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Corbis 5mg drug is commonly used in the treatment of high blood pressure and angina attacks with the main ingredient being Bisoprolol fumarate. Let's find out more details about Corbis 5mg drug line through the following article.
1. What is Corbis 5mg?
Corbis 5mg drug belongs to the group of cardiovascular drugs with the use of treating hypertension, angina pectoris.
The drug contains the main ingredient Bisoprolol fumarate 5mg with other excipients including: Dicalcium phosphate, Aerosil 200, Avicel PH-101, Magnesium stearate, Kollidon VA 64, HPMC 2208, talcum powder, Titanium dioxide, Iron oxide yellow, Macrogol 6000, Isopropyl alcohol, lemon yellow, Povidone cross-linked XL, corn starch, purified water.
Corbis 5mg is prepared in the form of film-coated tablets in a box of 2 blisters x 10 tablets.
2. Indications for taking Corbis 5mg
Corbis 5mg drug is indicated for use in the following cases:
Mild to moderate hypertension. May be used as monotherapy or in combination with other antihypertensive agents, especially diuretics. Treatment of angina pectoris. Support and treatment of stable chronic heart failure. In combination with other drugs such as ACE inhibitors, diuretics, cardiac glycosides for the treatment of moderate to severe chronic heart failure with decreased left ventricular systolic function.
3. Dosage and how to use Corbis 5mg
Corbis 5mg is used orally. Specific dosage is determined according to each patient in accordance with heart rate and treatment results.
Treatment of high blood pressure and angina in adults:
Usual dose: Take a single dose of 5 - 10 mg of Bisoprolol/day. Maximum dose: 20 mg Bisoprolol/day. Use only once a day. In the case of patients with mild to moderate hepatic and renal dysfunction, it is not necessary to adjust the dose of Bisoprolol, the recommended initial dose is 2.5 mg of Bisoprolol/day and the dose should be adjusted accordingly. The dose should not exceed 10 mg of Bisoprolol/day in patients with severe renal impairment (creatinine clearance < 20 ml/min) or severe hepatic dysfunction. Treatment of heart failure:
Patients with chronic heart failure must be stable, have no exacerbations within 6 weeks, and are being treated with an ACE inhibitor at an appropriate dose and a diuretic before starting treatment. treatment with Bisoprolol. During the last 2 weeks before taking the drug, the dose of Bisoprolol fumarate should not be changed.
Treatment of stable chronic heart failure with Corbis 5mg drug must start with a dose adjustment period, the dose is gradually increased according to the following scheme:
Use a dose of 1.25 mg Bisoprolol/1 time/day (taken in the morning) morning) for 1 week. If well tolerated, the dose can be increased. Dose of 2.5 mg Bisoprolol 1 time / day for 1 week. If well tolerated, the dose can be increased. Use a dose of 5mg Bisoprolol once a day for the next 4 weeks. If well tolerated, the dose can be increased. Use a dose of 7.5 mg Bisoprolol 1 time / day for the next 4 weeks. If well tolerated, the dose can be increased. Use a maintenance dose of 10 mg Bisoprolol once a day. After starting the first dose of 1.25 mg Bisoprolol, it is necessary to monitor the patient's blood pressure, conduction disturbances, signs of worsening heart failure, injection frequency within 4 hours. The maximum recommended dose is 10 mg of Bisoprolol once a day. Treatment of stable chronic heart failure with Corbis 5mg is a long-term treatment, absolutely do not stop suddenly because it can worsen heart failure. If discontinuation of the drug is necessary, the dose should be gradually reduced and the dose divided in half weekly. Elderly:
No dose adjustment of Bisoprolol is required. Children:
There are no specific data, however, the use of Bisoprolol in children is not recommended. In case of overdose:
In the case of an overdose of Corbis 5mg, the patient will experience unusual symptoms such as bradycardia and hypotension. At this time, the patient needs to stop using Corbis immediately and treat with intravenous atropine from 1 to 2 mg, in case of need, 1 intravenous dose of 25 mcg isoprenaline can also be used, glucagon can also be used with a dose of 1 to 1. 5 mg. Bronchospasm and heart failure may occur. Treatment of heart failure with cardiovascular drugs - Digitalis with diuretics or bronchospasm by intravenous injection of Aminophylline.
