This is an automatically translated article.
Melphalan 2mg drug is prepared in the form of tablets and lyophilized powder with 10ml of solvent for injection. The drug is used in the treatment of certain cancers. The drug interferes with the growth of cancer cells. Melphalan may be used in combination with certain other medicines to treat cancer. Immediately refer to the article below for more useful information about the use and note of the drug when using.
1. Uses of Melphalan 2mg
Melphalan 2mg drug is prescribed by doctors in the treatment of cancer related to myeloma, ovarian such as: Unresectable epithelial ovarian carcinoma, breast cancer and malignant melanoma...
Mechanism of action The action of drugs slows or inhibits the growth of cancer cells.
However, the drug is not allowed to be prescribed in the following cases:
Patients with systemic infections Patients with severe bone marrow failure People with a history of drug resistance People with hypersensitivity to Melphalan or any of the ingredients
2. Usage and dosage of Melphalan 2mg
2.1. How to use Melphalan is a prescription drug, so patients need to follow the directions on the label or the doctor's orders. The patient must absolutely not use an overdose or a dose smaller than prescribed. Do not prolong use unless directed by your doctor.
In fact, Melphalan can be effective after several months of use. Women who are pregnant or intend to become pregnant should not take this medicine because Melphalan can be absorbed through the skin and lungs, causing harm to the unborn baby.
2.2. Dosage The dosage of Melphalan 2mg can be adjusted depending on the patient's health condition and the purpose of treatment. The following are the recommended dosages:
For the usual adult dose for myeloma
Intravenous dose: 16mg/m2. The infusion time can last from 15 to 20 minutes. The drug is used every 2 weeks, 4 doses, after full recovery, a break of about 4 weeks. Usual oral dose: 6mg, 1 time / day. After 2–3 weeks of treatment, you should stop taking the drug for a maximum of 4 weeks, during which time you should follow a careful blood count check. When white blood cell and platelet count increase, you take a maintenance dose of 2mg per day. Usual Dose for Women with Ovarian Cancer
Use in the treatment of epithelial ovarian cancer: General regimen: 0.2 mg/kg orally daily for 5 days as a single course. This process is repeated every 4–5 weeks depending on hematological tolerability.
Dosage of Melphalan for children should consult a doctor.
In case of overdose, the patient should immediately go to the nearest medical facility for examination and measures to remove the medicinal properties of the drug from the body. If you miss a dose, use it as soon as possible. However, if the missed dose is close to your next dose, skip it and take it as planned. Never use a double dose to avoid an overdose.
3. Melphalan side effects
Melphalan 2mg medicine can cause some side effects for patients such as: nausea, vomiting, digestive disorders, ... In many cases, doctors can prescribe drugs to reduce nausea and vomiting. . If these symptoms persist and do not improve, the patient should notify the doctor.
In addition, women when using the drug may experience some symptoms: stopping menstruation, dark urine ...
The above are not all side effects caused by Melphalan, so During the use of the drug, if the patient experiences any unusual symptoms, they should notify the doctor.
4. Note when using the drug Melphalan
To use drugs safely, patients need to inform their doctors about the medicines they are using. Your doctor will also need to know if you are allergic to any of the ingredients or have any bleeding problems, kidney problems, or radiation treatment. From there, the doctor will decide if the patient is suitable for taking Melphalan.
According to experts, Melphalan can increase the risk of infection or make the infection worse.
Pregnant women should not use Melphalan, especially during pregnancy, the drug can cause embryo death and teratogenicity. Women who are in the process of giving birth and using the drug need to use birth control pills.
Combined with nalidixic acid can cause death by causing inflammation of the small intestine - colon bleeding.
Taking high doses of melphalan with ciclosporin is nephrotoxic, damaging to kidney function and potentially harmful. Therefore, patients need to adhere to the dosage instructions.
Currently there are not enough data to prove whether Melphalan passes into breast milk or not, but to ensure the safety of the infant's health, women taking the drug should stop breast-feeding.
5. Melphalan drug interactions
When combining Melphalan with some other drugs can cause interactions. Drug interactions can increase side effects or decrease the effectiveness of the drug. To avoid this situation, the patient needs to inform the doctor about the medicines you are taking. Specifically:
Cimetidine and H2 antagonists reduce gastric pH, thus reducing the bioavailability of melphalan by 30%. Ciclosporin increases the incidence of nephrotoxicity of melphalan. In addition, Melphalan may change the way it works when taken with food, alcohol, and tobacco. To be safe when using the drug, the patient should consult with the doctor about the use of the drug with foods, alcohol and tobacco.
Finally, Melphalan needs to be stored according to regulations to ensure the effectiveness of the drug. According to the instructions, Melphalan should be stored at room temperature, away from moisture and sunlight.
Melphalan 2mg drug is effective in the treatment of cancer. Medicines are only effective when used in the correct dosage as prescribed by the doctor.
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