dipivoxil may decrease the rate of excretion of the above drugs, which leads to higher serum concentrations. Aceclofenac, Acetylsalicylic Acid : The risk or severity of kidney toxicity may be increased when Adefovir dipivoxil is combined with these 2 drugs. Acemetacin: The risk or severity of nephrotoxicity may be increased when Adefovir dipivoxil is combined with Acemetacin. Acetaminophen: Adefovir dipivoxil may decrease the rate of excretion of Acetaminophen, which may lead to higher serum concentrations in the body. Vaccine containing live adenovirus type 7 : The therapeutic efficacy of Adenovirus vaccine may be reduced when used in combination with Adefovir dipivoxil. Albutrepenonacog alfa: Adefovir dipivoxil may decrease the rate of excretion of Albutrepenonacog alfa, which may lead to higher serum concentrations. Alendronic Acid: The risk or severity of nephrotoxicity and hypocalcemia may be increased when Adefovir dipivoxil is combined with alendronic acid. Alprostadil: Alprostadil excretion may be reduced when combined with Adefovir dipivoxil. Aminohippuric acid: The excretion of Adefovir dipivoxil may be reduced when combined with Aminohippuric acid Anthrax vaccine : The therapeutic efficacy of anthrax vaccine may be reduced when used in combination with Adefovir dipivoxi. Adefovir Meyer is a prescription medicine used to treat hepatitis B virus infection. To ensure effective treatment and avoid unwanted side effects, patients should strictly follow the doctor's instructions, specialist pharmacist.
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