Nabumetone: Uses, indications and precautions when using

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Nabumetone is an anti-inflammatory and pain reliever that belongs to the group of NSAIDs. The drug works to reduce pain, reduce swelling and stiffness in the setting of arthritis. So what is nabumetone and how should it be used to get the most out of it?

1. What are the effects of nabumetone?

What is nabumetone? This is a drug that works to reduce pain, reduce swelling and stiffness in the setting of arthritis. Nabumetone is a member of the group of non-steroidal anti-inflammatory drugs (NSAIDs). However, the drug nabumetone should only be used in acute arthritis, limited long-term use.
Therefore, if people with chronic arthritis should discuss with their doctor about non-pharmacological treatments or using other pain relievers.

2.How to use nabumetone

Before starting to use nabumetone, the patient should consult the Medication Guide provided by the pharmacist. If you have any questions or concerns, talk to your doctor or pharmacist.
Nabumetone is used orally according to the instructions of the doctor, the patient should take it once or twice daily with a full glass of water (about 240ml of water). Limit lying down for at least 10 minutes after taking the medicine. To limit stomach upset side effects, take the medicine after meals or with an antacid.

The dose of nabumetone depends on the severity of the disease and the patient's response to treatment. To limit side effects, use nabumetone at the lowest effective dose for the shortest time possible. Do not increase the dose or take it longer than directed by your doctor. For chronic arthritis, medication should be taken as prescribed by the treating doctor.
In some cases (such as arthritis), it can take up to 2 weeks after starting regular use for nabumetone to be most effective.
If the patient only takes medication for temporary joint pain or swelling (not on a regular schedule) it may not be effective. Because you need to know that pain relievers only work at the first signs of pain. If the pain has progressed, the medication may not work.

3. Nabumetone side effects

Common side effects when using nabumetone are as follows:
Abdominal discomfort; Nausea, vomiting; Constipation or diarrhea; Flatulence, indigestion; Dizzy; Drowsiness or headache. If these effects persist or get worse, tell your doctor or pharmacist right away. The doctor has evaluated before using nabumetone about the risks and benefits for the patient.

The drug nabumetone can increase blood pressure. Therefore, patients need to have their blood pressure checked regularly and tell their doctor if the results are abnormally high.
In addition, some other side effects may appear but are not serious such as:
Changes in hearing (such as tinnitus); Mental and mood changes; Difficulty swallowing or painful swallowing; Signs of heart failure (such as swollen ankles and feet, fatigue, unusual or sudden weight gain). In particular, call 911 right away if you have any of the following rare but very serious side effects:
Signs of kidney disease (such as change in the amount of urine); Unexplained stiff neck. Nabumetone rarely causes serious (possibly fatal) liver effects. If the patient notices the following signs of very serious liver damage, nabumetone should be discontinued and a doctor consulted:
Dark urine; Persistent nausea, vomiting; Stomachache; Yellow eyes or skin. Very serious allergic reactions have rarely occurred when nabumetone is taken. However, if there are any symptoms of a serious allergic condition, including: generalized rash, itching, swelling of the face, tongue, throat, dizziness, difficulty breathing... the patient should contact doctor for treatment.

4.Measures to prevent side effects when using nabumetone

Before treating a disease with nabumetone, the doctor should know in advance the history of allergy to the drug or to aspirin, other NSAIDs (ibuprofen, naproxen, celecoxib) and any other allergy history.
Patient's medical history is important before taking nabumetone, especially:
Asthma or history of shortness of breath after taking aspirin or other NSAIDs); Bleeding or clotting disorders; Nasal polyps; Heart disease such as myocardial infarction; Hypertension; Liver failure; Stroke; Gastrointestinal or gastrointestinal disease (eg, bleeding, ulceration, reflux). Kidney problems can occur after using NSAIDs, including nabumetone. In particular, the risk is increased if the patient is dehydrated, has heart failure or has kidney disease in the past, is elderly or when using certain products that cause drug interactions with nabumetone.
The patient should drink enough water as directed by the doctor to avoid dehydration and immediately notify the doctor if there is an abnormal change in the amount of urine.
Nabumetone may cause dizziness or drowsiness. Therefore, products that can cause similar conditions should be avoided with this drug, including alcohol or marijuana. Do not drive or perform tasks requiring alertness if the patient is dizzy. In addition, nabumetone can also cause stomach bleeding as a side effect. Daily alcohol use and smoking, especially when used with nabumetone, can increase the risk of stomach bleeding.
In addition, nabumetone makes the skin more sensitive to the sun, so patients need to limit time in the sun. Use sunscreen and wear long-sleeved clothes when going outside.
Older adults may have an increased risk of gastrointestinal bleeding, kidney problems, heart attack and stroke when using nabumetone.
Women of childbearing age should talk to their doctor about the benefits and risks (such as miscarriage, difficulty getting pregnant) when using nabumetone. Tell your doctor if you are pregnant or plan to become pregnant. During pregnancy, nabumetone should only be used when absolutely necessary, not recommended in the first and third trimesters of pregnancy because of its harmful effects on the fetus and the process of normal labor and delivery.

5.Nabumetone drug interactions

Drug interactions that change drug action or increase the risk of serious side effects. Therefore, it is necessary to share with the doctor about all the medications the patient is taking. Do not arbitrarily use, stop taking or change the dose of any medicine, including nabumetone without your doctor's consent.
Products that may interact with nabumetone include:
Aliskiren; ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan); Cidofovir; Corticosteroids; Lithium; Methotrexate; Diuretics such as furosemide. Medicines that can cause stomach bleeding when used with nabumetone increase the risk of bleeding. Examples are antiplatelet drugs, anticoagulants such as dabigatran, enoxaparin, warfarin.
Check all pain relievers and antipyretics you are taking (aspirin, celecoxib, ibuprofen, ketorolac) because these are similar to nabumetone and increase the risk of side effects when taken together. However, patients taking low-dose aspirin to prevent a heart attack or stroke should continue their current aspirin dose unless otherwise directed by their doctor.
Symptoms of overdose may include: severe stomach pain, vomiting of colorants like coffee grounds, extreme drowsiness, loss of consciousness, slow or shallow breathing... call immediately for first aid.
Doctor-approved non-drug arthritis treatments (such as weight loss, strengthening and conditioning exercises) that improve your flexibility, range of motion, and joint function patient.
Store nabumetone at room temperature, away from direct sunlight and high humidity. Do not leave the medicine in the bathroom and keep it out of reach of children. Nabumetone is a drug that is used to relieve pain, reduce swelling and stiffness in arthritis. However, improper use can cause some unwanted side effects. Therefore, when there is a history of musculoskeletal disease. Patients need to go to medical facilities to examine, do general tests, when indicated to use the drug, the doctor will advise how to use and the most appropriate dosage to ensure the health of the patient. sick.

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Reference source: webmd.com