4. Contraindications to taking Corbis 5mg
Corbis 5mg drug is not used in the following cases:
Patients with a history of allergy, hypersensitivity to Bisoprolol, beta blockers or any other ingredient of the drug. Cardiogenic shock, acute heart failure, uncontrolled heart failure, grade III and IV heart failure, sinus bradycardia below 60/min before drug therapy. Sinus node disorder syndrome Sinus atrial block. Bradycardia <50 beats/min was measured at the start of treatment. Typical low blood pressure is a systolic blood pressure < 90 mmHg. Metabolic acidosis. Bronchitis, Bronchial asthma, chronic respiratory diseases. The patient is taking MAO inhibitors to treat Peripheral Circulatory Disorders in the advanced stage. Raynaud's syndrome can cause an itchy or pale, blue discoloration. Note:
Patients with adrenal tumors or pheochromocytoma, Corbis 5mg can only be used after blockers. Precautions for patients with diabetes, patients with metabolic acidosis, long-term starvation with sharp fluctuations in glycemic index, first-degree atrioventricular block and Prinzmetal angina. In patients with a history of psoriasis or a family with psoriasis, use Corbis 5mg only after carefully weighing the benefits against the risks.
5. Corbis 5mg drug interactions
When combined with Corbis 5mg with some of the following drugs, drug interactions may occur:
Drugs used to treat cardiac arrhythmias: Quinidine, Disopyramide, Lidocaine, Phenytoin, Flecainide, Propafenone, Amiodarone,... Medicines to treat high blood pressure, angina and irregular heartbeat: Verapamil, Diltiazem (calcium channel blocker),... High blood pressure medicine: Clonidine, Rilmenidine, Methyldopa, Moxonidine,... Timolol eye drops or glaucoma medications such as tacrine or carbachol. Diabetes medication. Anesthetic agents during surgery. Mefloquine for the prevention and treatment of malaria MAOIs such as moclobemide. Ergotamine is used in the symptomatic treatment of migraine...
6. Side effects when taking Corbis 5mg
In the process of taking Corbis 5mg, patients may experience some unwanted side effects such as:
Fatigue, sweating, dizziness, dizziness, headache, anxiety, sleep disturbances, These symptoms are usually less severe and will go away 1 to 2 weeks after starting treatment. Digestive disorders (nausea, vomiting, diarrhea, constipation, abdominal pain, stomach, epigastric pain, peptic ulcer,...) Hypotension, atrioventricular conduction disturbances, bradycardia . Numbness and coldness in the extremities. Skin reactions (swelling, erythema, itching, hair loss...) Myasthenia gravis, Raynaud's phenomenon, limping gait. Elderly people with diabetes when taking the drug may mask symptoms such as low blood sugar, tachycardia.
7. Precautions when using Corbis 5mg
The following cases need to be cautious when using Corbis 5mg for treatment:
Patients with congestive heart failure should not use beta-blockers. However, if it is necessary to use Corbis, it must be very cautious. Do not discontinue the drug abruptly because beta-blockers may worsen myocardial infarction, angina, or ventricular arrhythmias in patients with coronary artery disease. The patient has bronchospasm. People preparing for surgery and anesthesia: Corbis should be discontinued at least 48 hours before the patient undergoes surgery. If drugs must be used during surgery, caution should be exercised with anesthetic agents such as Cyclopropan, Ether, Trichlorethylene. Patients with diabetes and hypoglycemia: Bisoprolol mask the manifestations of hypoglycemia (especially tachycardia). However, in diabetics for whom insulin or oral hypoglycemic agents are prescribed, Bisoprolol should be used with caution. Thyroid toxicity: Bisoprolol may mask clinical signs of hyperthyroidism (such as tachycardia). Abrupt discontinuation of Bisoprolol may precipitate a bout of thyrotoxicosis. Corbis 5mg should not be used by women who are pregnant or breastfeeding. Because the drug has a side effect of lowering blood pressure, depending on the patient, it may affect the ability to drive and use machines. This condition is common at the beginning of treatment, in combination with alcohol, or with a change in medication. Use caution with people who are on a strict vegetarian diet. History of psoriasis.
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