Dibenzyline: Uses, indications and cautions when using

This is an automatically translated article.

Dibenzyline is made in the form of capsules containing phenoxybenzamine 10mg. This is an alpha-blocker drug that inhibits nerve signals to control blood pressure in cases of high blood pressure caused by adrenal tumors, called phaeochromocytoma. Dibenzyline is often used when other alternative treatments are not suitable.

1. What is Dibenzyline?

Phaeochromocytoma is a pathology in which a tumor exists in the adrenal medulla (adrenal medulloblastoma). As a result of this pathology, a large amount of chemicals are released from the adrenal glands, constricting the peripheral arteries. From there, the systemic blood pressure will increase significantly with each episode occurring continuously during the day.
The treatment of choice in patients with pheochromocytoma is early surgical removal of the tumor. Once the tumor is removed, the blood pressure and related problems will go into remission and disappear completely without further treatment. However, in cases where immediate surgical intervention is not possible, Dibenzyline or Phenoxybenzamine will be prescribed as a short-term option for high blood pressure in preparation for the adrenalectomy. planned in the future.
Dibenzyline's mechanism of action is by blocking excitatory receptor sites on blood vessels, called alpha receptors. From there, the drug will reduce blood pressure as well as improve other sympathomimetic symptoms caused by adrenal myeloma.
In addition, the drug Dibenzyline in particular or the group of alpha-adrenergic antagonists in general is particularly effective in regulating the reflexes of smooth muscle and exocrine glands, as used in the treatment of excessive sweating.

2. Things to note before taking Dibenzyline

Do not take Dibenzyline or Phenoxybenzamine if you have one of the following conditions:
Are allergic to Phenoxybenzamine or any other ingredient Have ever had a stroke Have had a heart attack or have a blood clot in the coronary arteries from within last month. In addition, when prescribing Dibenzyline, doctors also need to be especially careful if: The patient is being treated for shock or abnormally low blood pressure and cannot maintain an appropriate level of blood supply. May Have angina Have heart disease or heart failure, for example symptoms such as swollen ankles Thickening of the artery walls including those in the brain Have had problems with kidney damage In addition, the patient It is also important to inform your doctor about any medications you are taking to avoid dangerous drug interactions, especially cardiovascular drugs, such as beta-blockers (eg, Atenolol, bisoprolol), and blockers. ACE inhibitors (eg, Captopril, enalapril) and calcium channel blockers (eg, Amlodipine, lacidipine).
For women who are pregnant, planning to become pregnant and breast-feeding, do not take Dibenzyline or phenoxybenzamine without consulting a specialist.
For driving and using machines, because Dibenzyline or phenoxybenzamine can make the patient feel dizzy or lightheaded. If this happens, talk to your doctor before driving or using machines so that your medication can be adjusted accordingly.

3. How to use Dibenzyline?

The drug Dibenzyline has the ingredient phenoxybenzamine, is made in the form of capsules for oral use and has the usual strength of 10mg.
The important thing in using Dibenzyline is to take it at the right time and follow the dosage as directed by your doctor. If you are unsure, consult your doctor or pharmacist.
The usual adult dose of Dibenzyline will start with one tablet a day. Elderly patients may require a lower dose level.
Phenoxybenzamine 10mg capsules are not usually used for children, but when needed, the dosage will be calculated according to the child's weight. Your doctor may change the dose of the drug depending on how well this treatment works, or may prescribe a different medication with a more convenient dosage form.
After being assigned to start treatment with Dibenzyline, patients need to be periodically examined to monitor the effects and determine how long to take the drug.
In case of taking more than one tablet of Dibenzyline, the patient should contact a doctor or go to the nearest hospital immediately.
If you forget to take Dibenzyline, take a dose as soon as you remember and continue with the next dose at the specified time of day. However, in order for the drug to work and maintain the best effect, the patient needs to avoid forgetting to take the medicine. At the same time, absolutely do not arbitrarily take twice the prescribed dose to make up for the missed dose.

4. Possible side effects when taking Dibenzyline

Similar to other medications, Dibenzyline can cause side effects, although not everyone who takes it has them.
Possible side effects include:
Dizziness and heart palpitations when suddenly standing up from a lying or sitting position Congested nose Stomach pain or diarrhea Failure to ejaculate during intercourse Pupil contraction Fatigue or feel weak. Accordingly, if there are any serious or mild side effects caused by Dibenzyline, but the patient cannot tolerate it, it is necessary to let the doctor or pharmacist know for timely intervention, sometimes it is necessary to treat the patient. appropriate alternative treatments.
In summary, Dibenzyline or phenoxybenzamine is an alpha blocker for high blood pressure indicated in the treatment of pheochromocytoma, control of sympathomimetic symptoms while waiting for surgery. In order to maintain control of episodes of hypertension as well as excessive sweating, patients need to strictly follow the doctor's instructions, avoid forgetting drugs and may consider combining with beta-blockers, especially when the heart rate is too fast.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

References: webmd.com, accessdata.fda.gov, medlineplus.gov, patient.info