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With three main ingredients, efavirenz, emtricitabine and tenofovir disoproxil, which have antiviral effects, Atripla is prescribed for adult patients infected with human immunodeficiency virus type 1 (HIV- first). Join us to learn the necessary information about the use of Atripla drug through the article below.
1. The effect of the drug Atripla
Atripla is a medicine that contains three active ingredients: efavirenz 600mg, emtricitabine 200mg and tenofovir disoproxil 245mg.
Atripla is an antiviral medicine used to treat adult patients infected with the human immunodeficiency virus type 1 HIV-1, which is a virus of the immunodeficiency syndrome. AIDS epidemic.
Atripla should only be given to patients who have had an HIV blood level (viral load) of less than 50 copies per ml for more than three months with current combination anti-HIV therapy.
Atripla should not be used in patients who have failed previous antiretroviral therapy or it is necessary to exclude that the patient has HIV before initiating the first antiretroviral therapy because there is a low likelihood of response. even with one of the three active ingredients in Atripla.
This medicine can only be obtained by prescription from a specialist.
Treatment with Atripla must be started by a physician experienced in the control of HIV infection. The recommended dose for patients is one tablet per day. Atripla should be taken on an empty stomach, preferably at bedtime. Take medicine regularly to avoid missing doses.
In the elderly use caution when taking Atripla as it is not recommended for use in patients with mild to severe kidney problems. Patients with liver problems must be closely monitored for unwanted side effects.
If the patient has to stop taking efavirenz, emtricitabine or tenofovir disoproxil or the dose is changed, drugs containing efavirenz, emtricitabine or tenofovir disoproxil should be administered separately. Atripla must not be taken with other medicines containing efavirenz, emtricitabine, tenofovir disoproxil, or lamivudine (another antiviral medicine).
2. How to use Atripla
2.1. You should not take Atripla if you are allergic to efavirenz (Sustiva), emtricitabine (Emtriva) or tenofovir (Viread).
Do not take Atripla with medicines: adefovir, atazanavir, voriconazole or any medicine containing emtricitabine, lamivudine or tenofovir
To make sure Atripla is safe, tell your doctor if you have: kidney disease or liver disease, long QT syndrome, mental illness, use of antipsychotic drugs, or are taking injectable drugs, other seizure disorder or epilepsy, low bone mineral density, hepatitis B or hepatitis C infection.
Patients may develop lactic acidosis, a dangerous buildup of lactic acid in the blood. This may be more likely if you have other medical conditions, if you have been taking HIV medicines for a long time, or if you are a woman. Ask your doctor about the patient's risk.
Efavirenz, emtricitabine and tenofovir can cause birth defects. Do not use Atripla if you are pregnant and should not become pregnant for at least 12 weeks after you stop taking it.
Atripla may make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings). Use two forms of birth control (condom or diaphragm with spermicide) to prevent pregnancy.
Women with HIV or AIDS should not breastfeed. Even if a baby is born without HIV, the virus can be passed to the baby in breast milk.
2.2. How should I use Atripla? Take Atripla exactly as prescribed by your doctor. Follow all directions on your medication label and read all medication instructions or instruction sheets.
Take this medicine on an empty stomach with a full glass of water.
The patient will need to have regular medical tests.
This drug affects urine tests, when sieved, there may be false results. Tell laboratory staff that the patient is taking efavirenz, emtricitabine, and tenofovir.
If the person has had hepatitis B in the past, the virus may worsen in the months after the person stops taking Atripla. Regular liver function tests may be necessary while the patient is taking this medicine and for several months after the last dose.
What happens if a dose is missed?
Take the medicine as soon as possible, but skip the missed dose if it is almost time for the next dose. Do not take two doses at the same time.
What happens if overdose?
Seek emergency medical attention or call 911. Overdose symptoms may include uncontrolled muscle movements.
What should be avoided while taking Atripla?
Avoid driving or dangerous activities until you know how this medicine will affect you. Your response may be impaired.
Using this medicine will not prevent your disease from spreading. No unprotected sex or sharing razors or toothbrushes. Talk to your doctor about safe ways to prevent HIV transmission during sex. Sharing drugs or needles is never safe, even for healthy people.
