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Queitoz 50 contains Quetiapina 50mg, which is available in tablet form. The drug is used in the treatment of mental illnesses such as schizophrenia, bipolar disorder... However, Queitoz 50 can cause some unwanted side effects such as dizziness, dizziness, and lightheadedness. face, drowsiness, fainting... Therefore, patients need to carefully learn information and advice from doctors before using the drug.1. Mechanism of action of the drug Queitoz 50
Queitoz 50 contains Quetiapine which belongs to the class of atypical antipsychotics. Quetiapine compounds and active human plasma metabolites and N-dealkyl derivatives Quetiapine act on a wide variety of neurotransmitter receptors in the body. Quetiapine and N-dealkyl Quetiapine has affinity for serotonin SHT2 receptors in the brain and for dopamine D1 and D2 receptors. Because of its higher selectivity for serotonin SHT2 receptors in the brain than for dopamine D2 receptors, it contributes to the clinical antipsychotic properties while having less risk of unwanted side effects on the peripheral system. Queitoz's tower.When the drug Queitoz 50 is taken into the body, it has good absorption and complete metabolism. Bioavailability of the drug is not affected by food. When entering the body, the drug is bound to plasma proteins about 83%. Quetiapine is metabolised in the liver by a CYP450 metabolite, the maximum steady-state molecular concentration of the active metabolite N-dealkyl Quetiapine at that of quetiapine about 35%. The half-life of Quetiapine with the two compounds Quetiapine and N-dealkyl Quetiapine is 7 hours and 12 hours, respectively. At the same time, this compound is excreted in feces about 20% and urine accounts for 73%.
2. Indications and contraindications for the use of Queitoz 50
Queitoz 50 is indicated in the treatment of schizophrenia or for the treatment of conditions associated with bipolar disorder. However, the drug is also contraindicated in some cases of hypersensitivity to the components of the drug.3. Dosage and how to use Queitoz 50
For the treatment of schizophrenia, the dose of Queitoz 50 should be used twice daily and can be taken with or without meals. The therapeutic dose for each day for the first four days is 50mg (01 day), 100mg (day 2), 200mg (day 3) and 300mg (day 4). However, depending on the clinical response and tolerability of the patient, it should be adjusted in the range of 150 mg to 750 mg/day.
For the treatment of manic episodes associated with bipolar disorder, Queitoz 50 should be used twice daily and may be taken with or without meals. Single therapy or supportive therapy for drugs with stabilizing effect on mental state, and the daily treatment dose for the first 4 days is 50mg (01 day), 100mg (day 2), 200mg (day 2), respectively. 3) and 300mg (day 4). The therapeutic dose can be adjusted up to 800mg/day and on day 6 but each increase should not exceed 200mg/day. Furthermore, the dose can be adjusted according to the patient's clinical response and tolerability and ranges from 200 mg to 80 mg/day. Effective therapeutic doses can range from 400 to 800 mg.
Quetiapine should be used with caution in the elderly, especially for first-time users. Because Queitoz 50 is similar to other antipsychotics. In this case, patients need to use a starting dose of 25mg/day and increase the daily dose by levels from 25mg to 50mg to achieve a therapeutic effect. However, the effective dose for the elderly is often lower than in younger patients.
The dose used above is for reference only. Therefore, depending on the specific case such as the patient's health condition as well as the disease's progression, effective indications can be given.
In case you accidentally take an overdose of Queitoz 50 compared to the prescribed amount and there are signs of unwanted side effects, it is necessary to take the patient to the nearest medical facility for emergency treatment. timely medical assistance. If the patient misses a dose, the missed dose can be used as soon as he remembers. However, if it is too close to the next dose, skip the missed dose and take the next dose as directed. Patients should also note that it is not recommended to double the dose of Queitoz 50, because it may cause drug overdose and unwanted side effects, affecting their own health.
4. Unwanted side effects and some notes when using Queitoz 50
Queitoz 50 may cause some side effects during treatment including:
Common side effects include nervous system dysfunction such as dizziness, lightheadedness, drowsiness. Uncommon or rare side effects may include syncope, rhinitis, leukopenia, tachycardia, orthostatic blood pressure, dry mouth, dyspepsia, constipation, mild weakness, peripheral edema, weight gain , increased serum transaminases, decreased neutrophils, increased blood sugar, increased polymorphonuclear leukocytes, increased gamma-GT4, serum triglycerides at any time, elevated total cholesterol, convulsions, tremor syndrome , neuroleptic malignant syndrome, erectile dysfunction, anaphylactoid reactions,... When experiencing symptoms related to side effects, discontinue use and notify a doctor for timely medical assistance. .
When using Queitoz 50, it should be noted with some subjects:
Neutropenia is rarely clinically shown with Queitoz 50. Possible risk factors for leukopenia include leukopenia. pre-existing low blood pressure, or a history of drug-induced neutropenia. However, when discontinuing the drug, patients should be monitored for signs and symptoms of infection. Hyperglycemia and pathological hyperglycemia have been reported in patients taking Queitoz 50. Therefore, people with diabetes should monitor for possible exacerbations of Queitoz 50. People with cardiovascular disease or diseases related to cardiovascular, cerebrovascular and cerebrovascular should be cautious when using Queitoz 50, because it may cause hypotension. Sudden medication can cause side effects such as nausea and vomiting, insomnia, or even a relapse of psychotic symptoms, involuntary movement disorders... Dementia has not been approved for the use of Queitoz 50 in the treatment of dementia. Because meta-analyses of antipsychotics suggest an increased risk of death associated with these subjects. In summary, the use of Queitoz 50 should be prescribed by a doctor to get the best effect as well as minimize the side effects to health.
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