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Posted by Pharmacist Nguyen Thu Giang - Clinical Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital
Carmanus drug with the main active ingredient is Carduus marianus is widely used for the purpose of liver tonic. To use the drug effectively, the patient needs to take the drug according to the prescription or as directed by the doctor or pharmacist.
1. Ingredients and active ingredients of Carmanus
Cardus marianus extract is extracted from the plant Cardus marianus, the main active ingredient is silymarin marianum - a mixture of flavonoids including silydianin, silychristine and silybin, of which silybin has the strongest biological effect. Cardus marianus tree has the Vietnamese name of milk thistle.Milk thistle (Silybum marianum) also known as holy thistle, thistle, chrysanthemum is a species of flowering plant in the family Asteraceae, which grows wild in the Mediterranean region. Since the medical discovery of the medicinal substance silymarin in milk thistle, this plant has been cultivated all over the world. Silybum marianum extracted from milk thistle is a popular functional food widely used in the United States and Europe. Cardus marianus extract has the effect of inhibiting liver cell damage: stabilizing the membrane of liver cells and microsomes by inhibiting lipid peroxidation in the membrane, increasing metabolism in the liver, increasing protein synthesis in cells. liver by stimulating the ribosomal RNA polymerase activity. In addition, they also increase the detoxification effect in the liver, reduce the oxidation of glutathione in the mitochondria and liver caused by iron overload, have the effect of chelating iron, reducing the activity of biological agents. Tumors, hepatotoxic drugs, stabilize mast cell membranes against radiation-induced inhibition of DNA and RNA synthesis in the spleen and liver. In addition, the plant Cardus marianus has some estrogen-like effects, may stimulate breast milk production in lactating women, and has beneficial effects on men with prostate cancer. prostate .
Trong quá trình sử dụng thuốc Carmanus, người bệnh có thể bị khó chịu ở dạ dày
2. Indications for the use of the drug Carmanus
Currently, the drug is indicated for use in the following cases: Fatty liver, protecting liver function in people with chronic liver disease, liver failure in alcoholics, protecting the liver when using toxic drugs. properties in the liver, supporting the treatment of acute and chronic hepatitis, cirrhosis. However, this drug should not be used in cases of advanced gastric ulcer, arterial bleeding, severe hypotension.
Besides, when taking this drug should not be used simultaneously with oral contraceptives because Silymarin reduces the effectiveness of oral contraceptives.
During the use of the drug, patients may experience some unwanted effects such as diarrhea, upset stomach, dry skin, jaundice, increased skin pigmentation. In addition, the drug also reduces glucose tolerance, increased sebaceous gland secretion, hyperuricemia, headache, blurred vision, hypotension, dizziness, heart palpitations. Therefore, drugs should not be abused without the guidance of medical personnel.
In order for the drug to work best, users need to use the drug according to the instructions of the doctor or pharmacist, should not abuse it, which can affect health.
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TLTK: SPC