2.3. Atripla Dosage Information Usual Adult Dose of Atripla for HIV Infection:
1 tablet taken once daily Use this medication as a complete regimen or in combination with other antiretroviral agents for the treatment of HIV infection. HIV-1 Usual Adult Dose of Atripla for Inexperienced Persons:
US CDC Recommendations: 1 tablet taken once daily Duration of treatment is 28 days
Usual Adult Dose of Atripla for occupational exposure:
US Public Health Service working group recommendation: 1 tablet taken once daily Duration of treatment: 28 days, if tolerated
Usual Pediatric Dose for Infection HIV:
12 years and older weighing at least 40kg: 1 tablet taken once a day
Use: As a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection
3. Contraindications of Atripla
Do not take medicine at the same time because sometimes it will not be safe. Some medicines can affect the blood levels of the drug, which can increase side effects or make the medicine less effective.
Atripla can harm your kidneys, especially if certain medicines are used to treat infections, cancer, osteoporosis, organ transplant rejection, intestinal disorders, or pain or arthritis.
Talk to your doctor about all the medications you are taking. Many drugs can interact with efavirenz, emtricitabine and tenofovir, especially:
An antibiotic or antifungal medicine; Antidepressants; Any other HIV medicine; cholesterol-lowering drugs; Medicines to treat heart disease or blood pressure; Medicines to prevent organ rejection; Medicines for hepatitis; Epilepsy drugs; or medicine for tuberculosis. There are several other drugs not listed here. There are many drugs that can interact with efavirenz, emtricitabine and tenofovir and some drugs should not be used at the same time. Tell your doctor about all current medications and any medications you start or have just stopped using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
4. Notes when using the drug Atripla
Do not take Atripla together with adefovir, atazanavir, voriconazole or medicines containing emtricitabine, lamivudine or tenofovir.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Atripla can cause serious or fatal liver problems. Call your doctor at once if you have symptoms such as stomach pain or swelling, loss of appetite, dark urine, or yellowing of the skin or eyes.
Atripla can cause a serious condition called lactic acidosis, a dangerous buildup of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
If you have ever had hepatitis B, it may become active or get worse after you stop using Atripla. You may need regular liver function tests for several months.
5. Side effects of the drug Atripla
Get medical attention, or call a doctor urgently if you have signs of a reaction to Atripla, such as hives, difficulty breathing, swelling of your face or throat, or a severe skin reaction. such as: fever, sore throat, burning eyes, skin pain, red or purple skin rash that blisters and peels.
Mild symptoms of lactic acidosis may worsen over time and the condition can be fatal. Call your doctor at once if: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heartbeat, dizziness, feeling cold, or feeling very weak or tired.
Call a doctor right away if the person has:
Unusual thoughts or behavior, anger, severe depression, thoughts of hurting yourself or others, hallucinations Seizures Thirst and urination much, muscle pain or weakness. Liver problems such as: right-sided stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Atripla affects your immune system, which may cause certain side effects (even weeks or months after you take this medicine). Tell your doctor if you have:
New signs of infection – fever, night sweats, swollen glands, sores, cough, wheezing, diarrhea, weight loss; Difficulty speaking or swallowing, problems with balance or eye movement, weakness or stinging sensation; either Swelling in the neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects of Atripla may include: dizziness, drowsiness, feeling tired, nausea, diarrhea, headache, depressed mood, trouble concentrating, sleep problems (insomnia). , strange dreams, rash; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, chest, and waist).
The above is not a complete list of side effects and others that may occur. There are any effects or abnormalities of the body can contact the doctor for guidance and care.
6. How to store Atripla
Remember, always keep medicine out of reach of children. Do not share your medication with anyone else. Use Atripla only when prescribed by your doctor. Carefully read the instructions for storage information on the package and the instruction sheet for Atripla 600; 200; 300mg/1; mg/1; mg/1. Check the drug's expiry date before use When not in use, the medicine should be collected and disposed of according to the instructions of the manufacturer or the person in charge of medicine. Conventional drugs are stored at room temperature, avoiding direct sunlight or high temperature to avoid metabolizing the ingredients in the drug. Store Atripla in its original container, away from moisture, heat and light. Hold the bottle tightly when not in use.
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