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Drug C.ales 20mg is a drug to treat erectile dysfunction, the drug has the effect of increasing the time of penile erection when stimulated. To learn more about the drug, please learn about the drug through the article below.1. Uses of the drug C.ales 20mg
C.ales 20mg drug contains the main ingredient Tadalafil 20mg and is made in the form of film coated tablets. The drug is indicated for the treatment of erectile dysfunction in men.Mechanism of action: Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP), specifically on the enzyme phosphodiesterase type 5 (PDE5). When sexual stimulation leads to local release of nitric oxide, Tadalafil's inhibition of PDE5 increases cyclic GMP concentrations in the corpus cavernosum. This leads to smooth muscle relaxation and helps increase blood flow to the penile tissue, which in turn causes an erection. Note that Tadalafil does not cause an erection in the absence of an aphrodisiac.
Tadalafil selectively inhibits PDE5: PDE5 is an enzyme found in cavernous smooth muscle, vascular and visceral smooth muscle, skeletal muscle, platelets, kidney, lung, and cerebellum.
2. Indications and contraindications when using C.ales 20mg
Drug C.ales 20mg is indicated for use in the following cases:Treatment of erectile dysfunction in men. A man's penis is not erect enough for sexual desire. The erection time is not enough to be able to have sex. Contraindications: Do not use the drug in the following cases
Women and children under 18 years of age. Patients with a history of hypersensitivity to tadalafil or to any of the excipients. Patients with recent myocardial infarction within 90 days, patients with a history of unstable angina or angina occurring during intercourse. The patient had recently developed severe heart failure within the previous 6 months. Contraindicated in combination with nitrites or organic nitrates. Uncontrolled arrhythmias, hypotension (<90/50 mmHg) or uncontrolled hypertension.
3. Dosage and how to use C.ales 20mg
Usage: The drug is taken orally. Take the pill with plenty of water and usually take it 30 minutes before sex.Dosage:
The usual dose is to take 1 tablet per day with plenty of water. No dose adjustment is required in the elderly, in patients with mild renal or hepatic impairment. Patients with renal impairment: Creatinine clearance 30 - 50 ml/min, the maximum dose is 1/2 tablet (10 mg)/time for 48 hours. Creatinine clearance < 30 ml/min or hemodialysis: not use C.ales Patients with hepatic impairment: Moderate hepatic impairment: Maximum dose of 1/2 tablet/time/day. In patients taking strong inhibitors of the cytochrome P450 isoenzyme CYP3M, the dose of Tadalafil should not exceed 10 mg once every 12 hours.
4. Undesirable effects when taking C.ales 20mg
When using C.ales 20mg, you may experience some of the following side effects:Common side effects: Headache, flushing, nose bleeding, gastroesophageal reflux, slow digestion, pain back, muscle pain or limb pain. Uncommon side effects: Hypersensitivity reactions (rash, difficulty breathing, abdominal pain, swelling of the face, swelling of the lips,...); dizzy; blurred vision, eye pain, ringing in the ears; increased heart rate; hypotension (usually occurs in patients taking antihypertensive drugs), hypertension; difficulty breathing, nosebleeds; increased sweating; hematuria; penile bleeding, colored semen; chest pain. Rare: Causes angioedema; stroke (in case of hemorrhage), syncope, transient ischemic attack, migraine, seizure, transient amnesia; visual impairment, eyelid swelling, conjunctival congestion, non-arteritis optic nerve ischemia, retinal vein occlusion; hearing loss occurs suddenly; myocardial infarction, unstable angina, ventricular arrhythmias; Steven - Johnson syndrome, exfoliative dermatitis; prolonged penile erection; sudden cardiac death. If during use appear any unwanted effects, please notify your doctor to receive integrated support. In case of serious side effects such as hypersensitivity reactions, stroke, angioedema, etc., it is necessary to seek medical attention immediately for timely treatment.
5. Notes when using C.ales
To ensure safety and effectiveness when taking this medicine, tell your doctor about any allergies, medical history, and all medications and foods you are taking. Do not overdose, use only once a day maximum. Because there is no safety evidence for multiple daily use. Drug or other substance interactions can occur when drugs are taken together. Caution should be exercised when co-administering the following drugs: Combination with HIV Protease inhibitors increases peak plasma concentrations and elimination half-life of Tadalafil. Combination with Rifampicin causes a decrease in Tadalafil concentrations. Antihypertensive drugs can increase the side effects of lowering blood pressure. Alcohol: A dose of 0.7g/kg taken no more than 10 minutes before taking the drug can cause orthostatic hypotension which is manifested by tachycardia, dizziness and headache. Theophylline: Concomitant use increases the concentration of Theophylline slightly, causing an increase in heart rate. Antacids: Decreased rate of absorption of Tadalafil. Overdosage: May cause symptoms similar to unwanted effects when taken at low doses, if high doses can cause serious effects. It is necessary to stop the drug and go to a medical facility for timely treatment. Note when using the drug for people with cardiovascular disease, people with hereditary degenerative retinal disorders or retinitis pigmentosa, deformed penis anatomy. It should be combined with a regular diet to control the disease. Store in a dry place, the temperature is below 30 degrees Celsius, should avoid direct sunlight. Keep medicine out of reach of children. Hopefully, through the article you have understood about the effects of C.ales and the notes when taking the drug. The drug is used under the prescription of a doctor, so you should not arbitrarily use it without a prescription.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
