Chuyên viên y tế, Tiến sĩ Nguyễn Văn Tình

TS Nguyễn Văn Tình gia nhập Vinmec năm 2017 với vai trò Nghiên cứu viên tại VNC TBG&CNG VRISG sau đó làm việc tại CARA. T.S nhận bằng thạc sĩ Sinh Học Biển tại Trường Đại học Chosun và  nhận bằng tiến sĩ Y Sinh tại trường đại học quốc gia Pukyong, Hàn Quốc. TS Tình có gần 10 năm kinh nghiệm trong lĩnh vực nghiên cứu tế bào.

Bài báo khoa học đã được xuất bản:

• Thao, C. T., Van Tinh, N., Ha, L. T. T., Van Phuc, T., & Anh, N. T. (2021). Evaluation of Microbial Contamination Rates in Umbilical Cord Blood Collection and Processing for Biobanking in Vietnam. VNU Journal of Science: Natural Sciences and Technology, 37(3).

• Nguyen, M. T., Ngo, Q. V., Nguyen, H. T., Pham, Q. M., Dinh, T. H., Nguyen, H. T., ... Nguyen V. Tinh, & Nguyen, P. (2021). Osteogenic Activity of Lupeol Isolated from Clinacanthus nutans Lindau: Activity and Mode of Action. Journal of Chemistry, 2021.

• Oh, G. W., Nguyen, V. T., Heo, S. Y., Ko, S. C., Kim, C. S., Park, W. S., ... & Jung, W. K. (2020). 3D PCL/fish collagen composite scaffolds incorporating osteogenic abalone protein hydrolysates for bone regeneration application: in vitro and in vivo studies. Journal of Biomaterials Science, Polymer Edition, 1-17.

• Nguyen, P. H., Nguyen, V. T., Chu, T. T., Truong, L. H., Do, T. T. H., Nguyen, T. D., ... & Nguyen, L. T. (2020). Factors Affecting Human Umbilical Cord Blood Quality Before Cryopreservation: The Importance of Birth Weight and Gestational Age. Biopreservation and Biobanking, 18(1), 18-24.

• Nguyen, V. T., Ko, S. C., Oh, G. W., Heo, S. Y., & Jung, W. K. (2019). Effects of Psidium guajava leaf extract on apoptosis induction through mitochondrial dysfunction in HepG2 cells. Microbiology and Biotechnology Letters, 47(1), 43-53.

• Chu Thị Thảo, Thân Thị Trang Uyên, Nguyễn Đắc Tú, Nguyễn Hoàng Phương, Bùi Việt Anh, Nguyễn Văn Tình*, Phân tích các yếu tố liên quan đến chất lượng đơn vị tế bào gốc máu cuống rốn thu thập và xử lý tại bệnh viện đkqt vinmec năm 2017. Tạp chí y học Việt Nam tập 467 tháng 5-số đặc biệt 2018

• Nguyen, V.T., Ko, S.C., Heo, S.J., Kang, D.H., Oh, C., Kim, K.N., Jeon, Y.J., Kim, Y.M., Park, W.S., Choi, I.W. and Park, N.G., 2018. Ciona intestinalis calcitonin-like peptide promotes osteoblast differentiation and mineralization through MAPK pathway in MC3T3-E1 cells. Process Biochemistry, 67, pp.127-138.

• Nguyen V.T., Ko S.C., Oh G.W., Heo S.Y., Jeon Y.J., Park W.S., Choi I.W., Choi S.W., Jung W.K., Anti-inflammatory effects of sodium alginate/gelatine porous scaffolds merged with fucoidan in murine microglial BV2 cells. International Journal of Biological Macromolecules (Dec., 2016) *NRF

• Chandika P., Ko S.C., Oh G.W., Heo S.Y., Nguyen V.T., Jeon Y.J., Lee B., Jang C.H., Kim G.H., Park W.S., Chang W.S., Choi I.W., Jung W.K., Fish collagen/ alginate/ chitooligosaccharides integrated scaffold for skin tissue regeneration application. International Journal of Biological Macromolecules. 81 504-513 (Nov., 2015). * MIBC/NRF

