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Actonel 75mg and actonel 35mg are indicated for the prevention and treatment of osteoporosis in adults. On the market today, there is a lot of information about actonel drug products, but it is still incomplete. To better understand what actonel is, what are the uses of actonel, let's learn more in the article below.
1. What is actonel 75mg and actonel 35mg?
Actonel 75mg and actenel 35mg are drugs that affect bone metabolism, the main ingredient is risedronate sodium. Risedronate sodium is a pyridyl bisphosphonate bound to bone hydroxyapatite that inhibits bone-mediated bone resorption, as an anti-osteoporotic agent.
Absorption of actonel: Actonel is absorbed fairly rapidly about 1 hour after oral administration, independent of dose. When taken orally, the mean bioavailability is 0.63%. If actonel is taken with food, bioavailability is reduced. Bioavailability in men and women is similar. Distribution of actonel: At steady state in humans, the volume of distribution is 6.3 liters/kg. The drug is bound to plasma proteins, accounting for about 24%. Actonel drug metabolism: There are no studies with evidence of systemic metabolism for actonel. Elimination of actonel: Within 24 hours, approximately half of the absorbed dose of actonel is excreted in the urine. The remaining unabsorbed actonel is eliminated as unchanged drug in the faeces.
2. What are the uses of Actonel 75mg and actonel 35mg?
Actonel 75mg and actonel 35mg have the effect of treating and preventing osteoporosis in adults. Osteoporosis, which makes bones thinner and more prone to fracture, progresses more rapidly with age or after menopause, or perhaps long-term use of corticosteroids can also cause osteoporosis. Actonel has risedronate ingredient that works to slow down bone loss, directly acting on bones to make bones stronger, reducing the possibility of fractures. Actonel is also used to increase bone mass in men with osteoporosis and to treat Paget's disease of the bones in men and women.
3. How to use actonel effectively?
3.1. How to take – dosage Use the medicine as directed by your doctor or pharmacist. Here is the dosage for your reference:
The usual dose for osteoporosis is 5mg per day, one Actonel 35mg tablet for 7 days, one actonel 75mg for 15 days. The usual dose for paget's disease of bone is 30mg/day for 2 months Actonel tablets come in different strengths (milligrams per tablet) given in different dosages. Depending on why you have to take Actonel and the strength of each tablet, your dosage will also vary. It may be necessary to take 1 tablet once daily, once weekly, once monthly, or for 2 consecutive days once per month. Use Actonel exactly as directed. Risedronate is usually only used for 3 to 5 years.
Take actonel first thing in the morning with a glass of water, take it at least 30 minutes before you eat or drink anything or take any other medicine.
Take Actonel tablets only with water. Do not use any other water such as coffee, tea, soda, juice or mineral water.
Do not crush, chew or suck on the tablet. Swallow the pill.
After taking Actonel tablets, wait at least 30 minutes:
Before you lie down or recline. Can stand, sit or walk or perform normal activities such as reading. Before you eat or drink anything, except water. Before you take any other medicines including vitamins, calcium, iron, antacids or laxatives. Take actonel on the same schedule as at the same time of day, or on the same day of the week, or on the same day of the month. When using the drug, it is necessary to pay attention to oral hygiene. You need to clean your teeth regularly. If you do any work with your teeth, tell your doctor that you are using Actonel.
Actonel is just one of the treatments for osteoporosis. In addition, patients need to change their diet, exercise, check bone mineral density, increase vitamin and calcium supplements. Follow your doctor's instructions tightly.
Store at room temperature, in a cool, dry place, away from moisture and heat. Keep the unused tablet in the original blister pack.
Contraindications of Actonel 75mg and actonel 35mg: Do not use the drug if you are sensitive to any of its ingredients.
If you have problems with the esophagus or low blood calcium levels, do not use actonel.
If you cannot sit upright or stand for at least 30 minutes after taking the medicine, the medicine should not be used.
Actonel can cause serious problems in the stomach or esophagus. If you have new or worsening chest pain, heartburn, or pain when swallowing, stop using this medicine and tell your doctor right away.
If you have muscle spasms, numbness or tingling (in your hands and feet or around your mouth), new or unusual hip pain, or severe pain in your joints, bones or muscles call your doctor right away. doctor or go to the nearest medical facility.
What to do if you miss a dose? Dose once a day: If you take the medicine in the morning, skip the usual dose and wait until the next morning to take the next dose, do not take the medicine after the missed time, do not take 2 doses in 1 day .
Once a week or once a month dose: If you forget to take Actonel on the scheduled day, take it the first time in the morning of the day after you remember the missed dose. Then, return to your usual weekly or monthly schedule on your chosen dosage date. Do not take 2 doses in one day.
Call your doctor for instructions if you miss more than 2 doses in a month.
What to do if overdose? An overdose of actonel can lead to a decrease in serum calcium and phosphorus in some patients. In addition, hypocalcaemia may also occur in some other patients. Please drink a full glass of milk or go to the nearest medical facility for timely treatment.
3.2. Actonel side effects Tell your doctor or nearest medical facility if you have signs of an allergic reaction to Actonel such as hives, difficulty breathing, swelling in your face or throat, or a reaction. severe skin reactions such as high fever, sore throat, burning in the eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
If you have the following symptoms, stop taking the medicine and tell your doctor right away:
New or worsening chest pain, heartburn; Difficult or painful swallowing; Pain or burning under the ribs or in the back; severe heartburn, burning pain in your upper abdomen, or coughing up blood; New or unusual pain in your thigh or hip; Jaw pain, numbness, or swelling; Severe joint, bone, or muscle pain; or Low calcium levels--muscle spasms or spasms, numbness or tingling (around the mouth, or in the fingers and toes). Some common side effects of Actonel may include:
sourness, diarrhea, indigestion; Stomachache; Back pain, joint pain, muscle pain; or Flu-like symptoms. This is not a complete list of side effects, tell your doctor if you experience other side effects.
3.3. Drug interactions with actonel Tell your doctor about all medicines you are taking or any medicines you are about to take or stop using, especially the following medicines:
Aspirin ; Calcium or iron supplements; Antacids, laxatives; or an NSAID (nonsteroidal anti-inflammatory drug)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not exhaustive. Other drugs may interact with risedronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Talk to your doctor about the best dosing schedule for your other medications
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