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Parkinson's disease is a chronic progressive degenerative disease, common in the elderly due to many different causes. Currently, there are many groups of drugs to treat Parkinson's, including the active ingredient Rasagiline present in the drug product Azilect 1 mg.1. What is Azilect 1 mg?
Azilect medicine 1mg contains the active ingredient Rasagiline with the main effect of stimulating an increase in the concentration of some neurotransmitters in the brain.
Azilect 1 mg product is mainly used to treat symptoms of Parkinson's disease, including muscle stiffness, tremors, abnormal muscle contractions or difficulty controlling muscles... Parkinson's patients can use Azilect drug. as monotherapy or in combination with Levodopa.
2. Some cautions of the drug Azilect 1 mg
Patients should not use Azilect if they have used MAO inhibitors within the previous 14 days, such as Isocarboxazid, Linezolid, methylene blue, Phenelzine, Selegiline or Tranylcypromine. Therefore, patients should talk to their doctor about all products used within a 2-week period before starting treatment with Azilect 1 mg. Many active ingredients can interact with Rasagiline, some of which should not be used at the same time.
While using Azilect and for at least 2 weeks after stopping treatment, you may not be allowed to consume certain types of cheese. Rasagiline can impair a user's thinking or reactions, so special care should be taken if the patient has to drive or do work that requires alertness.
Some problems patients need to inform their doctor before taking Azilect 1 mg:
Do not use Azilect if you have a history of being allergic to Rasagiline; Do not use Azilect if you have used an MAO inhibitor product within the previous 14 days because of possible dangerous drug interactions; Many drugs can interact with Azilect and lead to dangerous effects, especially those that must not be used at the same time as Azilect 1 mg. Such drugs include Cyclobenzaprine (a muscle relaxant), Dextromethorphan (over-the-counter cough medicine), Meperidine, Methadone, Tramadol; Patients should be sure not to take stimulants, opioids, herbs or medications for depression, mental illness, migraines, infections, or antiemetics. The above products can interact with Rasagiline and lead to very serious serotonin syndrome. To ensure the safety of the use of Azilect, the patient should inform the doctor about the following:
Increase or decrease in blood pressure; Liver or kidney disease; Currently taking the antibiotic Ciprofloxacin. The potential for fetal harm with Azilect 1 mg is unknown. Therefore, female patients should tell their treating doctor if they are pregnant or plan to become pregnant. In addition, Azilect may not be safe for women who are breastfeeding, so patients should talk to their doctor about the possible risks.
3. Instructions for using Azilect 1 mg
Patients need to use Azilect exactly as prescribed by the doctor, and at the same time follow the instructions on the package or the accompanying leaflet. Note that Azilect as monotherapy will have a different dose than when combined with other Parkinson's drugs.
Azilect 1 mg is only part of a complete Parkinson's therapy, in addition to special dietary changes. Therefore, people with Parkinson's need to follow a suitable diet as directed by a doctor or nutritionist. In addition, there are certain foods that the patient should avoid to prevent the side effects of Rasagiline.
During treatment with Azilect , patients can contact their doctor when Parkinson's symptoms do not improve or tend to get worse. Never stop using Azilect suddenly because of the risk of withdrawal symptoms. Your doctor will give you instructions on how to reduce your dose before stopping the medication completely.
The recommended dose of Azilect for adults with Parkinson's disease is as follows:
Monotherapy: The recommended dose is Azilect 1 mg 1 tablet taken once daily; Supportive treatment: Initial dose (in patients taking Levodopa concomitantly): 0.5 mg orally once a day; Initial dose (in patients not taking concomitant levodopa): Azilect 1 mg orally once a day; Maintenance dose: 0.5 to 1 mg orally once a day; Recommendations: Azilect can be used as adjunctive therapy in Parkinson's patients on levodopa therapy, with or without other drugs. The maximum daily dose of Azilect is 1mg, in case of overdose, there may be signs such as drowsiness, dizziness, severe headache, rapid pulse, agitation or irritability, muscle spasms in the neck or jaw, sweating, cold or rough skin, shallow breathing, fainting or convulsions. Note that overdose symptoms may appear within 12 to 24 hours after taking the drug.
4. Some problems to avoid when taking Azilect
Avoid the use of alcohol, especially red wine, vermouth and beers during the use of Azilect 1 mg; Avoid consuming foods high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats and fish, and meats that have been aged, dried, smoked or fermented . Tyramine supplements while taking Azilect can cause dangerously high blood pressure and lead to life-threatening risks.
5. Side effects of Azilect
Contact the treating doctor immediately if the person with Parkinson's disease takes Azilect and has the following symptoms:
Severe headache, blurred vision, pounding pulse in the neck or ears; Severe drowsiness or sudden onset of sleep even when you feel awake; Mood swings or unusual behavior; The appearance of hallucinations; Feeling about to faint; Parkinson's symptoms worsen, especially uncontrolled myoclonus. Some people taking the combination of Azilect 1 mg and Levodopa experience severe drowsiness even during daytime activities such as working, talking, eating, or driving. Notify your doctor if you experience daytime sleepiness. Users of Azilect may experience increased sex drive, abnormal desire to gamble, or other intense desires.
Some common side effects of Azilect:
Depressed mood; Sleep disturbances, strange dreams; Involuntary motor movements; Anorexia, weight loss; Eating indigestion, stomach pain, nausea, vomiting, constipation; Stiffness pain; Cough or other flu-like symptoms; Dry mouth ; Swollen hands or feet.
6. Drug interactions of Azilect 1 mg
Using Azilect with other sedatives may worsen the side effects of drowsiness. Medications to watch out for are opioids, tranquilizers, muscle relaxants, or anti-anxiety or anticonvulsant medications. In particular, patients need to inform their doctor if the time 2 weeks before starting Azilect drug is used with antidepressant drugs.
Many drugs can interact with Rasagiline, some of which should not be combined at the same time. Therefore, patients should talk to their treating physician about all medications they are taking, including prescription and nonprescription drugs, vitamin supplements, and herbs.
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