Goserelin Implant: Uses, indications and notes when using

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Goserelin Implant is used to treat prostate cancer in men. For women, Goserelin Implant is used to treat certain breast cancers or a certain uterine disorder, to thin the lining of the uterus in preparation for a procedure to treat abnormal uterine bleeding.

1. What does Goserelin Implant do?

What is the effect of Goserelin Implant? Goserelin Implant is used to treat prostate cancer in men and some breast cancers or a certain disorder of the uterus (endometriosis) in women. Goserelin Implants are also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding.

2. How to use the drug Goserelin Implant

Goserelin is an implant that releases a hormone slowly into the body. Goserelin is given by a healthcare professional by injection under the skin of the abdomen. The implant itself will be completely absorbed into the body within a few weeks or months. Get Goserelin and use it as directed by your doctor. Your dosage will be based on your medical condition and response to treatment.
The 3.6-milligram syringe is usually given every 4 weeks, the 10.8-milligram syringe is given every 12 to 13 weeks. Patients need to follow their dosing schedule carefully to get the most benefit from it. To help you remember, mark your calendar to keep track of when you get your next dose.
During the first few weeks of treatment, your hormone levels will go up and then go down. This is a normal response of your body to Goserelin. This can cause new or worsening symptoms such as increased pain and difficulty urinating in men during the first few weeks. In women, menstruation stops with regular use of Goserelin. Inform your doctor if regular menstruation continues after 2 months of treatment with Goserelin.
Usually, Goserelin will not need to be removed as the implant will be slowly and completely absorbed by your body. However, in the unlikely event you have serious side effects or other problems, your doctor may dismiss this medication.

3. Undesirable effects when using the drug Goserelin Implant

Some unwanted effects that may occur when using Goserelin Implant include:
Appearance of hot flashes Dizziness Headache Increased sweating Decreased interest, sexual ability Difficulty sleeping Nausea Changes breast size Vaginal dryness Hair loss At injection site: pain, swelling, bruising, bleeding Serious side effects such as vaginal burning pain, pain during sex in women, breast tenderness and tenderness, tenderness or broken bones, burning sensation in the feet/toes, swollen ankles/feet, unusual tiredness. In addition, there are signs of kidney disease (eg, change in urine output), stomach swelling or pain, and changes in mental status (eg, depression, mood swings, hallucinations).
Goserelin may cause blood sugar to rise, which may cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst or urination.
Rarely a very serious problem with the pituitary gland, but it can happen in the first hour to 2 weeks after your first dose of Goserelin. Get medical help right away if any of these very serious side effects occur such as: sudden severe headache, mental changes (such as confusion), vision changes, vomiting.
In men using Goserelin for prostate cancer, a rare but very serious urinary tract obstruction or spinal cord problem may occur such as spinal cord compression, especially during the first month first treatment. Tell your doctor right away if you have any of the following serious side effects: severe back pain, numbness or weakness in your limbs, even being unable to move, difficulty urinating, urinating blood .
Before prescribing, doctors always weigh the benefits of Goserelin Implant to outweigh the risk of side effects. However, some cases may still occur unwanted effects when taking Goserelin. Therefore, when unusual signs appear, especially when an allergic reaction occurs such as rash, itching or swelling of the face, tongue, throat, severe dizziness, difficulty breathing, ... In school In this case, the patient should immediately notify the doctor for timely treatment.

4. Some notes when using Goserelin Implant medicine

Some precautions when using Goserelin Implant include:
Tell your doctor if you have a history of allergy to Goserelin or LHRH or LHRH-like hormones (eg triptorelin), or any other allergies. Goserelin may contain inactive ingredients that can cause allergic reactions or other serious problems. Report medical history, especially abnormal vaginal bleeding, diabetes, chronic alcohol use, smoking, personal or family history of osteoporosis, heart disease (such as myocardial infarction) heart), high cholesterol and triglyceride levels, stroke, urinary blockage problems, and spinal cord problems in men. If you have diabetes, Goserelin can make it difficult to control your blood sugar. Check your blood sugar regularly as directed by your doctor to adjust your treatment regimen and lifestyle accordingly. Goserelin can cause QT prolongation, which affects heart rhythm. QT prolongation can rarely cause fast or irregular heartbeat and other symptoms (eg, severe dizziness, fainting). However, the risk of QT prolongation may be increased if you have certain medical conditions or are taking other medicines that can prolong QT. Before using Goserelin, tell your doctor or pharmacist all of the medications you are taking and any heart problems (such as heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart disease (electrocardiogram QT prolongation, cardiac death). High levels of potassium or magnesium in the blood can increase the risk of QT prolongation, especially with the use of certain medications such as diuretics, or conditions such as excessive sweating, diarrhea, or vomiting. Get medical help right away if any of these very serious side effects occur, including: fast and irregular heartbeat, severe dizziness, fainting, symptoms of a heart attack (such as pain) chest/jaw/left arm, difficulty breathing, unusual sweating), signs of stroke (eg, weakness on one side of the body, difficulty speaking, sudden vision changes, confusion) . Older adults may be more sensitive to the side effects of Goserelin, especially QT prolongation. Therefore, the use of the drug should be considered in the elderly. For women who are pregnant or planning to become pregnant, Goserelin should not be used. You should also not become pregnant while using Goserelin, because Goserelin can harm an unborn baby. Therefore, while using the drug, use effective methods of contraception such as condoms, diaphragms with spermicide for 12 weeks after stopping treatment or until menstruation returns. . Tests such as blood sugar tests, hormone levels, etc. should be performed regularly during treatment with Goserelin. In addition, if swallowed Goserelin can cause serious symptoms, requiring immediate medical intervention. It is important to take Goserelin on schedule. If you miss a dose, ask your doctor or pharmacist right away for the next dosing schedule.

5. Drug interactions

Drug interactions can reduce the effectiveness of Goserelin Implant drugs, or increase the effects of unwanted effects. Tell the doctor about all other medications the patient takes, including prescription, over-the-counter and herbal products. Do not start, stop, or change the dose of any medicine without your doctor's consent.

6. How to store Goserelin Implant medicine

Different brands of Goserelin will have different storage needs. Check the product package for instructions on how to store the medication's label. Keep Goserelin Implant out of the reach of children and family pets. When medicine is past its expiration date or cannot be used, dispose of it properly. Do not arbitrarily dispose of Goserelin Implant into the environment such as plumbing or toilet unless requested. Please consult your waste disposal company or pharmacist on how to safely dispose of Goserelin Implant to help protect the environment.
In summary, Goserelin Implant is effective in the treatment of prostate cancer in men and certain breast cancers or a certain disorder of the uterus (endometriosis) in women. Goserelin Implants are also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. However, Goserelin Implant can cause some unwanted effects and drug interactions, so tell your doctor what medicinal products you are taking to reduce the risk of side effects and increase the effectiveness of treatment. treat.

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Reference source: webmd.com