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Vadol 325 is a prescription drug that has antipyretic and analgesic effects. The drug is prepared in the form of tablets with the main ingredient in each tablet is Paracetamol 325mg. So what is Vadol 325 and how is it used?
1. What is Vadol 325?
Paracetamol is a pain reliever and fever reducer, it can replace Aspirin. However, unlike Aspirin, Paracetamol has no anti-inflammatory effects. In equal doses in grams, paracetamol has analgesic and antipyretic effects similar to aspirin.
At therapeutic doses, Paracetamol has little effect on the cardiovascular and respiratory systems, it does not change the acid-base balance, nor does it cause irritation, ulceration or stomach bleeding like Salicylates. Paracetamol has no effect on systemic cyclooxygenase, it only affects central nervous system cyclooxygenase/prostaglandin. Paracetamol does not have the same effect on platelets and bleeding time as aspirin.
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. The half-life of paracetamol is 1.25 - 3 hours, it is metabolized in the liver and eliminated by the kidneys.
Vadol 325mg is indicated to reduce fever and relieve pain for children in the following cases:
Cold, flu; Dengue ; Infection ; Viral infection; Teethe; Fever after vaccination, after surgery,... Vadol 325mg is contraindicated in the following cases:
People who are sensitive to the main active ingredient or any of its ingredients; People with liver failure; People with anemia many times; People with heart disease, lung disease, kidney or liver disease; People with G6PD deficiency. Pay attention to precautions when using Vadol 325mg in the following cases:
For patients with phenylketonuria and those who need to limit the amount of phenylalanine put into the body should avoid using Vadol 325 with drugs or food. products containing Aspartame. For some people with hypersensitivity (asthma) should avoid using Vadol 325mg with medicine or food containing sulfites. Vadol 325mg should be used with caution in patients with pre-existing anemia and impaired liver and kidney function. Drinking a lot of alcohol can increase the hepatotoxicity of Paracetamol in Vadol 325. Therefore, alcohol should be avoided or limited when using the drug. Physicians should warn patients about the signs of serious skin reactions that may occur when using Vadol 325mg, such as: Steven-Johnson syndrome (SJS); Toxic skin necrosis syndrome; Lyell's syndrome; Acute systemic pustular exanthematous syndrome.
2. Dosage and how to use Vadol 325mg
Vadol 325mg is used orally. Drink every 6 hours, if necessary.
Dosage of Vadol 325mg should be according to the doctor's instructions, the reference dose is as follows:
Children from 6 to 12 years old: Use a dose of 1 tablet / time. Adults and children over 12 years old: Use a dose of 1.5 tablets / time. Note on the use of Vadol 325mg:
Maximum dose in 24 hours for children: Do not take more than 5 times a day. Do not prolong self-administration of Vadol 325 without consulting a doctor when: New symptoms appear. High fever > 39.5oC and persists for more than 3 days or recurs. Pain is severe and lasts more than 5 days. Overdose of Vadol 325mg usually occurs due to a single toxic dose or repeated large doses of Paracetamol from 7.5 to 10g per day, continuously for 1-2 days, or by taking the drug for many days. Dose-dependent hepatic necrosis is the most serious acute toxic effect that occurs from overdose and can be fatal.
Manifestations of drug overdose Vadol 325mg include:
Nausea, vomiting; Stomachache ; Blue-violet color in skin, mucous membranes and nails. Manifestations of severe Paracetamol poisoning include:
Initially only mild irritation, agitation and delirium. Next is central nervous system depression with manifestations such as: stupor, fatigue, hypothermia, rapid/shallow breathing, rapid, weak, irregular pulse, circulatory failure and low blood pressure. Treatment: Early diagnosis of Vadol 325mg overdose is very important in treatment. In severe paracetamol poisoning, active supportive treatment is required. Gastric lavage should be performed in all cases, preferably within 4 hours of taking the drug.
Paracetamol detoxification therapy is the use of Sulfhydryl compounds. N - acetylcysteine is effective when used orally or intravenously. In addition, your doctor may also use methionine, activated charcoal, and/or salt bleach.
3. Side effects of the drug Vadol 325mg
During the use of Vadol 325mg, you may encounter side effects of the drug.
Rare side effects of Vadol 325mg include:
Skin rash; Nausea, vomiting; Kidney disease, kidney toxicity occurs with long-term drug abuse; Decrease in neutrophils; Decrease in total platelet count; Anemia. Rare side effects of Vadol 325mg include:
Hypersensitivity reactions. During the use of Vadol 325mg, if you experience any unusual symptoms, immediately notify your doctor or go to the nearest medical facility for timely treatment.
4. Interaction of Vadol 325mg with other drugs
Long-term intake of high doses of Vadol 325mg will slightly increase the anticoagulant effect of Coumarin and Indandion derivatives. Attention should be paid to the risk of severe hypothermia when phenothiazines and antipyretic therapy are used concomitantly. Anticonvulsants (such as Phenytoin, Carbamazepine, Barbiturates), Isoniazid and anti-tuberculosis drugs can increase the toxicity of paracetamol in Vadol 325mg to the liver. Excessive and long-term alcohol consumption can increase the risk of Vadol 325mg causing liver toxicity. The article has provided information on what Vadol 325mg is, dosage and precautions for use. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Vadol 325mg exactly as directed by your doctor. Store Vadol 325mg in a dry place, the temperature does not exceed 30 degrees Celsius and out of the reach of children.
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