• Oh G.W., Ko S.C., Heo S.Y., Nguyen V.T., Kim G.H., Jang C.H., Park W.S., Choi I.W., Qian Z.J., Jung W.K., A novel peptide purified from the fermented microalga Pavlova lutheri attenuates oxidative stress and melanogenesis in B16F10 melanoma cells. Process Biochemistry 50(8) 1318-1326 (Aug., 2015) * KIMST / NRF

• Nguyen V.T., Qian Z.J., Lee B., Heo S.J., Kim K.N., Jeon Y.J., Park W.S., Choi I.W., Jang C.H., Ko S.C., Park S.J., Kim Y.T., Kim G.H., Lee D.S., Yim M.J., Je J.Y., Jung W.K., Fucoxanthin derivatives from Sargassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-kB and MAPKs in human fibrosarcoma cells. Algae 29(4) 355-366 (Dec., 2014) * KIMST/NRF

• Nguyen V.T., Lee J.S., Qian Z.J., Li Y.X., Kim K.N., Heo S.J., Jeon Y.J., Park W.S., Choi I.W., Je J.Y., Jung W.K., Gliotoxin isolated from marine fungus Aspergillus sp. Induced apoptosis of human cervical cancer cell and human chondrosarcoma cell. Marine Drugs 12(1) 69-87 (Jan., 2014) * NRF / IPET

• Nguyen T.H.M, Qian Z.J., Nguyen V.T., Choi I.W., Heo S.J., Oh C.H., Kang D.H., Kim, G.H., and Jung W.K., Tetrameric peptide purified from biodiesel by-products of Nannochloropsis oculata induces osteoblastic differentiation through MAPK and Smad pathway on MG-63 and D1 cells. Process Biochemistry 48 1387-1394 (Sep., 2013) * IPET/NRF

• Nguyen V.T., Qian Z.J., Ryu B.M., Kim K.N., Kim D.K., Kim Y.M., Jeon Y.J., Park W.S., Choi I.W. Je J.Y., Jung W.K., Matrix metalloproteinases (MMPs) inhibitory effects of an octameric oligopeptide isolated from abalone Haliotis discus hannai. Food Chemistry 141 (1) 503-509 (Nov., 2013)   * IPET/RIS

• Nguyen V.T., Qian Z.J., Jung, W.K., Abalone (Haliotis discus hannai) intestine digests with different molecule weights inhibit MMP-2 and MMP-9 expression in human fibrosarcoma cells. Fisheries & Aquatic Sciences 15(2) 137-143 (Jun., 2012) * IPET/ RIS / Wando

• Nguyen V.T., Qian Z.J., Jung, W.K., Matrix Metalloproteinase: Inhibitory Effect of Marine Substances on MMP-2 and MMP-9. J. Chosun Natural Science 4 255-264 (Dec., 2011) * IPET/ NRF/ KETEP

Bằng sáng chế:

• Korean patent 10-2011-0092951 (Submitted; 2011.09.15)/ 10-1322478 (Registered; 2013.10.21) Abalone intestine gastro-intestinal digests having effects of inhibiting MMP activity and a pharmaceutical composition containing the same as an active ingredient) MMP활성 억제 효과를 갖는 전복 내장 위장관 소화가수분해물 및 이를 유효성분으로 함유하는 약학 조성물) * IPET

Báo cáo tại hội nghị:

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from biodiesel byproducts of marine algae nannochloropsisoculata. ISGMA 2012 international symposium on green manufacturing and applications. Aug 08-27, 2012, Jeju Island, Korea.

• Van-Tinh Nguyen and Won-Kyo Jung. Effects of gliotoxin isolated from marine fungus Aspergillus sp. on apoptosis in human cervical cancer cell and human chondrosarcoma cell. KSABC 2012 The Korean Society for Applied Biological Chemistry. November 8-10, 2012. Kimdaejung Convention Center, Gwangju, Korea.

