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Article by Pharmacist, Master Pham Thi Kim Dung - Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital
Kryxana® is used to treat a type of advanced or metastatic breast cancer in premenopausal or postmenopausal women. During use, the drug can cause some unwanted side effects. Therefore, the patient should strictly follow the instructions when taking the drug.
1. What is Kryxana®? The active ingredient of Kryxana ® is ribociclib. It is used to treat advanced or metastatic breast cancer in premenopausal or postmenopausal women. Your doctor will need to examine and evaluate many factors before advising you to use Kryxanar ® for treatment. You may need to take it in combination with other drugs for optimal treatment.
2. Uses of Kryxana® Kryxana ® selectively inhibits cyclin-dependent kinases 4 and 6, affecting cell cycle activity and reducing breast cancer cell line proliferation. In addition, the drug can help reduce the size of the tumor.
Bạn chỉ dùng Kryxana® khi được kê đơn và theo dõi bởi bác sĩ chuyên khoa
3. Usage and Dosage of Kryxana® You should only take Kryxana ® when prescribed and under the supervision of a specialist. Accordingly, you should take the drug in the morning, absorption and effects of the drug do not depend on meals, you can take it when hungry (before meals) or after meals.
You should take the medicine at the same time of day to increase adherence to treatment, avoid forgetting the medicine. In case you miss a dose or vomit after taking it, you should not make up for it, but take the next dose as scheduled. Do not take a double dose at a time.
To ensure effective treatment, you need to swallow the tablet whole, do not break or crush the tablet. Do not take tablets that have been broken or crushed. The usual dose of Kryxana ® is 600mg once daily for 21 days with a 7-day break to complete a 28-day cycle.
Medicines may require several cycles to improve the condition. You will need regular follow-up visits or appointments with your doctor for evaluation and follow-up. Your doctor will advise you on how long to take the medicine. You should not stop taking the medicine on your own even if you feel better or your symptoms improve.
In case your liver and kidney function is impaired, your doctor may consider reducing your dose. You need to use the correct dose of medication prescribed. Do not increase or decrease your dose without consulting your doctor.
4. Possible side effects when taking Kryxana® While taking this medicine, you may feel tired, nausea, constipation, diarrhea, headache, cough, rash, hair loss. .. Not all patients experience side effects and not all of these side effects will happen to you.
If you experience any unusual symptoms or discomfort, you should talk to your doctor during your scheduled or routine visits for evaluation and follow-up. Maybe, your doctor will prescribe you a few more medications to reduce some of the side effects.
When experiencing abnormal symptoms of severe or prolonged severity including cough, chest pain, shortness of breath, unexplained fainting... you need to immediately notify a doctor or go to a medical facility for examination. and timely treatment.
Kryxana ® induces vomiting with a high incidence and moderate to severe vomiting. Therefore, your doctor may prescribe antiemetics to prevent vomiting while taking them.
The drug can have serious side effects on the skin, you need to tell your doctor right away if you develop a severe or peeling skin rash or are accompanied by a fever > 38oC. In addition, the drug can prolong the QT interval on the electrocardiogram, cause cardiac arrhythmias or cause syncope. Your doctor will check your electrocardiogram before you start taking the medicine. During treatment, your doctor will continue to monitor your electrocardiogram during a number of routine visits. If you feel your heart beat slower than normal or faint for no apparent reason, you should immediately seek medical attention for evaluation and monitoring.
The drug may have an effect on the lungs, liver and hematopoietic system. Your doctor will check your blood count and liver function before using this medicine and periodically monitor it during treatment.
Thuốc Kryxana® gây nôn với tỷ lệ gặp cao và tình trạng nôn trung bình đến nặng
5. Precautions when using Kryxana® You need to talk to your doctor about your medical history, including chronic comorbidities, especially electrolyte disturbances, heart problems. such as unstable angina, history of new myocardial infarction, prolongation of the QT interval on known electrocardiogram...
Kryxana ® may interact with many drugs, including over-the-counter drugs and functional foods . Drug interactions may affect or increase the toxicity of Kryxana ® . Therefore, you need to discuss with your doctor or pharmacist all the medicines you are taking or need to add for any reason during your treatment.
You need to take the medicine exactly as prescribed and have regular check-ups to ensure the effectiveness of the treatment as well as to evaluate and monitor the side effects of the drug. If you're not postmenopausal, you'll need to use birth control for the entire time you're taking the pill and for at least 3 weeks after your last dose. Do not breast-feed while taking this medicine and for up to 3 weeks after the last dose.
Medicines should be stored in a dry place and out of reach of children.
Kryxana® is used to treat a type of advanced or metastatic breast cancer in premenopausal or postmenopausal women. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by the doctor or pharmacist.
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