The effects of Spulit

This is an automatically translated article.

1. Effects of Spulit

Spulit medicine has the main ingredient Itraconazole 100mg, is made in the form of capsules. Itraconazole is a synthetic triazole with antifungal activity. The drug works better than ketoconazole against some fungi, especially against aspergillus spp. The mechanism of action of Itraconazole is inhibition of fungal cytochrome P450-dependent enzymes, inhibition of ergosterol biosynthesis, and dysfunction of fungal membranes and membrane-bound enzymes. This affects the survival and growth of fungal cells. Spulit drug has the following effects:
Inhibits the growth of fungal cells and helps prevent the spread of fungi on the skin, thereby quickly reducing the symptoms of fungal diseases. It has a broad spectrum of action on many fungi, so it is used to treat ringworm.

2. Indications and contraindications of Spulit

Indications: Oral Spulit is used in the following cases:
Treatment of Candida infections in the mouth, throat, Candida genitalia such as vulva and vagina. Thing of tinea versicolor. Treatment of fungal skin diseases caused by fungi sensitive to itraconazole (such as diseases caused by trichophyton spp, microsporum spp or epidermophyton floccosum): Tinea pedis, inguinal skin, dark skin, interstitial skin. Treatment of fungal diseases of toenails and fingernails. Treatment of blastomyces disease causing disease in the lungs and extrapulmonary. Treatment of histoplasmosis includes chronic lung disease and disseminated histoplasmosis. Treatment of aspergillus-induced pulmonary and extrapulmonary disease in patients intolerant to or resistant to amphotericin B. Maintenance therapy in persons with AIDS to prevent recurrence of latent fungal infections. Prevention of fungal infections during prolonged neutropenia, for which conventional treatments are ineffective Contraindications : Do not use the drug in the following cases:
There is a history of hypersensitivity to itraconazole or with other azoles or any of the excipients in the product. The patient is being treated with drugs such as terfenadine, astemizole, triazolam, oral midazolam and cisapride. Do not use to treat fungal infections in women who are pregnant or planning to become pregnant. Women who are breastfeeding.

3. Dosage and how to use Spulit

How to use: The drug is made in the form of capsules, to be taken orally by drinking directly with water.
Dosage: Depending on the case of fungal infection, the dose is different. You can refer to the dosage below.
Adults for short-term treatment:
Vaginal or vaginal candidiasis: Use a dose of 200 mg once, twice a day and use only 1 day. It is possible to use a dose of 200mg, taken once a day and taken for 3 days. Ringworm: Take 200 mg once and take it once a day for 7 days. Dermatophytosis: Take 100 mg daily for 15 days. Oral and oropharyngeal candidiasis: Oral 100 mg, once a day, for 15 days. Patients with immunodeficiency such as AIDS or neutropenia should take 200mg, once a day, for 15 days (because the drug is poorly absorbed from the gastrointestinal tract in this group, the dose needs to be increased). Adult long-term treatment depending on the patient's response
Onychomycosis: Oral 200 mg, once a day and used for 3 months. Aspergillus: 200 mg, once a day, for 2 to 5 months. The dose can be increased by about 200mg / time, taken 2 times a day, if the fungal infection is widespread. Candidiasis: Use a dose of 100 to 200 mg, orally once a day, for 3 weeks to 7 months. The dose may be increased by 200 mg, twice daily, if the disease is widespread. Cryptococcal disease (without meningitis): 200mg/time, once a day, orally within 2 months to 1 year. Cryptococcal meningitis: 200mg/time, twice a day. Maintenance treatment with a dose of 200mg, taken once a day. Histoplasmosis and Blastomyces: 200mg/time, once or twice a day for 8 months. Maintenance treatment in AIDS patients: 200mg/time, once a day. Prophylaxis of fungal infections in neutropenia: 200 mg/time, once a day. Use maintenance. Children: Efficacy and safety have not been established, so use in children should be limited.
Elderly: Use the same dose as adults.

4. Undesirable effects of the drug Spulit

During the use of the drug, the patient may appear some side effects as follows:
Nausea, abdominal pain, slow digestion, headache. Itching and discomfort in the throat. Allergic reactions may also occur such as pruritus, rash, urticaria and angioedema, Stevens-Johnson syndrome. This is a sign that needs to be treated early, so if it occurs, it is necessary to stop taking the drug and get medical attention as soon as possible. Menstrual disorders. Liver: If used for a short time, there is almost no effect. But it can cause elevated liver enzymes, hepatitis, especially after long-term treatment. When there are unusual signs that are suspected to be related to the use of the drug, you should contact your doctor for timely handling measures.

5. Note when using Spulit

Before taking the medicine you need to inform your doctor about your allergy. Avoid using the drug when it is known that you are allergic to it. Need to monitor liver function during long-term treatment: When short-term treatment, the drug almost does not cause liver dysfunction, but it is also necessary to monitor or not use the drug for people with a history of liver disease or liver disease. Hepatotoxicity caused by other drugs. During long-term treatment for more than 30 days, it is necessary to periodically test liver function. There are no adequate studies on the effects of the drug in pregnant and lactating women. Therefore, minimize the use of drugs and if necessary, consult your doctor before deciding to use the drug on this subject. Because taking the drug can cause dizziness as a side effect, you need to be very careful when operating machinery or vehicles. Drug interactions can occur when certain other drugs are used in combination with this drug. Drugs that can interact such as diazepam, calcium channel blockers, warfarin ... Do not use the drug when there are signs of damage, overdue. Store the medicine in a cool place, away from sunlight. Spulit is a drug that is used under the direction of the treating doctor. Patients should avoid indiscriminate use of drugs when the cause of the fungus has not been determined, to avoid the effects of the drug on health.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.