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The article was professionally consulted by a doctor of Biochemistry - Laboratory Department - Vinmec Ha Long International HospitalThe highly sensitive C-reactive protein (hs-CRP) test is an early detection method for people at risk for cardiovascular disease. In particular, the severity of acute myocardial infarction is strongly correlated with hsCRP levels.
1. Learn about hs-CRP
1.1 What is hs-CRP test? CRP is a C-reactive protein, belonging to the Pentraxin group, produced by the liver and secreted into the blood. At the peak of the acute inflammatory response phase, CRP synthesis may account for up to 20% of the liver's protein synthesis capacity. Normally, the level of CRP synthesized per day is around 1 - 10mg. However, during the acute inflammatory phase, CRP can be synthesized above 1g/day. Elevated CRP levels increase the risk of cardiovascular disease.
In healthy people, the mean CRP concentration in the blood does not exceed 1mg/L. Elevated levels of CRP reflect inflammatory tissue mass or activity due to underlying diseases such as acute myocardial infarction, malignancies, or diseases such as rheumatoid arthritis.
The hs-CRP test is a test used to measure low levels of C-reactive protein in the blood to assess future risk of cardiovascular disease. The benefits of measuring hs-CRP levels are:
The stability of the hs-CRP index during the day; Relatively long half-life (about 19 hours); hs-CRP can be quantitatively assessed by fresh or frozen plasma; High sensitivity; Affordability. Currently, the hs-CRP test is often performed in combination with other tests such as cholesterol, HDL-c, LDL-c, triglycerides,... to predict the risk of cardiovascular diseases.
Xét nghiệm hs-CRP giúp chẩn đoán bệnh lý tim mạch
1.2 What does the hs-CRP value say? People with high hs-CRP values have a higher risk of cardiovascular disease than people with lower hs-CRP values. The risk of disease depends on the specific hs-CRP index as follows:
Low risk: < 1.0 mg/L; Moderate risk: 1.0 - 3.0 mg/L; High risk: > 3.0 mg/L. However, these values represent only a fraction of the overall conclusion of the cardiovascular pathology assessment. Indicators of cholesterol, triglycerides, LDL-c, and glucose will reinforce the diagnosis. In addition, a number of other factors that increase the risk of cardiovascular disease should also be considered, including: Smoking, diabetes, high blood pressure, ...
2. What is the hsCRP level in patients with acute myocardial infarction?
2.1 Testing hs-CRP in patients with acute myocardial infarction Many studies have concluded that inflammation affects the appearance and progression of atherosclerotic plaques, and is related to atherosclerotic disease. arteries and acute myocardial infarction. And C-reactive protein (CRP) has diagnostic value in cardiovascular diseases, including acute myocardial infarction.
Xét nghiệm hs-CRP chẩn đoán nhồi máu cơ tim cấp
2.2 The concentration of hsCRP in patients with acute myocardial infarction Data collection technique
Each patient with acute myocardial infarction is examined for hs-CRP concentration 3 times (2ml of blood clot):
1st time: As soon as hospitalize; 2nd time: Performed at 48 hours after acute myocardial infarction; Third time: Performed on the 7th day after acute myocardial infarction In addition, the patient is also assigned to perform tests such as: Troponin I, CK-MB, chest X-ray, electrocardiogram, ultrasonography. echocardiogram,...
Data processing and research materials
The values of hs-CRP in each group will be calculated as the average. The concentration of hs-CRP is conventionally expressed in units of mg/L.
Results of hs-CRP concentration in patients with acute myocardial infarction
Survey of hs-CRP concentration for the first time: 8.96 ± 8.31; The second survey of hs-CRP concentration: 33.12 ± 23.26; Survey of hs-CRP concentration for the third time: 17.56 ± 14.27. The concentration of hs-CRP in patients with acute myocardial infarction tends to increase gradually and peak at 48 hours after the onset of the disease.
Based on hs-CRP test, it is possible to predict the risk of cardiovascular diseases in healthy people. However, in addition to this test method, it is also necessary to carry out a series of other measures to get the most accurate diagnosis results and have a more timely and effective treatment plan.
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