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As an antiviral drug, Cidofovir is used for conditions caused by viral infections. However, because of the lack of experience with Cidofovir, this drug should only be used when no other treatment options are available. So what disease does Cidofovir cure, please come to the following article.
1. What disease does Cidofovir treat?
What disease does Cidofovir treat? Cidofovir is an antiretroviral drug, administered by injection in the form of a solution with a concentration of Cidofovir in each 5ml vial of 75mg/ml.
What are the effects of Cidofovir?
Cidofovir is used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS who do not have kidney failure. The drug blocks CMV replication through selective inhibition of viral DNA synthesis, reducing their rate of DNA synthesis. In addition, the drug may also be effective against viruses resistant to Aciclovir and Foscarnet. However, due to lack of experience in its use, this drug should only be used when no suitable treatment is available. For other Cytomegalovirus infections (eg, pneumonia, gastrointestinal), congenital cytomegalovirus or HIV-negative human disease, the safety and efficacy of the drug have not been established. This medicine only relieves symptoms, prevents blindness but does not cure the disease Treats complications caused by smallpox vaccine and treats smallpox (in case smallpox reappears) .
2. How is Cidofovir used?
Cidofovir is given intravenously. The medical staff will inject and monitor your use of the drug. Within 48 hours before each dose of Cidofovir you will have your kidney function checked (serum creatinine, protein in the urine). Make sure your doctor also knows if you are taking Zidovudine to treat HIV. The dose may need to be changed or discontinued on the day of the Cidofovir infusion. Cidofovir can damage the kidneys after just one or two doses. You will receive intravenous (IV) fluids and oral Probenecid while you are receiving Cidofovir (specifically, 2 g of Probenecid 3 hours before each Cidofovir infusion and 1 g of probenecid 2 hours and 8 hours after the Cidofovir infusion is stopped. , a total of 4 g Probenecid). The drug solution must be mixed in 100 ml of 0.9% sodium chloride for intravenous infusion. Be careful when mixing the drug, avoid contact with skin and mucous membranes, if contact must be washed immediately and vigorously scrubbed with plenty of soap and water. Dispose of medicine vials and drug solutions by burning. 1 to 2 hours before infusion of Cidoforvir, one liter of 0.9% sodium chloride solution should be infused. If tolerated, within 1-3 hours at the same time (or immediately after) Cidofovir infusion can add 1 liter of 0.9% sodium chloride solution. Take Probenecid with food if this medicine upsets your stomach. Continue taking Probenecid for the prescribed length of time. Skipping doses may increase the risk of complications caused by Cidofovir. Get regular medical checkups and your next Cidofovir infusion may be delayed based on the results. The drug must be given in the correct dose at the recommended rate and frequency. The specific dosage of Cidoforvir is as follows:
For adults for the first 2 weeks (consecutive) dosing induction, once weekly, 5 mg per kg body weight each time, intravenous infusion with constant speed for 1 hour. 2 weeks after completion of treatment (induction), start maintenance dose, every 2 weeks, 5 mg/kg body weight and also intravenous infusion over 1 hour at a constant rate. For patients with impaired renal function during treatment, it may be necessary to adjust the dose or stop using Cidofovir. For children and neonates, treatment data are limited. This medicine should not be given to children under 16 years of age. In people with liver failure, the safety and effectiveness of the drug has not been established.
3. What should be noted when using Cidofovir?
Before taking Cidofovir :
Tell your doctor if you are allergic to Cidofovir Have moderate to severe kidney disease Have a history of severe allergic reaction to Probenecid or Sulfa medicines . Cidofovir injection should not be given if you have used certain other medicines within the previous 7 days. Tell your doctor if you are already taking any of the following:
Blood pressure medicine; Medicines for cancer treatment; Injections to treat osteoporosis or Paget's disease of bone Medicines to prevent organ transplant rejection; Medicines to treat infections; Medicines to treat intestinal disorders; Some medicines relieve pain or treat arthritis. Tell your doctor if you have ever had:
Kidney disease; Diabetes; Pancreatic problems. Cidofovir can harm an unborn baby if the mother or father is using Cidofovir. If female, do not use Cidofovir while pregnant. Use effective birth control while using this medicine and for at least 1 month after your last dose. If you are male, use effective birth control if your partner can get pregnant. Continue using birth control for at least 3 months after the last dose.
Tell your doctor right away if pregnancy occurs while the mother or father is using Cidofovir . Women with HIV or AIDS should not breastfeed. Even if the baby is born without HIV, the virus can be passed to the baby through breast milk. Do not inject the drug directly into the eyeball (because it causes a sharp decrease in intraocular pressure and visual disturbance).
Missed dose: Call your doctor for instructions if you miss your Cidofovir injection appointment or if you miss any Probenecid dose. Overdose: Because Cidofovir is given in a medical setting, you will be closely monitored to make sure you are not receiving too much Cidofovir. Medical staff will promptly treat you if you have symptoms of an overdose. Store Cidofovir at a temperature between 15 and 30 °C. The reconstituted solution can be temporarily stored in the refrigerator at 2 to 8 degrees Celsius for up to 24 hours, do not freeze the medicine or keep for more than 24 hours after it has been reconstituted. Allow the solution to cool to room temperature before injecting.
4. Side effects of the drug Cidofovir
Get emergency medical help if you have signs of an allergic reaction: hives; shortness of breath; swelling of the throat, face, tongue, lips.
Call your doctor right away if any of the following serious side effects occur:
Change in vision, white/yellow patches on the eyes; kidney problems--swelling, rapid weight gain, little or no urination, increased thirst, loss of appetite, constipation, lower back or side pain; reduced blood cell counts--chills, fever, lightheadedness or trouble breathing, fatigue, cold hands and feet, pale skin, skin sores, easy bruising in the mouth, unusual bleeding; Pancreatitis - severe pain in the upper abdomen spreading to the back, vomiting, nausea. Some common side effects of Cidofovir such as:
Nausea, vomiting, diarrhea; Attenuate; Rash; Headache; Hair loss. Because you need to take Probenecid, you may also experience side effects of this drug such as:
Nausea, vomiting; Skin rash; Fever, chills; Headache. This is not a complete list of the possible side effects of Cidofovir and Probenecid. Tell your doctor if you are worried about any new signs of abnormality while taking this medicine.
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