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Sulpiride stada 50mg belongs to the Benzamide group, has antipsychotic and antidepressant effects through selective blockade of Dopamine D2 receptors in the brain. Let's learn more about what Sulpiride stada 50mg is, what Sulpiride stada 50mg does in the article below.1. What is Sulpiride Stada 50mg?
Sulpiride stada 50mg has the main ingredient is Sulpiride. Sulpiride is a selective dopamine D2 receptor antagonist indicated for the treatment of chronic and acute schizophrenia. Sulpiride first appeared in the published literature in 1967. Clinical studies have shown a more effective treatment for the negative symptoms of schizophrenia than the positive symptoms at low doses, although the effect is more equal at higher doses.Sulpiride is not approved by the FDA, Health Canada or the EMA; although it is approved in individual European countries.
Sulpiride is a selective Dopamine D2 antagonist indicated for the treatment of acute and chronic schizophrenia, essentially a substituted Benzamide derivative. The drug has a short duration of action because it is administered twice daily and a long duration of treatment because patients have survived with a single dose of up to 16g. Patients should be counseled about myoclonus, extrapyramidal reactions, and neuroleptic malignant syndrome.
Silicon studies have shown that Sulpiride can interact with the amino acid residues Asp-119 and Phe-417 of these receptors. It is estimated that D2 receptors should be occupied 65 - 80% for optimal treatment and minimal side effects.
The oral bioavailability of Sulpiride is 27 ± 9%. Doses of 100 - 108 mg of Sulpiride reached a maximum C of 232 - 403 ng/mL, with a maximum T of 8.3 hours. In another study, the AUC for the oral dose of 100 mg Sulpiride was 1156 ± 522 h*ng/mL and for the intravenous dose 3981 ± 813 h*ng/mL. 95% of a dose of Sulpiride is not metabolized. An intravenous dose of Sulpiride is eliminated 70 ± 9% in the urine within 36 hours, while an oral dose of 27 ± 9% is excreted in the urine. In both cases, the dose was recovered as the parent compound unchanged. Sulpiride half-life studies were performed with only a small number of subjects. Therefore, the mean half-life could be 7.15 hours 4 to 8.3 hours.
2. What are the effects of Sulpiride 50mg?
2.1. The effect of the drug Sulpiride Stada 50mg
For symptomatic adults who do not respond to standard therapy, sulpiride is effective for short-term treatment. Physical mental disorders. Inhibitory nervous state. Severe behavioral disorders such as: agitation, self-injury, imitation of stereotypes in children over 6 years old, autistic disorder.2.2. Dosage of Sulpiride Stada 50mg
50 - 150 mg/day for adults with symptoms of anxiety, for a maximum of 4 weeks. Severe behavioral disorders in children: 5 - 10 mg/kg body weight/day. The total daily dose should not exceed 150 mg. The starting dose is 50-100 mg/time x 2 times/day for the elderly. The dose can then be adjusted as needed during treatment. For patients with renal impairment: Creatinine clearance (Clcr) from 30 to 60 ml/min: the dose is 2/3 of the normal dose or can prolong the interval between doses 1.5 times compared to that of humans. normal. Clcr from 10 - 30 ml/min: dose is 1/2 of the normal dose or can prolong the interval between doses 2 times compared to normal people. Clcr less than 10 ml/min: the dose is 1/3 of the normal dose or can prolong the interval between doses 3 times compared to normal people. The above dosage information should only be used for reference, depending on the condition and progress of the disease, the dose may be changed. Consult with your treating physician to decide on the best dose of treatment.3. How to use Sulpiride stada 50mg effectively
3.1. Contraindications of Sulpiride Stada 50mg
There is a history of hypersensitivity to any ingredient of Sulpiride. Adrenal myeloma. Acute porphyria metabolism disorder. Central nervous system depression in cases: coma, alcohol poisoning and neuroleptic drugs. Cancer of the breast or pituitary gland. Patients with an overdose of Sulpiride may experience hypotension, sinus tachycardia, cardiac arrhythmias, dystonia, CNS depression, hallucinations, vomiting, agitation, arrhythmias, and watery secretions. foam, as well as increased muscle tone, increased reflexes, and muscle relaxation reflexes. Patients should receive symptomatic and supportive treatment.If you miss a dose, take it when you remember if the time to the usual time is short. If the time from remembering to the time of regular dosing is too long, skip the missed dose and wait for the next dose. Do not arbitrarily double the dose when you forget or do not increase the dose compared to the original indication.
3.2. Side effects when using Sulpiride 50mg
Some common side effects are insomnia or drowsiness, hyperprolactinemia, increased lactation, amenorrhea or menstrual disturbances. Uncommon side effects such as: extrapyramidal overstimulation syndrome, increased QT interval can cause arrhythmia or torsades de pointes, Parkinson's syndrome. A few rare symptoms include gynecomastia in men, psychotropic malignant hyperthermia syndrome, dyskinesia, bradycardia/arrhythmia, orthostatic hypotension, hypothermia or sensitization with light or cholestatic jaundice. When unusual symptoms appear when using the drug, seek the nearest medical help for timely handling.3.3. Drugs and foods that interact with Sulpiride
Levodopa and other neuroleptics may have a competitive antagonism of sulpiride Alcohol and alcoholic beverages will enhance the effect of sedatives Has a synergistic effect with antihypertensive agents and may therefore cause orthostatic hypotension. Some other CNS depressants have interactions such as: antidepressants, antihistamines, anxiolytics, barbiturates, Clonidine family drugs, sleeping pills, Methadone if used in combination with Sulpiride to increase depression CNS depression may lead to adverse effects on people who are driving or operating/operating machinery. Sucralfate, Antacid and Magnesium hydroxide reduce the effect of Sulpiride, so it is not recommended to use these two drugs at the same time. In particular, do not use Sulpiride for pregnant women, especially in the first 16 weeks of pregnancy. The drug is also excreted in breast milk, so it may cause side effects in the baby if the baby is breastfed.3.4. What should you do in case of an emergency or overdose?
In the event of an emergency or overdose, immediately call 911 or go to the nearest local health station.What should you do if you miss a dose?
If you forget to take a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take twice the prescribed dose.
3.5. What should you know before taking Sulpiride?
Before using Sulpiride, tell your doctor if you have the following conditions:Hypomania - this is a mood change that manifests as irritability, anger, irritability and decreased need go to bed Heart problems - if you or a family member has heart problems, your doctor may perform heart and blood tests before prescribing medication Epilepsy Parkinson's Disease kidneys or liver You are elderly Dementia Have high blood pressure Have had a stroke You or someone in your family have a history of blood clots, as medicines such as this will cause blood clots Severe shortness of breath Asthma Weakness (excessive weakness) or prostate enlargement Jaundice (or eyes) Aggressive behavior or agitation Low blood potassium levels Sulpiride can cause you are more sensitive to sunlight, so cover up and use sunscreen when out in the sun. In addition, the drug is contraindicated in the following cases:
Hypersensitivity to Sulpiride or any ingredient in the drug Suspected or present Prolactin-dependent cell tumor, such as pituitary tumor, breast cancer Adrenal medulloblastoma , acute porphyrin metabolism disorders Patients with Barbiturates, Opiates, alcohol poisoning
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