Metabolic changes in patients with latent autoimmune diabetes mellitus LADA

This is an automatically translated article.

Diabetes is one of the diseases that can cause many dangerous complications. Some people when they are old enough to have the disease without having type 2 diabetes, or type 1, it is a manifestation of latent autoimmune diabetes LADA

1. Progression of latent autoimmune diabetes LADA

A person with LADA latent autoimmune diabetes may not know they have the disease even though they may have symptoms characteristic of type 2 diabetes. According to research, about 10% of people are diagnosed as having type 2 diabetes. have type 2 diabetes, but they actually have LADA latent autoimmune diabetes. These patients will need insulin to stabilize blood sugar because the immune system will stop producing insulin, disrupting sugar metabolism of beta cells.
Early diagnosis of latent autoimmune diabetes LADA helps patients stabilize blood sugar and limit health risks due to diabetes consequences.

2. Metabolic changes in patients with latent autoimmune diabetes

The features of LADA latent autoimmune diabetes are that the beta-cell function of the endocrine pancreas is still quite good at the time of diagnosis and insulin resistance, so it is easy to misdiagnose with type 2 diabetes.

Therefore, additional testing for anti-GAD and ICA antibodies is needed to confirm.
In patients with latent LADA autoimmune diabetes who may have decreased insulin sensitivity, individuals with the greatest insulin resistance will have the fastest progression to true diabetes.
Patients with LADA latent autoimmune diabetes have a lower rate of metabolic syndrome than type 2 diabetes. But the prevalence of metabolic syndrome remains high in LADA latent autoimmune diabetes, depending on the criteria. diagnosis of latent autoimmune diabetes mellitus LADA. Therefore, it is not advisable to distinguish type 2 diabetes from latent autoimmune diabetes LADA on the basis of metabolic syndrome differences.

Early treatment with insulin in patients with latent autoimmune diabetes mellitus LADA with high anti-GAD antibodies, reduces the rate of inability to secrete insulin, as determined by Peptide C.
Metformin is useful in metabolic control in type 2 diabetes, so it may be beneficial to combine metformin and insulin in the treatment of latent autoimmune diabetes with LADA.

At Vinmec International General Hospital, we always deploy a screening package for diabetes and dyslipidemia to help detect pre-diabetes early, accurately classify diabetes type, develop a nutritional regimen, according to the guidelines. Monitor to reduce the risk and complications caused by diabetes.
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