Uses of Flagentyl 500mg

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1. What disease does Flagentyl 500mg treat?

What is Flagentyl 500mg? The drug has the main ingredient Secnidazole 500mg. Active ingredient Secnidazol is an antibiotic, specifically against protozoa including trichomonas, amoeba, giardia. The mechanism of action of the drug is to kill bacteria through toxic metabolites, then destroy the DNA chain of bacteria and protozoa.
Indications to use Flagentyl 500mg:
Treatment of vaginitis, urethritis caused by trichomonas vaginalis; Treatment of liver amoebiasis; Treatment of intestinal amoebiasis; Treatment of diseases caused by Giardia. Contraindications to using Flagentyl 500mg:
Patients with hypersensitivity to imidazol derivatives or other components of the drug; The mother is in the period of breastfeeding; People who are allergic to flour (a condition other than gluten malabsorption syndrome).

2. Usage and dosage of Flagentyl 500mg

Usage: Orally.
Dosage:
Vaginitis and urethritis caused by trichomonas vaginalis: Adults take a single dose of 4 tablets (2g) before meals; Intestinal amoebiasis: Acute amoebic infection (active form of Entamoeba histolytica): Adults take a single dose of 4 tablets (2g), taken before meals. Children use a dose of 30mg/kg/day, orally as a single dose, for only 1 day of treatment; Amoebic infections without symptoms (minuta and cystic): Take the daily dose as above for 3 days; Liver amoeba: Adults: Take a dose of 3 tablets/day (1.5g/day), orally once or divided into several times a day, taken before meals, treat for 5 days; Children: Take a dose of 30mg/kg/day, take 1 time or divided into several times a day, drink at the time before meals, treat for 5 days; In case of hepatic amebiasis with pus, it is recommended to perform drainage of pus from the abscesses at the same time as the use of Secnidazole; Diseases caused by Giardia infection: Children use a dose of 30mg/kg/day, orally as a single dose, for only 1 day of treatment; For children under 6 years old: Use oral solution form. Missed dose: If you forget to take a dose of Flagentyl 500mg, you should take this dose as soon as you remember. However, if it is almost time for the next dose, the patient should skip the missed dose and take the next dose as scheduled. If you need more information, you can consult your doctor.
Overdose: No information is available on cases of Secnidazol overdose. Symptoms of overdose with Metronidazole (imidazole derivative) are vomiting, ataxia, mild disorientation. When using Flagentyl 500mg drug overdose, the patient is treated symptomatically and supportively at the hospital. Secnidazole can be eliminated by induction of vomiting, gastric lavage, use of activated charcoal, or increased frequency of bowel movements. Seizures can be controlled with diazepam and phenytoin.

3. Flagentyl 500mg . side effects

When using Flagentyl 500mg, patients may experience some side effects such as:
Digestion: Nausea, vomiting, pain in the stomach, stomatitis, glossitis, metallic taste in the mouth; Immediate hypersensitivity reactions: Urticaria, microangioedema (swelling of the face), fever, erythema; Other side effects: Dizziness, motor and sensory nervous system disturbances, moderate leukopenia (abnormally low white blood cell count) but return to normal on discontinuation of the drug. If you experience any side effects of Flagentyl 500mg, you should tell your doctor right away. From there, the doctor can advise the patient on how to respond and handle appropriately.

4. Be careful when using Flagentyl 500mg

Before and while using Flagentyl 500mg, patients should note:
Flagentyl 500mg contains lactose, so if the patient is intolerant to sugar, it is necessary to inform the doctor before taking the drug; Flagentyl 500mg contains (yellow dye), which may lead to an allergic reaction, especially in patients with a history of reaction to acetylsalicylic acid (aspirin). If the patient has rhinitis, asthma, urticaria and allergy to aspirin, it is advisable to consult a doctor before taking the medicine; Do not drink alcohol while using Flagentyl; Do not use Flagentyl 500mg in patients with a history of hematopoietic disorders, liver disorders, porphyria, diseases of the nervous system; There are insufficient clinical data regarding the effects of Flagentyl 500mg in pregnant women. Therefore, to prevent adverse reactions, it is best not to use Secnidazol for pregnant women; There are no data on the excretion of Secnidazole in human milk. However, other imidazole derivatives are excreted in human milk. Therefore, as a precaution, it is best not to use Flagentyl 500mg in nursing mothers; Very rare cases of dizziness after using Secnidazole. If dizziness is related to medication, the patient should be careful, especially when driving and operating machinery.

5. Flagentyl 500mg . drug interactions

Some drug interactions of Flagentyl 500mg include:
Avoid using Flagentyl 500mg at the same time with alcohol or drugs containing alcohol because it can cause antabuse effect (showing hot flushing, vomiting, pain, lowering severe blood pressure, heart palpitations ); Flagentyl may be used in patients with gluten intolerance. Wheat starch (excipients of the drug) may contain gluten, but only in very small amounts, so it is still considered safe for patients with gluten malabsorption syndrome; Flagentyl should not be combined with disulfiram or used for 2 weeks (used in alcohol detoxification) because it can cause paranoia, confusion, delirium; Caution should be exercised when co-administering Flagentyl 500mg with oral anticoagulants such as warfarin, acenocoumarol because it may increase the effect of anticoagulants and increase the risk of bleeding (due to decreased catabolism in the liver). The prothrombin level should be regularly checked and the INR monitored in the patient. The dose of anticoagulants can be adjusted during treatment with Secnidazol up to 8 days after discontinuation of the drug; Co-administration of Phenobarbital with Flagentyl reduces the effect of Secnidazole by increasing the rate of drug elimination; Concomitant administration of Flagentyl with cimetidine may reduce elimination and increase the risk of overdose; Concomitant use of lithium derivatives with Flagentyl increases the risk of toxicity. Before taking Flagentyl 500mg, patients should honestly tell their doctor about their medical history and any medications they are taking. When using this medication, patients should follow all instructions given to them by their doctor about how to take and how much to take. This helps the patient win the disease, reducing the risk of serious side effects.
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