How is biliary atresia affected?

This is an automatically translated article.


The article is professionally consulted by Specialist Doctor I Dong Xuan Ha - Department of Medical Examination and Internal Medicine - Vinmec Ha Long International General Hospital.
The condition of biliary stricture can cause many serious consequences for patients such as cholangitis, scarring on the liver, cirrhosis, liver failure, hypertension,...

1. What is biliary atresia?

Bile is a digestive fluid produced by the liver that travels through the bile ducts down to the small intestine, helping to digest fats. Biliary atresia includes congenital biliary atresia (affecting only neonates) and biliary atresia from other causes. This is a condition in which the bile ducts are blocked, preventing bile from the liver from entering the duodenum (small intestine).
The classification of biliary atresia is based on the location of the stenosis of the extrahepatic biliary system. Includes:
Type I: Common bile duct stenosis; Type II: Narrowing up to the common hepatic duct; Type III: Narrowing up to the hilum of the liver (the most common type).

Hẹp đường mật khiến mật không xuống được tá tràng
Hẹp đường mật khiến mật không xuống được tá tràng

2. Complications of biliary stricture

The bile duct is narrowed, causing bile not to pass from the liver to the small intestine, which will back up into the liver, causing cholestasis. Cholestasis causes destruction of hepatocytes, replacing hepatocytes with scar tissue, leading to jaundice and secondary biliary cirrhosis. Scarring in the liver impedes blood flow through the liver, causing liver cell death and further scarring. As a result, the patient's liver function deteriorated rapidly.
Cholestasis prevents the liver from excreting bilirubin through the bile ducts, accumulates bilirubin in the blood, causing abnormal manifestations such as: Easy skin rashes, nosebleeds, pale stools, dark urine, underdevelopment (due to poor absorption of nutrients), pain in the right side of the abdomen (biliary colic), abdominal distention,...
Common complications of the disease are cholangitis, cholelithiasis , cirrhosis, hypertension,... If not treated promptly and effectively, congenital biliary atresia can lead to liver failure. At that time, liver function can be completely destroyed, the risk of death from liver failure is very high.
Occasionally, the patient may have symptoms of sepsis or hypotension due to ascending cholangitis. In addition, patients with biliary strictures also have dilated veins in the stomach and esophagus. Increased pressure in the veins of the stomach and esophagus can cause blood to leak, causing internal bleeding or vomiting blood. In many cases, patients with biliary atresia require hemostasis by intravenous sclerotherapy.
Biliary atresia is a dangerous disease that can cause many unpredictable, even life-threatening complications. Therefore, when there are warning signs of biliary stricture such as itchy skin, jaundice, dark urine, ... or at high risk of disease, the patient should go to a reputable hospital to be examined. accurate diagnosis and prompt and effective treatment.
With 14 years of experience in the field of Endoscopy - Gastroenterology, Doctor Dong Xuan Ha proficiently performs diagnostic gastrointestinal endoscopy techniques, emergency interventions and therapeutic interventions.

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