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Article by Pharmacist, Master Pham Thi Kim Dung - Pharmacist Mixing drugs - Faculty of Pharmacy - Vinmec Times City International General Hospital
Lenvima (Lenvatinib) belongs to the group of anti-cancer drugs, has anti-angiogenic properties that nourish cancer cells and directly inhibit tumor growth. This medicinal product was first approved by the US Food and Drug Administration (FDA) in 2015 with two strengths of 4mg and 10mg. Currently, the drug is available at Vinmec Times City with the concentration of lenvima 4mg.
1. Indications of using Lenvima in what case?
Lenvima is approved by the Vietnam Drug Administration for the treatment of cancer:
Thyroid carcinoma: Monotherapy for adult patients with differentiated thyroid carcinoma (DCT) (cell) papillary/follicular cells/Hürthle cells) locally advanced or metastatic, resistant to radioactive iodine (RAI). Hepatocellular carcinoma: Monotherapy for adult patients with advanced or inoperable hepatocellular carcinoma (HCC) who have not previously received systemic therapy.
2. How to use Lenvima?
Treatment with Lenvima should be initiated and supervised by an Oncologist. For each indication, the drug dosage is as follows:
2.1. Differentiated thyroid carcinoma (DCT)
Recommended dose: 24mg once a day.
2.2. Hepatocellular carcinoma (HCC)
Recommended dose: 8mg once a day for patients weighing <60kg and 12mg once a day for patients weighing ≥60kg. Adjust daily dose based on observed toxicity and not on weight change during treatment. Dosage can be adjusted down if the patient experiences side effects.
Lenvima should be taken at the same time each day, with or without food. The patient should swallow the tablet whole with water. If it is necessary to dissolve the capsule, soak the intact capsule in a small glass containing a tablespoon of water or apple juice for at least 10 minutes then stir for at least 3 minutes to dissolve the capsule shell.
Besides, the patient should pay attention not to open the capsule to avoid repeated contact with the drug ingredient in the tablet. After drinking this suspension, the patient should rinse the glass with water or apple juice and drink all of the liquid.
3. Unwanted effects when taking Lenvima
The most common adverse reactions with drug use include hypertension, proteinuria, hepatotoxicity, renal failure, nausea, vomiting, diarrhea, constipation, abdominal pain, decreased appetite, weight loss, and fatigue. fatigue, decreased platelet count leading to easy nosebleeds, bleeding gums, easy bruising...), decreased white blood cell count, hair loss, muscle and joint pain, hoarseness, dry mouth, mouth ulcers ..
Patients need to notify their doctor if they experience any unusual symptoms while taking the drug.
Tác dụng không mong muốn khi dùng thuốc Lenvima gồm buồn nôn
4. Notes when using Lenvima
If the patient misses a dose and cannot take it within 12 hours, skip the missed dose and take the next dose at the usual time of the day. In addition, patients should consult their doctor or pharmacist when using Lenvima with any other drugs. Lenvima (Lenvatinib) belongs to the group of anti-cancer drugs, has anti-angiogenic properties that nourish cancer cells and directly inhibit tumor growth.
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