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Odomzo medicine contains the active ingredient sonidegib with a strength of 200mg, which is made in the form of tablets. The drug is indicated in the treatment of basal cell carcinoma. However, when using Odomzo, there may be some unwanted side effects such as muscle pain, muscle tension, rash, difficulty breathing...
1. Mechanism of action of the drug Odomzo
Odomzo contains the ingredient Sonidegib which is known to inhibit the transmembrane protein SMO. At the same time, this active substance has a role in Hh signaling. It then induces inhibition of Hh signaling as well as antitoxic activity in different isoform models.
In a genetically engineered mouse model of peach cell tumours, tumor volume was reduced by up to 95% in Odomzo-treated mice when compared to untreated mice.
2. Indications and contraindications of the drug Odomzo
What is Odomzo? Odomzo is a prescription medication used in the treatment of adults with basal cell carcinoma, skin cancer, or cancer that has recurred after surgery/radiation, or possibly untreated disease. by surgery as well as radiation.
Medicines can be prescribed for some other cases and need to be followed by the doctor's prescription. However, Odomzo is also contraindicated for some cases such as: patients with muscle spasms or a history of muscle disorders, rhabdomyolysis, or pregnant and lactating women.
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3. Dosage and how to use Odomzo
Odomzo drug is recommended for the treatment of basal cell carcinoma - skin cancer with a dosage of 200mg each time and used for one day. Odomzo is made in tablet form, so it can be taken with water and should be taken on an empty stomach. In case of taking after a meal, the patient should take it at least 1 or 2 hours after eating to ensure that the stomach is still empty. Odomzo tablets should be swallowed whole and should not be broken or chewed, as this may reduce the effectiveness of the drug. Patients should pay attention to the dosage of the drug to use the correct and complete dose as prescribed. Some drugs include modafinil, nafcillin, phenytoin, phenobarbital, azole antifungals, or some antiretroviral therapy. It should be noted: The above recommended therapeutic doses for Nexavar are for reference only. Therefore, before using Nexavar, patients need to be prescribed by a doctor.
If the patient has missed a dose of Odomzo, take the missed dose as soon as you remember. However, if the interval between the missed dose of Odomzo and the next dose is close, the patient can skip the missed dose and take the next dose. It should be noted that a double dose of Odomzo should not be used, because it may cause an overdose of the drug and the occurrence of unwanted side effects that affect the patient's current health during treatment with Odomzo.
In case the patient accidentally takes an overdose of Nexavar than prescribed and shows some signs of unwanted side effects, it is necessary to take the patient to an emergency immediately at a medical facility to receive medical attention. timely medical support, and help patients overcome emergency situations and ensure safety.
4. Unwanted side effects and some notes when using Odomzo
Odomzo medicine can cause some unwanted side effects during treatment with the drug. However, the extent of the drug reaction may depend on the individual.
Nausea and vomiting may occur with the use of Nexavar. You can tell your doctor to prescribe medication to help control this condition and in addition, the doctor may also prescribe appropriate dietary changes to improve the current condition. For example, the patient should avoid using foods that can aggravate these symptoms such as using foods that are greasy, fatty or have sour spices... Instead, the patient can use Use antacids, saline, and ginger ale to relieve nausea and vomiting. Diarrhea can occur in cancer cases. Therefore, your doctor may prescribe some medications to help relieve diarrhea. In addition, patients should eat low-fiber foods, boiled chicken, white rice, to limit diarrhea. In addition, patients should avoid raw vegetables, whole grain breads, cereals ... The soluble fiber in some liquid foods can help reduce diarrhea. This includes apple sauce, bananas, canned fruit, boiled potatoes, or products made with oatmeal, cream of rice, cream of wheat, potato chips. And patients should drink from 8 to 10 glasses of non-alcoholic, caffeinated water every day to limit dehydration. The patient is always tired. After cancer treatment, patients always feel exhausted and this condition takes a long time to improve. Therefore, patients need to adjust as well as plan long-term rest, and at the same time save energy for important activities. In addition, the patient can do exercise to combat fatigue by walking, relaxing... Anemia with low red blood cell count in the blood. Red blood cells carry oxygen to the body's tissues. But when the red blood cell count drops, the body can feel tired and weak. In addition, the patient also feels shortness of breath, chest pain... If the red blood cell count is too low, the patient needs a blood transfusion. Reduces appetite. Diet plays an important role in disease prevention and patient care. Cancer treatment can affect a person's appetite. In some special cases, the main side effect of cancer treatment can make it difficult for patients to eat and drink. Therefore, patients can apply to eat small meals and divide them into many meals, need to provide enough useful nutrients for the body. Adding flavor-enhancing foods helps to stimulate the patient's eating better. Kidney problems can occur with the use of Odomzo, including increased creatinine levels. Therefore, patients need to monitor blood tests along with signs such as decreased urine so that medical assistance can be timely. Muscle problems You may experience muscle spasms and pain while using Odomzo. These signs also indicate a serious muscle condition - rhabdomyolysis and can lead to kidney failure. In case the patient has severe symptoms or pain and muscle spasms, dark urine or decreased urine output, it is necessary to notify the doctor immediately for a timely treatment plan. Loss or thinning of the scalp or loss of body hair. Your hair may become thinner and more prone to breakage starting two to three weeks after treatment with the drug. In some cases, it is possible to lose hair on the whole body, including pubic hair, underarm hair, legs, eyelashes, nose... High blood sugar levels. Odomzo can cause blood sugar levels to rise, so patients need to regularly monitor blood sugar levels to avoid uncontrolled blood sugar fluctuations. Patients may experience pancreatic symptoms such as bloating, indigestion, fatty stools, abdominal pain, weight loss... When these symptoms occur, the patient should immediately notify the doctor treating Odomzo medicine. contains the active ingredient sonidegib 200mg in the form of tablets. The drug is indicated in the treatment of basal cell carcinoma. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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Reference source:.oncolink.org
