Test to determine the degree of sperm DNA fragmentation

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Article written by Dr. Do Huy Duong, Vinmec High Technology Center

Sperm DNA fragmentation refers to the degree of genetic abnormality within sperm and is one of the leading causes of IVF failure, miscarriage or difficulty having children. Testing to determine the degree of sperm DNA fragmentation will help assess the likelihood of IVF success.

1. Clinical information

The genetic material integrity of the sperm is an important parameter to assess the fertility and normal development of the embryo. Sperm DNA fragmentation is the term for genetic abnormalities within sperm and is one of the leading causes of IVF failure, miscarriage or difficulty conceiving. Tests that assess sperm density, motility, and morphology cannot assess sperm quality at the molecular level.
Scientific studies show that:
Highly fragmented sperm DNA affects the development of blastocyst embryos; The higher the degree of DNA fragmentation, the higher the chances of IVF failure and miscarriage; The degree of DNA fragmentation was higher in patients with abnormal sperm count; Patients with a normal sperm count may also have a high degree of sperm fragmentation.

2. Advantages of testing

Provide information on the genetic material integrity of sperm to identify high-risk subjects; Provide information to treating physicians for the management and treatment of male infertility patients; Provides predictive value for evaluating the success of assisted reproductive methods

3. High level of sperm DNA fragmentation and pregnancy

Couples where the husband has a high level of sperm DNA fragmentation can still have a normal and healthy pregnancy, but this is less likely than a case with a low level of sperm DNA fragmentation. Embryos formed from sperm with fragmented DNA are of low quality. Fragmented sperm DNA can lead to abnormalities in the embryo's development, multiple miscarriages or medical problems in the baby.

4. Causes of sperm DNA fragmentation

Contagion Fever Smoking Addiction Alcoholism Stress Improper diet Exposure to environmental pollution Aging Age Varicose veins

5. Subjects designated for testing

Unexplained infertility Supporting embryo development Poorly developing embryos Repeated IVF failures Repeated miscarriages Varicose veins Low semen index Exposure to toxic environments Advanced age

6. Treatment for high degree of sperm DNA fragmentation

Treatment depends on the cause of the DNA fragmentation. If fragmentation is caused by free radicals, then lifestyle changes to reduce the risk of oxidative damage are essential. Other possible treatments include:
Antibiotics in case of infection Lifestyle changes: smoking, occupation Diet: clean foods especially foods containing free radical fighting factors such as vitamins C, E Sperm vein surgery Get sperm from the epididymis Using ICSI method instead of IVF IVF fertility center Vinmec is the address for infertility treatment - infertility is chosen by many couples. So far, the Center has performed fertility support for over 1000 infertile couples with a success rate of over 40%. This rate is equivalent to developed countries such as the UK, USA, Australia,...
The center gathers a team of leading experts in the field of obstetrics and gynecology nationally and internationally, trained in centers leading in the world such as in the US, Singapore, Japan, Australia and famous fertility centers in the world.
With a high level of expertise and extensive experience, Vinmec IVF Center's experts are capable of synchronously and comprehensively deploying the most advanced assisted reproductive techniques today, helping realize the dream of becoming a parent of hundreds of families across Vietnam.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

Reference source: reproductivehealthgroup.co.uk