The effect of the drug Vinsolon 40mg

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1. What is Vinsolon 40mg?

Vinsolon 40mg drug belongs to the list of prescription anti-inflammatory drugs according to the instructions. The main ingredient in Vinsolon 40mg is the active ingredient Methylprednisolone 4mg. In addition, in the drug Vinsolon 40mg there are some other excipients.
Vinsolon 40mg is packed in each box including:
1 box of lyophilized powder; 1 ampoule of solvent (Benzyl alcohol 9mg and distilled water for injection just enough for 1ml); Vinsolon 40mg has a white box with the drug name printed in blue, the remaining words printed with ingredients, content, usage ... printed in black. In addition, on the box of Vinsolon 40mg medicine, there is a picture of the chemical formula of the ingredients in the drug.

2. Uses of Vinsolon 40mg

Vinsolon 40mg drug has the main active ingredient Methylprednisolone - a synthetic glucocorticoid belonging to a 6-alpha - methyl derivative of prednisolone. This active ingredient has the generality of Glucocorticoid prednisolone but is less soluble, difficult to metabolize, but has long-lasting effects.
Glucocorticoids will penetrate cell membranes, binding to specific plasma cell receptors. This complex enters the cell nucleus, binds to DNA, and stimulates the transport of messenger RNA. Glucocorticoids not only affect the inflammatory and immune processes but also have the effect of metabolizing substances such as carbohydrates, proteins, and fats. These substances have effects on parts such as the central nervous system, cardiovascular system, skeletal muscle.
In general, the use of Vinsolon 40mg is to affect the inflammatory and immune processes. Specifically:
2.1. Anti-inflammatory effect Anti-inflammatory ability thanks to the effect of causing the production and release of inflammatory mediators such as Histamine, Prostaglandin, Leucotrien... Therefore, can help improve the expression onset of the inflammatory process.
In addition, Vinsolon 40mg also helps inhibit leukocytes from binding to damaged vessel walls. Move, cling to the injured site and reduce the permeability in that location. Finally, white blood cells can migrate to less damaged areas, reducing vascular activity, swelling, edema, and pain.
2.2. Immunosuppressive Use The immunosuppressive effect of Vinsolon 40mg reduces responses to slow, immediate reactions. The mechanism of immunosuppression is based on inhibiting the action of antigen-antibody complexes that induce allergic vasculitis in the skin.
The effect on Lymphokine, target cells and macrophages, corticosteroids will reduce the process of allergic contact dermatitis. In addition, it also prevents T lymphocytes, sensitive macrophages from reaching target cells. Thereby making the ability to fight cell proliferation reduces the hyperplastic tissue characteristic of psoriasis for the inflammatory process to be reduced, helping to reduce the process of allergic contact dermatitis. In addition, it prevents T lymphocytes, along with sensitive macrophages, from reaching target cells. Anti-proliferative ability reduces the hyperplastic tissue characteristic of psoriasis.

3. Indications to use Vinsolon 40mg

Vinsolon 40mg is indicated in the following cases:
Stevens - Johnson syndrome; Asthma ; Allergic rhinitis; Angioedema of the nervous system; Ulcerative colitis; Crohn's disease; Latent TB; Progressive TB; Cerebral edema due to brain tumor; Acute multiple sclerosis; Tuberculous meningitis; Graft rejection; temporal arteritis; Nodular periarteritis; Anaphylaxis; Lukemia level; Lymphoma; Breast cancer; Prostate cancer; Primary kidney failure; ... Use Vinsolon 40mg as a non-specific therapy that requires the anti-inflammatory and immunosuppressive effects of Glucocorticoid in cases as indicated.

4. Dosage and how to use Vinsolon 40mg

When using Vinsolon 40mg, it is necessary to use the correct dose, properly according to the instructions.
4.1. Dosage of Vinsolon 40mg Vinsolon 40mg should be used according to the dosage instructions from the manufacturer and doctor. Accordingly, the recommended dose is from 6-40mg/day. The maintenance dose should be lower than the dose needed to achieve the therapeutic goal. In addition, the lowest effective dose must be determined, and the dose can be adjusted in increments until efficacy or disease symptoms improve.
When high doses are used for a long time, alternate day therapy should be instituted after the course of the disease has been controlled. In this therapy, the dose should be administered only twice a day in the morning according to the natural rhythm of glucocorticoid secretion.
In addition, the use of Vinsolon 40mg dose depends on each specific disease such as:
Vinsolon 40mg dose for severe asthma: The recommended dose of Vinsolon 40mg is 60-120mg/time for 6 hours/time. When the acute asthma is over, the doctor may prescribe Vinsolon 40mg dose 32 - 48mg/day orally for 5 days. Adjust dose to lowest dose for 7 days. Dosage of Vinsolon 40mg to treat severe rheumatic diseases: According to the manufacturer's recommendations, Vinsolon 40mg dose of 0.8 mg/kg body weight/day can be used in small doses. Consolidation treatment with a single daily dose. Adjust dose to minimum dose. Dosage of Vinsolon 40mg for chronic arthritis in children: With chronic arthritis in children accompanied by life-threatening complications, it is necessary to use Vinsolon 40mg at a dose of 10-30mg/time, taking 3 times. Dosage Vinsolon 40mg nephrotic syndrome: As recommended, you can take Vinsolon 40mg at an initial dose of 0.7 - 1.6mg/kg body weight for 6 weeks. Adjust dose gradually over 6 to 8 weeks. Dosage of Vinsolon 40mg with severe allergies: Severe allergies develop in a short time, now you can use Vinsolon 40mg dose of 125mg intravenously every 6 hours. Vinsolon 40mg dose of hemolytic anemia: With immune hemolytic anemia, the dose of Vinsolon 40mg is 1000mg/day for 3 days and used for at least 6-8 weeks to achieve the effect. In addition, before blood transfusion for cases of hemolytic anemia, 1000mg can be given intravenously to prevent complications. Dosage Vinsolon 40mg Sarcoid: As recommended, dose of Vinsolon 40mg can be used 0.8mg/kg body weight/day. May be adjusted to a low dose of 8mg/day. 4.2. How to use Vinsolon 40mg The way to use Vinsolon 40mg is:
Intramuscular; Intravenous injection; Intravenous infusion – emergency. Before injecting Vinsolon 40mg, it is necessary to prepare injection solution. The nurse/nurse will draw the entire solvent into the lyophilized powder vial and shake well until the solution is completely dissolved. Then proceed with the injection as directed.

