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Posted by Pharmacist Nguyen Thu Giang - Clinical Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital
Combivent is an aerosol form with two main active ingredients, ipratropium bromide and salbutamol sulphate, used in the management of reversible bronchospasm due to obstructive airways disease.
Ipratropium bromide is a competitive, non-selective antagonist at respiratory muscarin receptors, relaxing bronchioles and bronchioles, with less effect on secretory glands such as salivary glands, stomach. Therefore, Ipratropium has a relaxing effect on bronchial smooth muscle, has little effect on bronchial mucus secretion, has little effect on salivary secretion, does not dilate pupils, increases intraocular pressure, and does not stimulate the nervous system. Central neutral system . Ipratropium did not alter heart rate, blood pressure, or heart rate in healthy subjects with chronic obstructive pulmonary disease (COPD) and hypertension. Salbutamol is a synthetic amino acid with sympathomimetic effects that relaxes airway smooth muscle, thereby dilating bronchi, helping to improve symptoms of dyspnea due to bronchospasm. The combination of these two drugs has a stronger bronchodilator effect than ipratropium, allowing the dose of salbutamol to be reduced, thus limiting the side effects of salbutamol.
Thuốc ombivent có tác dụng kiểm soát co thắt phế quản
What is Combivent? This is an aerosol form, so oral and infusion are contraindicated. When nebulizing, the patient will use a nebulizer or positive pressure ventilator intermittently with a mask or through an endotracheal tube to deliver the drug. It is not necessary to dilute the solution in a single dose vial for nebulization. Since single-dose vials are preservative-free, the solution should be used immediately after opening, and used only once to avoid contamination and to discard partially used, opened, or damaged vials. Combivent should not be mixed with other solutions.
When aerosolizing, be careful not to get the solution or aerosol into the eyes, especially in patients with glaucoma. Therefore, it is necessary to use a suitable, tight-fitting mask when aerosolizing.
The dose of Combivent used is quite fluctuating and needs to be prescribed by a doctor, so patients should not buy drugs without a prescription.
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Source: Vietnam National Pharmacopoeia 2015, Medicines.org.uk
