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Exforge hct is a widely used antihypertensive drug in clinical practice. With the combination of 3 ingredients: Amlodipine, valsartan, hydrochlorothiazide, exforge brings superior effectiveness compared to other antihypertensive drugs with high efficiency, reducing the number of drugs per dose,...1. What is exforge hct?
Exforge hct is manufactured by the manufacturer Novartis Pharma, Switzerland. Exforge hct is a prescription drug, belonging to the list of angiotensin II antagonists, you absolutely must not self-medicate, only use it when prescribed by the treating doctor.Exforge hct is a combination of 3 ingredients Amlodipine, valsartan, hydrochlorothiazide, indicated by doctors in the treatment of essential hypertension and for the prevention of stable angina.
Packing form: film-coated tablets, each containing 160mg valsartan, 5mg amlodipine, 12.5mg hydrochlorothiazide. In each box there are 4 blisters x 7 tablets.
2. Mechanism of action of exforge hct
Exforge hct is a combination of 3 antihypertensive ingredients, so it has a synergistic effect to help lower blood pressure stronger than when using each active ingredient alone.Amlodipine: belongs to the group of calcium antagonists, reduces blood pressure by preventing calcium ions from entering the myocardium and vascular smooth muscle, relaxing vascular smooth muscle, thereby reducing pressure on the vessel wall and lowering blood pressure . Valsartan: Angiotensin II antagonist. Following dosing, plasma angiotensin II concentrations are increased due to the inhibitory effect of valsartan on the AT1 receptor. It therefore has a blood pressure lowering effect without affecting heart rate. The hypotensive effect occurs within 2 hours of dosing and peaks within 4-6 hours, lasting for 24 hours. Hydrochlorothiazide: a thiazide diuretic, the mechanism of action is through inhibition of NaCl transport in the distal convoluted tubule, thereby altering the absorption mechanism of electrolytes, directly reducing the excretion of Na+ and Cl- , which indirectly reduces plasma volume.
3. Uses of exforge hct
Exforge hct is indicated in the following cases:Patients with essential hypertension (Note not to be used for the initial treatment of hypertension) Prophylaxis in patients with stable angina Dose : always carefully read the drug information on the package and follow the doctor's instructions, do not arbitrarily quit, increase or decrease the dose. The correct use of drugs, the right dose will bring high treatment efficiency, reduce blood pressure quickly and cause less unwanted effects. However, if you do not follow the recommendations correctly, there will be unpredictable consequences.
For adults: 1 tablet/day, the dose may be increased after 2 weeks if symptoms have not improved but not exceed 10/320/25mg. No dose adjustment is required for the elderly. For children under 18 years of age: there is no evidence of the effect of this drug on this subject, so it is not recommended. Undesirable effects: some symptoms may occur during use of the drug such as headache, dizziness, dizziness, nervousness, nausea and vomiting, taste disturbances, dry mouth, constipation, ... Immediately contact the treating doctor when there are abnormal symptoms during the drug use for timely treatment or as soon as there are any questions about the use of exforge hct.
What to do in case of overdose or missed dose of exforge hct?
In case of overdose: some symptoms may be experienced when taking an overdose such as increased heart rate, dizziness, low blood pressure, shock and even death. Immediately contact the nearest medical facility for guidance and timely treatment. In case of missed dose: take another dose as soon as you remember. However, if it is close to the time of taking the next dose, skip the missed dose and take the next dose, absolutely do not make up for the dose by taking 2 doses next time.
4. Some notes when using exforge hct
Absolutely do not use exforge hct with the following subjects:Allergic to any ingredient in the drug exforge hct Pregnant women: using this medicine causes the risk of birth defects, spontaneous abortion fetal renal dysfunction. Patients with liver failure, cirrhosis, cholestasis, renal failure. Electrolyte disturbances. Drug interactions: drug interactions can occur due to all 3 components Amlodipine, valsartan, hydrochlorothiazide. Drugs that may interact such as anesthetics, lithium, non-steroidal anti-inflammatory drugs, high protein binding drugs such as coumarin, hydantoin, etc. and inform the treating doctor to make timely changes when taking exforge hct to minimize adverse drug interactions.
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