Aloxi Vial drug: Uses, indications and notes when using

This is an automatically translated article.

Aloxi vial is a sterile, clear, colorless, non-pyrogenic, isotonic buffer solution for intravenous administration. It is used to prevent nausea and vomiting caused by cancer treatment with drugs (chemotherapy).

1. What is alox vial?

The drug aloxi vial (palonosetron hydrochloride) is an antiemetic and antiemetic. It is a serotonin subtype 3 (5-HT3) receptor antagonist with strong binding affinity for this receptor. Palonosetron works by blocking serotonin, a natural chemical in the body that causes vomiting.
Cancer chemotherapy can lead to high rates of nausea and vomiting, especially when certain agents are used, such as cisplatin. The 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and in the center of the chemoreceptor trigger zone of the anal region. Many claim that the main cause of nausea and vomiting is chemotherapy. By releasing serotonin from the enterochromaffin cells of the small intestine, the subsequently released serotonin activates 5-HT3 receptors located on the vagus inducers to initiate the vomiting reflex.
Postoperative nausea and vomiting are influenced by many factors related to the patient, surgery, and anesthesia and are triggered by 5-HT release in a chain of neurological events involving the whole system. central nervous system and gastrointestinal tract. The 5-HT3 receptor has been shown to selectively participate in the vomiting response.

2. Uses of aloxi

Aloxi vial is used to prevent possible nausea and vomiting:
Immediately after taking certain anti-cancer drugs After taking some anti-cancer drugs Immediately after recovering from anesthesia after surgery jutsu

3. Use of aloxi

Aloxi is given into your vein by intravenous line. Medicines are only given to you in a hospital or clinic when prescribed. Aloxi is usually injected into your vein about 30 minutes before you take your anti-cancer medicine (chemotherapy) or right before anesthesia for surgery.
Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

4. Note when using aloxi

Do not take Aloxi if you are allergic to any of the ingredients in the medicine. The active ingredient is palonosetron hydrochloride. Read the leaflet carefully for the complete list of ingredients in Aloxi. Aloxi has not been studied in children under 18 years of age.
Inform your doctor about your current condition such as:
For pregnant women: It is not known whether Aloxi can harm your unborn baby. Breast-feeding : It is not known whether Aloxi passes into your milk and could harm your baby. You should choose to take Aloxi or breastfeed, but not both. Tell your doctor about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements.

5. Side effects of aloxi

The most common side effects of Aloxi are headache, constipation, diarrhea, dizziness. Serious allergic reactions, such as anaphylaxis, may occur when aloxi is taken. Call emergency medical help right away if you have any of the following symptoms: hives, facial swelling, trouble breathing, chest pain. Serotonin syndrome: Serotonin syndrome can occur with medicines known as 5-HT3 receptor antagonists, including Aloxi, especially when used with medicines used to treat depression and migraine headaches such as serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors, monoamine oxidase inhibitors (MAOIs), and some others. Tell your doctor or nurse right away if you have any of the following symptoms of serotonin syndrome: agitation, hallucinations, confusion or coma; fast heartbeat or unusual and frequent changes in your blood pressure; dizziness, sweating, flushing, or fever; tremors, muscle stiffness, muscle twitching, overactive or uncoordinated reflexes; convulsions, nausea, vomiting, or diarrhea.
The above are not all possible side effects of Aloxi. See your doctor for medical advice about medication side effects.
Vinmec International General Hospital is one of the hospitals that not only ensures professional quality with a team of leading medical doctors, a system of modern equipment and technology. The hospital provides comprehensive, professional medical examination, consultation and treatment services, with a civilized, polite, safe and sterile medical examination and treatment space.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

Reference source: webmd.com