Uses of Cobifen

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1. Uses of Cobifen

Cobifen drug whose main ingredient is paracetamol (acetaminophen or N-acetyl-p-aminophenol) is a non-steroidal anti-pyretic analgesic. Paracetamol is an active metabolite of phenacetin, an effective analgesic and antipyretic that can replace aspirin, but paracetamol is not effective in the treatment of inflammation. At equal doses, paracetamol has analgesic and antipyretic effects similar to aspirin.
In addition, paracetamol with therapeutic doses has little impact on cardiovascular and respiratory systems, does not change acid-base balance, does not cause irritation, scratches or stomach bleeding as when taking salicylates, because paracetamol does not affect It acts on systemic cyclooxygenase, acting only on central nervous system prostaglandins. Paracetamol has no effect on platelets or bleeding time.

2. Indications and contraindications of Cobifen

Cobifen is often indicated to treat pain, fever, and strengthen the body's resistance:
Headaches caused by colds, flu Musculoskeletal pain, sprains Upper respiratory tract infections: earache, sore throat, sinusitis caused by infection or weather Patients after tonsillectomy, tooth extraction, teething, toothache Contraindications of Cobifen include:
Patients with hypersensitivity reactions to Cobifen. Paracetamol Cases of glucose-6-phosphate dehydrogenase deficiency Patients with impaired liver function, history of kidney stones Oxalate metabolism disorders Thalassemia patients with anemia many times

2. Dosage of Cobifen

Cobifen drug is prepared in powder form when used, dissolving the drug in the appropriate amount of water to drink. Dosage of Cobifen depends on the subjects and treatment goals, specifically as follows:
Adults and children over 15 years old: 2 packs x 3 times/day Children from 6-15 years old: 1-2 pack x 3 times/day Children from 2 to 6 years old: 1 pack to drink morning, noon, and afternoon Every 6 hours, no more than 5 times/day Total maximum dose not more than 60 mg/kg body weight/ 24 hours

3. Side effects of the drug Cobifen

In some patients when using Cobifen, side effects may occur such as:
Allergic reactions Liver failure due to hepatocellular destruction when used in high doses, for a long time Vitamin C is usually well tolerated, so high doses should be used. May cause diarrhea, other digestive disorders and hemolytic symptoms in people with G6PD deficiency. Overdose of vitamin C can cause uricuria, stones due to oxalate accumulation in the kidneys.

4. Be careful when using Cobifen

Some general notes when using Cobifen include:
Cobifen should not be shared with other drugs containing paracetamol Limit alcohol during the use of Cobifen Currently, the safety of paracetamol has not been determined. For pregnant women should use only when absolutely necessary and weigh the benefits and risks. Paracetamol has not shown any adverse effects in nursing infants Cobifen does not affect the ability to drive and use machine

5. Cobifen drug interactions

Common drug interactions of Cobifen include:
Co-administration of Cobifen with anticoagulants (warfarin) slightly increases the effect of anticoagulants Vitamin C is a strong reducing agent, so it may affect the results of these drugs. biological test Taking high doses of ascorbic acid (vitamin C) can destroy vitamin B12, so when used in high doses within 1 hour before or after taking vitamin B12 Concomitant use of ascorbic acid with fluphenazine leads to a decrease in fluphenazine concentrations plasma Alcohol, anticonvulsants, isoniazid will increase the risk of paracetamol toxicity to the liver. Cobifen is a non-steroidal anti-inflammatory drug with the main ingredient of acetaminophen and vitamin C. It is a non-steroidal anti-inflammatory drug that is commonly used to treat symptoms of pain or fever due to various causes. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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