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Sirolimus Protein-Bound is a prescription drug used in the treatment of cancer. So what is Sirolimus Protein-Bound, and how does it work?
1. What is Sirolimus Protein-Bound?
Sirolimus Protein-Bound is a Kinase inhibitor/mTOR inhibitor.
Sirolimus binds to a protein that is an inhibitor of the kinase, rapamycin kinase (mTOR kinase), an enzyme essential for cell growth and survival.
By blocking this enzyme, Sirolimus Protein-Bound drug stops cell division and tumor growth. The drug can also disrupt the formation and growth of blood vessels that supply nutrients to tumors so they can grow.
2. How to use Sirolimus Protein-Bound
Sirolimus Protein-Bound is used intravenously. The dose of the drug is calculated by the doctor based on the patient's body size. How often you receive Sirolimus Protein-Bounds will be determined by your doctor.
Sirolimus Protein-Bounds blood levels can be affected by certain foods and medications, so they should be avoided, including: Grapefruit, grapefruit juice, verapamil, ketoconazole, rifampin, phenytoin, St. John's wort, and modafinil, some other medicines. Be sure to tell your doctor about all medications and supplements.
The use of live attenuated vaccines should be avoided while receiving Sirolimus Protein-Bounds. These include the herpes zoster vaccine (Zostavax) to prevent shingles, the oral polio vaccine, measles, the nasal flu vaccine (FluMist®), the rotavirus vaccine, and the flu vaccine. yellow fever.
3. Possible side effects of Sirolimus Protein-Bound
The most common or important side effects of Sirolimus Protein-Bounds include:
Mouth ulcers (Mucositis): Some cancer treatments can cause sores or sores in the mouth. Notify your doctor if your mouth, tongue, inside of your cheeks or throat becomes white, sore, or painful. Performing oral care regularly can help prevent or control canker sores. If mouth sores become painful, your doctor or nurse may recommend pain medication. Anemia: Red blood cells are responsible for carrying oxygen to the tissues in the body. When your red blood cell count is low, you may feel tired or weak. At this point, tell your doctor if you feel short of breath or have chest pain. If your red blood cell count is too low, you may receive a blood transfusion. Kidney problems: Sirolimus Protein-Bound can cause kidney problems, including increased creatinine. Your doctor can monitor using blood tests. Notify your doctor if you notice decreased urine output, blood in your urine, swollen ankles, or loss of appetite. Fatigue: Fatigue is very common during cancer treatment and is a feeling of exhaustion that doesn't go away with rest. During cancer treatment and for a while afterward, you may need to adjust your activity schedule to control fatigue. Plan time to rest during the day and save energy for more important activities. Exercise can help fight fatigue; A daily walk with a friend can help relieve fatigue. Talk to your doctor for helpful tips on how to deal with this medication side effect.
Rash: Some patients may develop a rash, scaly skin, or an itchy red rash. Use an alcohol-free moisturizer on your skin to reduce skin rashes. Infections and low white blood cell counts: Sirolimus Protein-Bound can cause life-threatening infections, with or without lowering white blood cell counts. White blood cells (WBCs) are important for fighting infections. While being treated with Sirolimus Protein-Bounds, your white blood cell count may drop, putting you at higher risk of infection. You should notify your doctor or nurse immediately if you have a fever (temperature higher than 38°C), sore throat or cold, trouble breathing, cough, burning when urinating, or pain that does not heal. High Cholesterol/Triglyceride Levels: Sirolimus Protein-Bound may cause high cholesterol or triglycerides. You can be monitored for this with a blood test. There are no immediate symptoms when cholesterol/triglycerides are high but when not treated appropriately can lead to heart attack and stroke. Nausea or vomiting: Talk to your doctor to prescribe medication to help you control nausea and vomiting. In addition, dietary changes may be helpful. Avoid foods that are greasy, spicy or acidic (lemon, tomato, orange). Call your doctor if you feel light-headed or dizzy at any time. Diarrhea: Diarrhea can be a serious side effect of Sirolimus Protein-Bound. Notify your doctor if you begin to have diarrhea to determine which medication you should take. Diarrhea can lead to dehydration so it is important to control this side effect. In addition, there are a few other side effects that can be mentioned such as: muscle pain, headache, high blood pressure, constipation.... If these side effects are prolonged, affecting the patient's health, they should be given. Talk to your doctor for more appropriate instructions.
4. Effect of Sirolimus Protein-Bound on sex and reproduction
Sirolimus Protein-Bound may affect the reproductive system resulting in menstrual cycles or sperm production becoming irregular or permanently stopped. Women may experience menopausal effects, including hot flashes and vaginal dryness. In addition, libido may decrease during treatment with Sirolimus Protein-Bounds.
You may want to consider using a sperm bank or egg harvesting if you want to have children in the future. Discuss these options with your oncologist.
Exposure of the unborn baby to Sirolimus Protein-Bound can cause birth defects, so you should not become pregnant or father a child while using this medicine. Effective birth control is necessary during treatment and for at least 12 weeks after treatment with Sirolimus Protein-Bounds, even if your periods have stopped or you believe you are not fertile. more sperm.
You should not breastfeed while taking Sirolimus Protein-Bounds or for 2 weeks after your last dose.
Hope with the above important information to help customers understand more about how to use Sirolimus Protein-Bound medicine to get the most positive effects on the patient's health.
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