• Van-Tinh Nguyen Zhong Ji Qian and Won-Kyo Jung. Apoptosis induction of gliotoxin isolated from marine fungus Aspergillus sp. in human cervical cancer cell and human chondrosarcoma cell in vitro. 1st Symposium on Marine Enzymes and Polysaccharides. Nha Trang, Vietnam 10-17, December 2012: Nha Trang, VAST, 2012. – 87c. Conference hall, NHA NGHI T78 (44, TRAN PHU)

• Van-Tinh Nguyen, Nam Gyu Park and Won-Kyo Jung. Ciona intestinalis calcitonin enhances differentiation and mineralization of osteoblastic MC3T3-E1 cells through MAPK pathway. WAS2015 (Would Aquaculture Society). Jeju, Korea 2015.05.26.-30

• Van-Tinh Nguyen and Won-Kyo Jung. Anti-inflammatory effects of fucoidan added with Sodium alginate/gelatine 3D scaffolds in BV2 microglial cells. ICCFB2015 (The international conference on chemical engineering, food and biotechnology). 2015.10.30.-10.31. Ho chi minh city, Vietnam

• Van-Tinh Nguyen and Won-Kyo Jung. On the characterization of fucoidan on sodium alginate/gelatine scaffolds for anti-inflammation in neuroscience. 5th Global Pharmaticists Annual Meeting in Brisbane, Australia (2016.07.14-16)

• Van-Tinh Nguyen, Zhong-Ji Qian, Wong-Kyo Jung. Inhibition MMP-2 and MMP-9 Activity of Different Molecule Weight Fractions by Membrane System from Haliotis discus hannai in the HT1080 Cells. 2011 International Symposium & Annual Meeting of the KSABC. October, 20-22, 2011. ICC Jeju, Korea.

• Van-Tinh Nguyen, Zhong-Ji Qian, Wong-Kyo Jung. Anticoagulant activity of sulfated hydroxyethyl chitooligosaccharide cascade via antithrombin activation. 2011 International Conference on Food Factors. November 20- 23, 2011. 4F, No.20,Ln.128, Jingye 1st Rd., Taipei 10462, Taiwan.

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. Effects of gliotoxin isolated from marine fungus Aspergillus sp. on apoptosis in human cervical cancer cell and human chondrosarcoma cell. IBS 2012: International Biotechnology Symposium & Exhibition. September 2012, Daegu, Korea.

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. An oligopeptide from abalone Haliotis discus hannai inhibits MMP-2 and MMP-9 expression through NF-kB activation in human fibrosarcoma cells. FSAK 2012: Fisheery Sciences Association of Korea. November, 16, 2012. Busan, Korea.

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. Purification of peptide from abalone haliotis discus hannai, which inhibits MMP-2 and MMP-9 expression through NF-kB activation in human fibrosarcoma cells. 1st Symposium on Marine Enzymes and Polysaccharides. Nha Trang, Vietnam 10-17, December 2012: Nha Trang, VAST, 2012. – 87c. Conference hall, NHA NGHI T78 (44, TRAN PHU)

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. Apoptotic cell death induced by gliotoxin in human cervical cancer cell and human chondrosarcoma cell. 10AFAF 2013: 10th Asian Fisheries and Aquaculture Forum. 2013.04.30- 2013.05.04. The Ocean Resort Hotel, Yeosu, Korea.

• Van-Tinh Nguyen, Zhong Ji Qian, Won Kyo Jung. Fucoxanthin derivatives inhibit MMP-2 and MMP-9 expression in human fibrosarcoma cells via down-regulation of NF-кB. 10AFAF 2013: 10th Asian Fisheries and Aquaculture Forum. 2013.04.30- 2013.05.04. The Ocean Resort Hotel, Yeosu, Korea.

