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Celecoxib is a very commonly used NSAID. This active ingredient is present in the drug Celosti 200. Similar to other NSAIDs, the use of Celosti 200 must be in accordance with the indications and measures to prevent side effects from occurring.
1. What is Celosti 200?
Celosti 200 has the active ingredient Celecoxib 200mg as the main active ingredient. This is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic, antipyretic effects. Celosti 200 is a hard capsule, white to ivory, with a pattern on the capsule. The drug is packaged in a box of 2 blisters x 10 tablets. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which has anti-inflammatory, analgesic, and antipyretic effects by inhibiting prostaglandin synthesis, mainly through COX-2 inhibition. reduces the formation of prostaglandin precursors. Because it does not inhibit COX-1, Celecoxib poses little risk of adverse effects on the gastric mucosa and platelets.
2. The effect of the drug Celosti 200
Celosti 200 is indicated for use in the following cases:
Effects of Celosti 200 for symptomatic treatment of degenerative joint disease (OA), rheumatoid arthritis (RA); Celosti 200 is an adjuvant treatment for the relief of signs and symptoms of juvenile idiopathic arthritis (JIA) in patients 2 years of age and older who weigh at least 10 kg. Celosti 200 is used for the palliative treatment of the signs and symptoms of ankylosing spondylitis. Treatment of primary dysmenorrhea.
3. Dosage of the drug Celosti 200
Celosti 200 is taken orally, taken with or without food, for patients who have difficulty swallowing Celosti 200 capsules, the amount of medicine in the tablet can be added to smoothies, porridge, yogurt or crushed bananas to drink. Because Celosti 200 has an increased cardiovascular risk with dose and duration, the lowest dose of Celosti 200 should be used for the shortest time. Dosage of the drug Celosti 200 for adults:
Symptomatic treatment of osteoarthritis: a dose of 200mg for a single dose or 100mg for 2 times a day; Symptomatic treatment of rheumatoid arthritis: dose of 100mg or 200mg, twice a day; Ankylosing spondylitis: 200mg as a single dose or 100mg, twice a day, some patients may be better off with a total dose of 400mg Celosti 200 per day; Acute pain control: Initial dose of Celosti 200 is 400mg, an additional 200mg dose is given on the first day if necessary, 200mg twice daily is recommended for subsequent days as needed; Treatment of primary dysmenorrhea: The starting dose of Celosti 200 is 400mg, an additional dose of 200mg is used on the first day if necessary, the following days it is recommended to use 200mg twice a day as needed; Usual dose of Celosti 200 in adults: 400mg/time, followed by 200mg if needed on the first day, for continued pain relief, 200mg twice daily if needed; For patients with poor CYP2C9 metabolisers: caution should be exercised when administering Celosti 200, starting with the lowest recommended dose of 1⁄2 of the recommended dose. Combined use of Celosti 200 with Fluconazole: Celosti 200 should be used with 1⁄2 of the recommended dose. Dosage of Celosti 200 for children 2 years and older in juvenile idiopathic arthritis: dose according to weight as follows: from 10-25kg: 50mg, 2 times/day; over 25kg, use 100mg dose, 2 times/day. People over 65 years old do not need to adjust the dose of Celosti 200, for elderly people under 50kg, the lowest recommended dose of Celosti 200 must be used when starting treatment. Patients with mild liver impairment do not need to adjust the dose of Celosti 200, use 1⁄2 doses of Celosti 200 for patients with moderate hepatic impairment and there has been no study in patients with severe liver impairment. Patients with renal impairment: No dose adjustment of Celosti 200 is required in patients with mild and moderate renal impairment, but there have been no studies in patients with severe renal impairment.
4. Expression of overdose Celosti 200
Overdose of non-steroidal anti-inflammatory drugs such as Celosti 200 can cause lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Manifestations of overdose with Celosti 200 occur rarely, such as hypertension, acute renal failure, respiratory depression, coma. Anaphylactoid reactions have been reported with therapeutic doses of Celosti 200 and may occur with overdose.
