This is an automatically translated article.
Zedcal op drug contains active ingredient calcium carbonate B.P equivalent to elemental calcium along with other active ingredients such as zinc... The drug is effective for osteoporosis caused by prolonged hypocalcemia, as well as absorption Poor calcium absorption leads to disturbances in calcium metabolism and decreased production of active vitamin D3. This article will provide more information about this drug.
1. Pharmacodynamics of Zedcal op
How does the drug zedcal-op affect the body? In the body, the calcium content is mainly concentrated in the bones, accounting for 99%. Therefore, this compound is essential for preserving bone mass and density. When the body is deficient in calcium due to an unhealthy diet or diet, it can lead to a decrease in bone strength and cause a number of risk factors related to diseases such as osteoporosis. In addition, zinc is also an essential component for the biosynthesis of the matrix protein of bone cells. And the base site of bone cells is also the place where calcium, phosphorus and other minerals attach here. Zinc deficiency is quite common in people with weak bones.
Calcitriol - the active metabolite of vitamin D3 helps to regulate the normal intestinal absorption of calcium and bone mineralization. With a sufficient amount of vitamin D3 can be easily converted into calcitriol. But in some cases causes a decrease in endogenous production along with signs and symptoms of bone-related diseases resulting in pathologies due to disturbances in calcium absorption or homeostasis. or metabolism in the body.
2. Pharmacokinetics in Zedcal op
Calcium carbonate compounds are converted to calcium chloride compounds through gastric acid and are absorbed mainly from the small intestine. Then, it will be eliminated through the body's feces, urine and sweat.
In addition, the composition of Zedcal op contains zinc and is absorbed mainly from the duodenum. After absorption, it will be excreted mainly in the feces. And a fairly small amount of zinc will be excreted in the urine. Calcitriol is rapidly absorbed from the intestine with a single dose of 0.25 to 1 mcg of calcitriol, serum concentrations of calcitriol are elevated and maximal levels are reached within 3 to 6 hours. Calcitriol and other metabolites of vitamin D will perform binding to specific plasma proteins in the transport of these substances in the blood. Calcitriol of exogenous origin will cross the placental barrier and will be excreted into breast milk. In addition, calcitriol is also excreted in the bile.
Thuốc Zedcal op có tác dụng đối với bệnh loãng xương
3. Indications and dosage of Zedcal op
The drug Zedcal op is used in the form of tablets and compresses to be taken with the main meal. However, when using the patient should not chew or drink on an empty stomach.
The drug Zedcal op is indicated in the case of osteoporosis, especially for those with osteoporosis after menopause with a dose of 1 tablet used twice a day.
Diseases caused by prolonged calcium deficiency, poor absorption of calcium into the intestinal tract or disorders of calcium metabolism in the body due to a decrease in the production of active vitamin D3. Specify the initial dose of 1 tablet and use it for one day or one tablet for 2 days. During use and monitoring, if necessary, the dose of zedcal op can be increased gradually about every 2 -4 weeks until the maximum dose is 1 tablet once and used 3 times a day.
Pathological conditions of osteoporosis due to kidney disease in patients with chronic renal failure especially those in patients on hemodialysis. Prescribe an initial dose of 1 tablet per day or 1 tablet for 2 days and will gradually increase the dose as needed.
Cases with hypoparathyroidism due to post-operative or idiopathic or possibly sham disease, the initial indication is to take 1 tablet a day in the morning. Continue monitoring and increase the maximum dose to three tablets a day for children and four tablets a day for adults.
In cases of vitamin D resistance, poor metabolism, nutritional rickets, osteomalacia or vitamin D dependent rickets, an initial dose of one tablet a day in the morning may be indicated and the dose may be increased gradually. up to a maximum dose of 3 tablets a day in children and 4 tablets a day in adults.
Dosage as indicated above is for reference only. Therefore, if you need to use drug treatment, you need to see a doctor and follow the doctor's prescription. Because each patient will have a specific dose, because each person will have different health and disease levels.
4. Some cases to note when using Zedcal op
Zedcal op medicine can be used in the treatment of micronutrient deficiencies of calcium and zinc.. However, with some specific cases, it should be noted when using this drug, including: pregnant women and women breastfeeding women. Although there is no conclusive evidence of the effects of calcitriol of exogenous origin on pregnancy or fetal development, caution should be exercised in these populations. Or the drug is not used for a long time with children, especially very cautious when using the drug for children under 3 years old. In addition, in cases of patients, it is recommended to monitor plasma calcium or phosphorus, magnesium and alkaline phosphatase. Or the patient is taking digitalis, as drug absorption will be reduced by the digitalis component. Or do not use together with other drugs containing ingredients of vitamin D.
In addition, the drug is also limited to cases of hypersensitivity to the ingredients of the drug or cases of hypercalcemia or cases of signs toxic components of vitamin D.
The compounds in Zedcal op are well tolerated in the body. However, when used in excess of the prescribed dose, it can lead to hypercalcemia or hypercalciuria. In case of overdose, the patient should stop using and notify the doctor to find a solution. Or in case of an emergency, the patient needs to call an ambulance or take the patient to the nearest medical facility.
During the course of treatment using Zedcal op, if a dose is missed, the patient should take the missed dose as soon as possible. However, if it is almost time for the next dose, the patient can skip the missed dose and continue with the next dose. Patients should note that when a dose is missed, do not try to take a double dose than prescribed.
Người bệnh nên thận trọng khi sử dụng thuốc Zedcal op
5. Unwanted side effects when using Zedcal op
When using Zedcal op, patients may experience unwanted side effects. At the minimum dose, Zedcal op is recommended to be well tolerated by the body. However, if side effects do occur, some symptoms may include feeling weak, dizzy, headache or dry mouth or nausea or being constipated or having muscle pain or a metallic taste in the mouth. type. In the case of side effects, but signs appear later may lead to the patient urinating a lot, thirsting a lot or the patient will have anorexia, photophobia or conjunctivitis or runny nose...
When If you experience unwanted side effects while using the drug, you should contact your doctor for timely advice. Zedcal is used to treat osteoporosis caused by prolonged hypocalcemia, as well as poor calcium absorption leading to calcium metabolism disorders and reduced production of active vitamin D3. To ensure effective use and avoid side effects, patients need to take the drug according to prescription or consult a doctor or pharmacist.
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