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Sonidegib is a product used to treat a certain type of skin cancer (basal cell carcinoma). In July 2015, the US FDA (Food and Drug Administration) approved sonidegib (Odomzo®; Novartis, New Jersey, USA) for the treatment of adult patients with basal cell carcinoma. in situ progression (BCC). Read more to understand more about the uses, indications and precautions when using Sonidegib.The European Commission approved the use of sonidegib for basal cell carcinoma in August 2015. In June 2016, sonidegib was approved for marketing in Switzerland for the treatment of adults with advanced basal cell carcinoma. The drug is also approved in Australia. Additional regulatory submissions are being reviewed by health authorities worldwide.
1. How to use sonidegib
Sonidegib is used to treat a certain type of skin cancer (basal cell carcinoma).Carefully read the Medication Guide provided by your doctor or pharmacist before starting sonidegib and each time restarting a new dosing cycle. If you have any questions about the ingredients or how to use the medicine, talk to your doctor.
The medication is to be taken by mouth as directed by your doctor, usually once daily on an empty stomach, at least 1 hour before or 2 hours after a meal. Use the medicine regularly to get the most benefit from it. To help yourself remember when to take your medicine, take it at the same time each day.
Do not increase your dose or use this medicine more often or for longer than prescribed. The patient's condition will not improve any faster and the risk of side effects will increase.
Tell your doctor if your condition does not improve or if it gets worse.
Thuốc sonidegib được sử dụng để điều trị một loại ung thư da nhất định (ung thư biểu mô tế bào đáy)
2. Possible drug interactions and side effects
2.1. Drug interactions Before taking sonidegib, tell your doctor or pharmacist if you are allergic to it; or if they have any other allergies. This product may contain inactive ingredients, which may cause allergic reactions or other problems. Talk to your treating doctor for more details.Before using this medicine, the patient should also provide complete information about his medical history as well as information about all the products he is taking (including prescription drugs, non-medication drugs). prescriptions, dietary supplements and herbal products).
Do not donate blood while taking this medicine and for a minimum of 20 months after stopping treatment. This will prevent your blood from being passed on to pregnant women.
Older adults may be more sensitive to the side effects of sonidegib. The drug can also stop normal bone growth and affect maximum height if the subject is a child or adolescent.
The drug is not recommended for use during pregnancy. It can harm an unborn baby. Talk to your doctor about using reliable forms of birth control (such as condoms, birth control pills) before starting to use them.
Currently, scientists have not been able to prove whether the drug passes into breast milk in nursing mothers. To minimize the possible risk to the infant, breast-feeding while using this medicine and for 20 months after the last dose of this medicine is not recommended. Please consult your doctor before breast-feeding.
Drug interactions can change the way a drug works or increase the risk of serious side effects. It should be noted that in this article we do not cover all possible drug interactions. Before use, the patient will have to provide information about all the drugs he is taking during this period, including prescription and over-the-counter medicines, supplements and herbs. . Do not start, stop, or change the dose of any medicine without your doctor's approval.
Other drugs may affect how sonidegib is removed from your body, which may affect how sonidegib works. Examples include azole antifungals (such as itraconazole, ketoconazole), efavirenz, modafinil, nefazodone, HIV protease inhibitors (such as ritonavir, saquinavir), rifamycins (such as rifabutin), St. John's wort, medicine used to treat seizures (such as carbamazepine, phenytoin), telithromycin. In addition, sonidegib may also interact with certain other medicines such as:
Atazanavir Certain medicines for fungal infections such as fluconazole , posaconazole and voriconazole Diltiazem Erythromycin Modafinil Nefazodone Rifampin Saquinavir Stomach acid blockers such as cimetidine, famotidine, ranitidine or omeprazole
Thuốc Sonidegib không được khuyến khích sử dụng trong thời kỳ đang mang thai
Do not become pregnant while taking this medicine or for 20 months after stopping it. Women of childbearing potential will need to have a negative pregnancy test before starting this medicine. Women should inform their doctor if they want to become pregnant or think they may be pregnant. This medicine can cause serious birth defects or death to an unborn baby. Talk to your healthcare professional or pharmacist for more information. Do not breastfeed an infant while taking this medicine or for 20 months after stopping it.
Men should not have children while taking this medicine. Men must use condoms during sex with women while taking this medicine and for 8 months after you stop taking this medicine. A condom is required even if you have had a vasectomy. Contact your doctor immediately if your partner becomes pregnant. Do not donate sperm while taking this medicine and for at least 8 months after you stop taking this medicine.
In addition, there are side effects that patients should report to their doctor or healthcare professional as soon as possible: signs and symptoms of muscle injury such as dark urine, difficulty urinating or change in the amount of urine, unusual weakness or fatigue, muscle pain or pain in one side or back. Side effects usually do not require medical attention, however, if these side effects do not go away or become even more severe, immediately notify the treating physician:
Diarrhea Changes in taste Hair loss Pain head Itching Loss of appetite Nausea Vomiting Abdominal pain Fatigue Unexplained weight loss This list may not be descriptive of all side effects. Talk to your doctor for a list of possible side effects from taking the medication.
Tiêu chảy là một trong các tác dụng phụ thường gặp khi sử dụng thuốc Sonidegib
3. Dosage and storage of drugs
3.1. Dosage If someone has overdosed and has severe symptoms such as fainting or difficulty breathing, call 911 immediately. If not, call the center for disease control right away.Do not share this medicine with other medicines.
Lab tests and other medical tests (such as pregnancy test, kidney/liver function, creatine kinase levels, complete blood count, blood glucose) should be done first when patients start taking this medicine and while they are taking it.
If the patient misses a dose, skip the missed dose and continue taking it the next day. Do not try to take an extra dose to make up for the missed dose.
3.2. Storage of the drug Store at room temperature, away from light and moisture. Do not store in the bathroom. Keep all medications out of the reach of children and pets.
Do not flush medication down the toilet or down the drain unless instructed to do so. Dispose of this product appropriately when it has expired or is no longer needed. Consult your pharmacist or local waste disposal company.
Sonidegib is a drug that has the ability to target proteins in cancer cells and stop cancer cells from growing. It is used to treat basal cell carcinoma, a type of skin cancer. In addition, the drug can also be used for other purposes depending on different treatment regimens. Before using the drug, the doctor will carefully investigate some of the patient's health problems such as a history of muscle disorders, unusual or allergic reactions to sonidegib, other drugs, supplements or herbs. , the patient's pregnancy and lactation status....
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References: webmd.com, my.clevelandclinic.org, dermnetnz.org,