Treatment of drug overdose Celosti 200: Symptomatic and supportive treatment, no specific antidote. During the first 4 hours after an overdose of Celosti 200, emetic therapy and/or activated charcoal and/or osmotic bleach may be useful in patients who are already symptomatic or have taken large amounts of Celosti 200. too big.
5. Side effects of Celosti 200
When using Celosti 200, patients may experience some unwanted effects as follows:
Abdominal pain, loose diarrhea, indigestion with bloating and nausea; Myocardial infarction, angina; Hypertension; Shortness of breath ; Insomnia, dizziness, headache; Skin rash; Back pain, peripheral edema; Ear infection or fungal infection. Some less common side effects of Celosti 200: Helicobacter pylori infection, Herpes zoster; gingivitis, inflammation of the inner ear; sleep disorders; Deep vein thrombosis ;
6. Contraindications of Celosti 200
Celosti 200 is contraindicated for use in the following cases:
History of hypersensitivity to Celecoxib or any component of Celosti 200. History of hypersensitivity to sufonamide. History of asthma, urticaria, other allergic-type reactions after taking Aspirin or other non-steroidal anti-inflammatory drugs; Pain relief during artificial coronary artery bypass grafting (CABG).
7. Note when using Celosti 200
7.1. Cardiovascular thromboembolism risk Non-steroidal anti-inflammatory drugs (NSAIDs), other than aspirin, given by the systemic route, may increase the risk of cardiovascular thrombotic events such as myocardial infarction, stroke, or death. The risk usually appears as early as the first few weeks of taking Celosti 200 and can increase over time and is observed mainly at high doses. To minimize the risk of adverse events, Celosti 200 should be used at the lowest effective dose for the shortest time.
7.2. Hypertension Celecoxib active ingredient of Celosti 200 may lead to hypertensive crisis or worsen already existing hypertension, therefore blood pressure should be closely monitored at the start of treatment with Celosti 200 and throughout. treatment time.
7.3. Fluid retention, edema Patients using Celosti 200 should be closely monitored if they have congestive heart failure or hypertension. Celosti 200 should be used with caution in patients with compromised cardiac function, edema, or other conditions that may be aggravated by fluid retention. Effects on the gastrointestinal tract: Celosti 200 is also an NSAID, so it can cause perforation, ulceration or bleeding in the upper and lower gastrointestinal tract, especially dangerous when the patient is elderly, has cardiovascular disease or is taking Aspirin. , Corticosteroids... Effects on the kidneys: Celecoxib can cause nephrotoxicity, caution should be exercised when starting treatment with Celosti 200 for dehydrated patients. Close monitoring of renal function is required in patients with advanced renal disease while taking Celosti 200. Concomitant use of Celosti 200 with oral anticoagulants may increase the risk of bleeding, and should therefore be used with special caution. Inhibition of CYP2D6: It is necessary to reduce the dose of drugs metabolized by CYP2D6 when co-administered with Celosti 200. Celosti 200 can cause uterine muscle impotence and premature closure of the aortic duct, so the use of celecoxib should be avoided during the third trimester of pregnancy. Very little celecoxib is excreted in milk. Because celecoxib can have serious adverse effects in nursing infants, consideration should be given to discontinuing breastfeeding while taking Celosti 200 .
8. Celosti 200 . Drug Interactions
Bleeding complications associated with increased prothrombin time have occurred in some elderly patients when Celosti 200 is co-administered with warfarin. Celecoxib may decrease renal clearance of lithium, thereby increasing lithium levels again. Concomitant administration of Celosti 200 and aspirin may lead to an increased incidence of peptic ulcers. Celosti 200 may reduce the antihypertensive effect of ACE inhibitors. Celosti 200 has a high risk of nephrotoxicity when used with Cyclosporin. Concomitant administration of Celosti 200 with the antifungal fluconazole/ketoconazole may lead to increased plasma concentrations of Celecoxib. Dextromethorphan and metoprolol can increase blood levels when taken with Celosti 200 . Celosti 200 may reduce the diuretic effect of furosemide loop diuretics and thiazide diuretics.
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