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Posted by Dr. Nguyen Van Dinh - Head of Allergy - Clinical Immunology Unit and Doctor Le Duy Cuong, Laboratory - Vinmec Times City International HospitalThe 23 antinuclear antibody test has a very important role in determining the type of autoantibodies, assisting doctors in accurately diagnosing autoimmune diseases, especially rheumatoid diseases.
1. What is the ANA 23 profile test?
ANA 23 profile is a test that allows simultaneous determination of 23 types of antinuclear antibodies with 23 different antigens in patient serum/plasma, including: dsDNA, nucleosomes, histones, SS-A, Ro- 52, SS-B, nRNP/Sm, Sm, Mi-2α, Mi-2β, Ku, CENP A, CENP B, Sp100, PML, Scl-70, PM-Scl100, PM-Scl75, RP11, RP155, gp210, PCNA and DFS70 .
The identification of these autoantibodies assists the clinician in the diagnosis of various autoimmune diseases such as: Sharp's syndrome (or mixed connective tissue disease), systemic lupus erythematosus, and systemic lupus erythematosus. , Sjogren's syndrome, progressive systemic sclerosis, polymyositis/dermatomyositis, overlapping syndromes, limited form of progressive systemic sclerosis (CREST syndrome) and primary biliary cirrhosis.
ANA 23 profile là xét nghiệm xác định 23 kháng thể - kháng nguyên
2. When is the ANA 23 profile test ordered?
A physician may order an ANA 23 profile test when a patient has symptoms that suggest the above autoimmune conditions, such as:
Joint pain; Muscle pain; Body fatigue; Recurrent fever; Prolonged fever ; Rash; Skin is sensitive to light; Numbness and tingling in the hands or feet; Hair loss; Congenital atrioventricular block; Idiopathic liver and kidney damage.
3. Meaning of ANA 23 . test results
Antinuclear antibodies against many components of the cell nucleus. These components include nucleic acids, nuclear proteins, and ribonucleoproteins. Detection of autoantibodies against one or more autoantigens is an important factor in the diagnosis of autoimmune diseases, especially rheumatic diseases. The prevalence of antinuclear antibodies in rheumatic diseases ranges from 20-100% (20-40%). Therefore, differential diagnosis of ANA to find autoantibodies against nuclear antigens is necessary to identify each disease. ANA analysis is also useful in the diagnosis of other autoimmune diseases such as primary cholangitis, autoimmune hepatitis.
Xét nghiệm ANA 23 profile được thực hiện trên Hệ thống EUROBlotOne cung cấp giải pháp đổi mới dựa trên công nghệ lineblot
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A system of modern and advanced medical equipment, possessing many of the best machines in the world, helping to detect many difficult and dangerous diseases in a short time, supporting the diagnosis and treatment of doctors the most effective. The hospital space is designed according to 5-star hotel standards, giving patients comfort, friendliness and peace of mind.
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