5. Contraindications Vinsolon 40mg

What is Vinsolon 40mg? Vinsolon 40mg is a drug commonly used in cases such as rheumatoid arthritis, lupus erythematosus, allergies... according to the instructions and indications of the doctor/pharmacist.
However, Vinsolon 40mg is not used for the following subjects:
Severe infections – except for subjects with septic shock, tuberculous meningitis; Hypersensitivity to components contained in Vinsolon 40mg; Skin lesions caused by viruses, fungi, tuberculosis; Use live virus vaccines; Protein allergy in cow's milk; ... The above subjects should not use Vinsolon 40mg to ensure safety.

6. Side effects of Vinsolon 40mg

When taking Vinsolon 40mg you may experience side effects including:
Increased severity of infections; Cushing's syndrome; Sodium retention, water retention; Affective disorder; Sleep disorders; Illusion; Schizophrenia; Behavioral disorders; Concerned; Subcapsular cataracts; Hypertension; Stomach ulcers; Stomach bleeding; Peripheral edema; Skin atrophy; Acne; Underdeveloped; Osteoporosis ; Muscle weakness; Wounds take a long time to heal; Decreased blood potassium; Opportunistic infections; Kaposi's sarcoma; Leukocytosis; Anaphylaxis; Hypopituitarism; Rhinitis; Conjunctivitis; Acidosis; Dyslipidemia; Dizzy; Headache; Lost memory; Corneal failure; Congestive heart failure; Arrhythmia; Diarrhea; Bone necrosis; ... In addition, you may also experience some local reactions after injecting Vinsolon 40mg including fatigue, discomfort, dizziness... Patients should notify the doctor/medical staff when experiencing the following symptoms. Vinsolon 40mg side effects.

7. Interaction Vinsolon 40mg

Using Vinsolon 40mg may cause interactions with the following drugs:
Macrolide antibacterial; Anti-tuberculosis antibiotics; Anticonvulsants Antiemetics; Antifungal drugs; protease inhibitors; Anticoagulants; Neuromuscular blocking drugs; Diabetes medication; Anticholinergic drugs; aromatase inhibitors; High-dose aspirin; Diuretics reduce blood potassium; Amphotericin B; Xanthen; beta agonists; Antihypertensive drugs; Cardiac glycosides; Mifepriston; ... It can be seen that Vinsolon 40mg interaction is quite complicated, with many drugs. Therefore, to take Vinsolon 40mg safely, inform your doctor about the medicines you are taking

8. Warnings and Precautions Vinsolon 40mg

To use Vinsolon 40mg safely, the manufacturer also gives some warnings and cautions including:
When injecting Vinsolon 40mg, it can cover up the manifestations of infection and the appearance of new infections;
Avoid contact with people with chickenpox / measles; Tuberculosis; Myasthenia; Epileptic; Cardiovascular risk; Diabetes; Do not use qus 90mg/kg/day for children who are still breastfed; Children under 3 years old; These warnings are given so that patients need to be cautious when using Vinsolon 40mg safely.

9. Pregnant women, nursing mothers, driving and operating machines use Vinsolon 40mg

Vinsolon 40mg, although not eliminated through the placenta, but there are no safety data when used in pregnant women is limited. Therefore, Vinsolon 40mg should not be used in pregnant women; Breastfeeding women should also not take Vinsolon 40mg because the drug is excreted in small amounts in breast milk. Driving and operating machinery should not take Vinsolon 40mg, because the side effects are very large.

10. Preserving Vinsolon 40mg

Vinsolon 40mg medicine stored at room temperature.
Above is the information about the drug Vinsolon 40mg. If the patient has any other concerns when using Vinsolon 40mg, please ask your doctor/pharmacist for advice.
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