• Van-Tinh Nguyen and Won-Kyo Jung* Migration-inhibitory effects of cis isomers of fucoxanthin isolated from sargassum siliquastrum in human fibrosarcoma cells. Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Annual Conference (TEMRIS-AP 2014) 2015.09.246.-27. EXCO, Daegu, Korea

• Van-Tinh Nguyen*,Seok Chun Ko, and Won-Kyo Jung . A pentameric peptide isolated from marine microalgae Pavlova lutheri inhibit migration by suppression MMP-2 and -9 expressions in human fibrosarcoma cells. WAS2015 (Would Aquaculture Society) Jeju, Korea 2015.05.26.-30

• Van-Tinh Nguyen, Il-Whan Choi and Won-Kyo Jung. Matrix metalloproteinases (MMPs) inhibitory effects of an octameric oligopeptide isolated from abalone Haliotis discus hannai. IAS2015 (International Abalone Symposium) 2015.10.05-10. Yeosu, Korea

• Van-Tinh Nguyen, Won-Kyo Jung. Anti-inflammatory effects of fucoidan added with Sodium alginate/gelatine 3D scaffolds in BV2 microglial cells. IASE (International symposium on advanced engineering). 2015.10.22-24. Busan, Korea

• Van-Tinh Nguyen, Nam Gyu Park and Won-Kyo Jung. Calcitonin-like peptide from Ciona intestinalis enhances osteoblastic differentiation and mineralization through MAPK pathway in MC3T3-E1 cells. IASE (International symposium on advanced engineering). 2015.10.22-24. Busan, Korea

• Van-Tinh Nguyen and Won-Kyo Jung. Apoptosis induced by methanolic extracts from leaves of Psidium guajava in human hepatoma HepG2 cells by mitochondrial dysfunction. ICCFB2015 (The international conference on chemical engineering, food and biotechnology). 2015.10.30.-10.31. Ho Chi Minh city, Vietnam

• Van-Tinh Nguyen and Won-Kyo Jung. Structure and characterization of PCL/IGDP 3D scaffolds for potential bone tissue engineering applications. KTERMS, Korea (2016.06.10-11)

• Van-Tinh Nguyen and Won-Kyo Jung. Preparation and characterization of scaffold from PCL-IGDP-Collagen and PCL-IGDP-Alginate for bone tissue regeneration. TERMIS-EU 2017 Conference, 26 – 30 June 2017, Conference Center, Davos, Switzerland. Theme "Personalised Therapies for Regenerative Medicine"

• 16. Van Nguyen, T., Hoang Nguyen, P., Thi Chu, T., Dac Nguyen, T., Thi Trang Than, U., Viet Bui, A., ... & Thanh Nguyen, L. (2019). Factors affecting human umbilical cord blood quality prior to cryopreservation: The importance of birth weight and gestational age. Stem Cells Translational Medicine, 8, S28-S28.

Đề tài và dự án nghiên cứu:

• IPET “R&D for Tissue Regenerative Scaffold applied with Marine Bioactive substances.

• The next generation MarineBio21 planning committee for Korea Institute of Marine Science & Technology Promotion (KIMST)

• The New & Renewable Energy of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Knowledge Economy (No. 20103020090020), and by the Technology Development Program for Fisheries, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea. This research was also financially supported by a research grant (PE98472) from Korea Ocean Research & Development Institute.

• Technology Development Program for Fisheries, Ministry for Food, Agriculture, Forestry and Fisheries, and a grant from the Korean Ministry of Knowledge and Economy through the Program for the Regional Innovation System (RIS). It was also supported by Wando-County Program for R&D Services, Wando-gun, Jeonnam, Republic of Korea.

• Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2013R1A1A1A05013577), and also supported by grant from Marine Technology Application Program (PJT200673) and Marine Biotechnology Program (20150220) Funded by Ministry of Oceans and Fisheries, Republic of Korea.

• Fishery Commercialization Technology Development Program, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea (Wando). It was also supported by Wando-County Program for R&D Services, Wando-gun, Jeonnam, Republic of Korea through the Program for the Regional Innovation System (RIS). It was also supported by Wando-County Program for R&D Services, Wando-gun, Jeonnam, Republic of Korea.