Uses of Praxilene tab 200mg

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1. What is Praxilene 200mg?

Praxilene tab 200mg is a peripheral vasodilator drug, the drug is made in the form of film-coated tablets with the main ingredient in each tablet is 200mg Naftidrofuryl hydrogen oxalate equivalent to 162mg naftidrofuryl.
Naftidrofuryl produces two synergistic effects leading to a diffuse anti-ischemic effect:
At the vascular level: This active substance acts as a specific 5-HT2 receptor antagonist, naftidrofuryl potentiates the vasoconstrictor and platelet pre-aggregation effects of serotonin. At the cellular level: As an activator of ATP production, naftidrofuryl enhances the metabolism of ischemic cells. Praxilene tab 200mg is indicated in the following cases: Chronic peripheral arterial occlusion of the lower extremities (stage II).
Praxilene tab 200mg is contraindicated in the following cases:
People with hypersensitivity to any ingredient of the drug. Patients with known hyperoxaluria. People with a history of recurrent calcium kidney stones

2. Dosage and how to use Praxilene tab 200mg

Praxilene tab 200mg is used orally. The patient should take the drug with a meal, swallow the tablet whole without chewing, and drink it with a large glass of water.
Dosage of Praxilene 200mg should be according to the doctor's prescription. Reference dose is as follows:
Peripheral artery disease of the lower extremities: Use a dose of 1 tablet x 3 times/day, equivalent to 600mg naftidrofuryl/day. Treatment with Praxilene tab 200mg only had a moderate effect on improving the patient's walking distance for about 6 months after starting treatment. Therefore, patients should only use Praxilene 200mg as an adjunct to other therapies or recommended methods for treatment in stage 2 of chronic peripheral arterial occlusive disease (e.g. control of peripheral artery disease). cardiovascular risk factors, regular exercise, smoking cessation).
The patient's response to treatment should be re-evaluated after 6 months of using Praxilene tab 200mg and the decision should be re-evaluated whether to continue treatment in case there is no improvement in the disease's symptoms.
In the case of an overdose of Praxilene tab 200mg can cause acute intoxication that may have manifestations such as decreased cardiac conduction, confusion and convulsions. Treatment of drug overdose should be carried out with intestinal lavage, activated charcoal can be used if necessary, cardiovascular function should be monitored and symptomatic treatment. Seizures can be controlled with diazepam.

3. Side effects of medicine Praxilene tab 200mg

During the use of Praxilene tab 200mg, you may encounter some side effects of the drug.
Uncommon side effects of Praxilene 200mg include:
Diarrhea Nausea, vomiting. Epigastric pain Rash Rare side effects of Praxilene 200mg include: Liver damage. Cases of severe liver injury with acute cytolytic type have been reported.
Very rare side effects of Praxilene 200mg include: Calcium oxalate kidney stones
Unknown side effects of Praxilene 200mg include:
Esophagitis caused by the patient taking the drug without drinking water right before going sleeping, causing the pill to get stuck in the neck causing local inflammation. Oral mucosal ulcers If you experience any side effects of Praxilene 200mg, please inform your doctor immediately or go to the nearest medical facility for timely treatment.
Praxilene tab 200mg is a drug used in the treatment of chronic peripheral arterial occlusion. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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