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CombiPatch contains 2 types of female sex hormones, used to relieve symptoms in menopause or patients who do not produce enough estrogen. Follow the article below to know what is Combipatch?1. What is Combipatch?
CombiPatch contains 2 types of female hormones: an estrogen (estradiol) and a progestin (norethindrone). It is used to help relieve symptoms of menopause such as hot flashes and vaginal dryness.The above symptoms are caused by the body producing less estrogen. In addition, the Progestin component in CombiPatch also helps reduce the risk of uterine cancer due to estrogen use. Women who have had a hysterectomy do not need a progestin. CombiPatch may also be used in women who cannot produce enough estrogen, such as those with hypogonadism and primary ovarian failure.
2. Usage and dosage of Combipatch
2.1 Directions Patients must use CombiPatch exactly as directed by their doctor. Do not use more, more often, and do not use it for a longer time than prescribed by your doctor because it may increase unwanted side effects. Before starting CombiPatch therapy, patients may need to let their doctor know if they are currently using either continuous estrogen or estrogen-progestin combination therapy. This will allow your doctor to determine when to start treatment. The patch will be applied to the lower abdomen twice a week, depending on the patient's dosing regimen (continuous combination regimen or sequential sequential regimen). To use the patient skin patch perform the following steps:
Wash hands with soap before and after applying CombiPatch. Peel the backing off the patch and apply the patch to a clean, dry, hair-free lower abdomen. The area must be free of oil or lotion for the patch to adhere to the skin. Press the patch firmly against the skin with your hand for about 10 seconds. Do not stick the patch on the breast or on any skin folds. Do not apply the patch on oily, cracked, burned or irritated skin or on areas with skin conditions (such as stretch marks, tattoos). Avoid applying CombiPatch to the waistline or other places where tight clothing can rub. When changing the CombiPatch patch, slowly peel the patch off the skin. If any patch remains on the skin, let it dry for 15 minutes and gently rub the affected area with oil or lotion to remove. It's best to change the patch on the same days of the week to make it easier to remember. When changing the patch, be sure to apply the new patch to a different area of the lower abdomen. Patients should wait at least 1 week before applying the patch to the same area of skin. If 1 patch falls off, just put it back in another location. To dispose of a used patch: Fold the adhesive side patch in half and place it in a sturdy box. Throw the container in the trash, away from children and pets. Do not throw the patch down the toilet. 2.2 Dosage The dosage of CombiPatch will be different for different patients. Patients should follow the doctor's prescription or the directions on the label. The following information includes only the average doses of the drug for the treatment of hot flashes, atrophic vaginitis due to menopause:
Continuous combination regimen:
Adults: Take 1 CombiPatch pad twice a week (3 times a week) up to every 4 days) in a 28-day cycle. One CombiPatch patch contains 0.05 milligrams of estradiol and 0.14 or 0.25 mg of norethindrone. Children: Not recommended for use. Continuous sequential regimen:
Adults: Apply the 0.05-milligram (mg) estradiol patch (Vivelle-Dot) twice a week (every 3 to 4 days) for the first 14 days of a 28-day cycle. Then, take CombiPatch twice a week (every 3 to 4 days) for the next 14 days of a 28-day cycle. One CombiPatch patch contains 0.05 milligrams of estradiol and 0.14 or 0.25 mg of norethindrone. Children: Not recommended for use.
3. What are the side effects of CombiPatch?
CombiPatch can cause some unwanted effects including:
Common:
Swelling or swelling of the face, arms, hands, legs or feet; Vaginal bleeding, irregular periods; Vaginal or genital itching; Pain during sex ; Rapid weight gain; Vaginal discharge that is thick, white, odorless or has a slight odor; Tingling of the hands or feet; Unusual weight gain or loss. Uncommon:
Cough or hoarseness ; Fever or chills; Lower back pain or pain on one side; Painful or difficult urination; Bloating, stomach upset or stomach pain; Blurred vision; Change in vaginal discharge; Clay colored stools; Clear or bloody discharge from the nipple, indented breast skin; Dark urine; Diarrhea, bad breath; Dizziness, headache, intense and sharp pain. If you experience these symptoms, you need to stop using CombiPatch and notify your doctor for appropriate treatment.
4. What are the precautions when using CombiPatch?
Using CombiPatch while you are pregnant can harm your unborn baby. If the patient becomes pregnant while using the drug, tell your doctor immediately. Using CombiPatch may increase your risk of blood clots, stroke, or heart attack. This risk can continue even after stopping the drug. The risk of these serious problems is even higher if the patient has high blood pressure, high cholesterol, diabetes, is overweight or smokes. Contact a physician immediately if patient experiences chest pain, confusion, difficulty speaking, double vision, headache, inability to move arms, legs, facial muscles, or inability to speak. Using CombiPatch may increase your risk of endometrial cancer, breast cancer, or cancer of the uterus. Check with your doctor immediately if you have unusual vaginal bleeding. Do not use CombiPatch if the patient has had a hysterectomy. Using this medicine may increase the risk of dementia, especially in women 65 years of age and older. Check with your doctor right away if a severe headache or sudden loss of vision or any other change in vision occurs while you are using CombiPatch. CombiPatch can cause serious types of allergic reactions, including life-threatening anaphylaxis. Call your doctor at once if you have a rash, itching, hoarseness, dizziness or lightheadedness, trouble breathing, trouble swallowing, or any swelling in your hands, face, or mouth while taking the medicine. Patients may need to stop using CombiPatch before surgery or if they need to stay in bed for a long time. Medicines can also affect the results of some medical tests. Do not eat grapefruit or drink grapefruit juice while you are taking this medicine because it can change how much medicine is absorbed into your body. Elderly patients are more likely to develop breast cancer, stroke or dementia. Therefore, patients may need to exercise caution when taking CombiPatch. Lactation: There are no adequate studies to determine the risk in the infant when this medicine is used during breast-feeding. Weigh the potential benefits against the possible risks before taking CombiPatch while breastfeeding. Storage: Store the patch at room temperature in an airtight container, away from heat, moisture and direct light, out of reach of children. Store unopened CombiPatch packs at room temperature for up to 6 months. Do not store the patch outside the carrying case. Drug Interactions: Some products that may interact with CombiPatch include aromatase inhibitors (such as Anastrozole, Exemestane, Letrozole), Fulvestrant, Ospemifene, Raloxifene, Tamoxifen, and Tranexamic acid. It is best for the patient to inform the doctor of all the drugs and supplements they are using for advice. Above is an overview of the drug CombiPatch. Patients should consult a specialist before using the drug to ensure maximum effectiveness.
References: webmd.com
