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Zyvox belongs to the group of antibiotics against infections, with the main ingredient being Linezolid, which selectively inhibits bacterial protein synthesis with a spectrum of action against gram (+) and anaerobic bacteria. The drug is often indicated in the treatment of various bacterial infections such as pneumonia, skin infections... that are resistant to other antibiotics.1. What is Zyvox?
The main ingredient Zyvox is Linezolid, which binds to ribosomes and cells. Linezolid's mechanism of action is to target ribosomes, block protein synthesis, and kill bacteria. Linezolid is a synthetic antibiotic used in the treatment of infections caused by pathogens such as staphylococcus, including resistant bacteria. In addition, skin infections, pneumonia ... can be treated with Linezolid.However, in rare cases Linezolid can lead to a decrease in the production of blood cells. In addition, linezolid may be harmful to milo chondria, a cell control organ that contains ribosomes similar to bacterial ribosomes.
2. Indications for the drug Zyvox
Zyvox is usually indicated in the following cases:
Infections caused by Vancomycin-resistant Enterococcus faecum, including cases of ongoing bacteremia. Nosocomial pneumonia is caused by Staphylococcus aureus both methicillin-sensitive and resistant strains. Complicated skin infections caused by Staphylococcus aureus, S.pyogenes, S.agalactiae. Uncomplicated skin infections caused by Staphylococcus aureus (both Methicillin-sensitive and resistant strains), Streptococcus pyogenes. Community-acquired pneumonia caused by Penicillin-susceptible Streptococcus pneumoniae, including cases of bacteremia or Staphylococcus aureus (only effective with Methicillin-susceptible strains).
3. Contraindications to the drug Zyvox
Concomitant use with Monoamine Oxidase inhibitors; Uncontrolled high blood pressure; Pheochromocytoma; Thyroid toxicity ; Are taking direct/indirect sympathomimetic drugs, vasopressors, dopaminergic drugs; Patients with carcinoid syndrome ; Are taking serotonin reuptake inhibitors, tricyclic antidepressants, 5-HT1 serotonin receptor agonists, Meperidin, and Buspirone.
4. Dosage of Zyvox
Zyvox is usually given intravenously or can be switched to orally without dose adjustment. Depending on the subjects and treatment goals, the dose of Zyvox used will be different, specifically as follows:
Adults and children over 12 years old: 600mg intravenously every 12 hours; Children under 12 years old: 10 mg/kg IV every 8 hours; Use 10-14 days if you have hospital-acquired pneumonia, community-acquired pneumonia, skin and soft tissue infections (including sepsis); 14-28 days for Enterococcus infections, including vancomycin-resistant Enterococcus with sepsis; Zyvox drug does not need to adjust the dose in the elderly, patients with liver and kidney failure.
5. Side effects of the drug Zyvox
In some patients when using Zyvox, side effects may occur such as:
Abdominal pain, bloating, abdominal cramps; Diseases caused by Candida fungi ; Headache, change in taste; Diarrhea, nausea, vomiting; Anemia, leukopenia, thrombocytopenia, reversible pancytopenia; Optic neuropathy is common with long-term use (more than 28 days).
6. Be careful when using Zyvox
Some general notes when using Zyvox include:
Use Zyvox only when the benefits outweigh the risks to the fetus; Zyvox should be used with caution in lactating women; Zyvox can cause side effects such as headache, loss of vision when used, so those who drive or operate machinery need to be careful; Blood counts must be monitored while using Zyvo; Pseudomembranous colitis, Clostridium difficile diarrhea have been reported with the drug; Immediately notify your doctor if you notice any visual abnormalities after using Zyvox. Common drug interactions of Zyvox include:
When Zyvox is combined with Pseudoephedrine hydrochloride drugs, Phenylpropanolamine hydrochloride may cause a mild reversible increase in blood pressure; Very rarely, serotonin syndrome has been reported with concomitant use of Serotonergic drugs; Drinks and foods with high tyramine content can cause hypertension, avoid tyramine > 100mg per meal. Above is information about uses, dosage and precautions when using Zyvox. To ensure the safety of your health and maximize the effectiveness of treatment, you need to take the medicine exactly as directed by your doctor.
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