Uses of Temobela

Temobela belongs to a group of anti-cancer and immune-systemic drugs that are used to treat neuroblastoma. Let's learn about Temobela drug information through the article below.

Temobela medicine is made in the form of capsules, with the main ingredient being Temozolomide 5mg. Temozolomide is a derivative of imidazotetrazin. At physiological pH, pharmacologically inactive Temozolomide is hydrolyzed to the active Monomethyl triazeno imidazol carboxamine (MTIC). MTIC acts on multiple phases of the cell cycle, causing cytotoxicity by alkylation at the O6 and N7 positions of guanine in DNA. The subsequent progressive cytotoxic injury is also thought to be related to the aberrant repair of methyl radicals.

Temobela drug is used in the treatment of the following cases:
Glioblastoma multiforme; Regressive or progressive malignant glioblastoma; Metastatic melanoma; Children over 3 years of age with recurrent or progressive glioma. Do not use Temobela in the following cases:
Hypersensitivity to Temozolomide or Dacarbazin (DTIC); Pregnant or lactating women; Severe marrow failure.

Dosage of Temobela drug depends on each case:
Adults with glioblastoma multiforme:
Combination phase: 75mg/m2/day for 42 days, combined with radiation therapy (60Gy, using 30 segments), then use Temozolomide as an adjunct for 6 cycles. Adjuvant phase: Cycle 1: 150mg/m2/day for 5 days, followed by 23 days of no treatment, cycle 2 - cycle 6: 200mg/m2/day for the first 5 days of the cycle if no toxicity occurs count. Adults with recurrent or progressive malignant glioma, or metastatic melanoma and children over 3 years of age with recurrent or progressive glioma:
Without chemotherapy: 200mg/m2/ days for 5 days for a 28-day cycle; If chemotherapy: 150mg/m2/time/day. If no toxicity, cycle 2: 200mg/m2/time/day. Can be used for up to 2 years; Dosage: Take the tablet whole with water, at least 1 hour before eating.

When using Temobela, patients may experience some of the following undesirable effects:
Anorexia, nausea, vomiting and constipation; Fatigue, headache, dizziness, insomnia, decreased concentration and hair loss; Decrease in the number of white blood cells, red blood cells, and platelets. When using Temobela, if the patient experiences any serious side effects, stop taking the drug and contact the treating doctor or immediately go to the nearest medical center for timely treatment.

When using Temobela concurrently may interact with some of the following drugs:
Valproic acid reduces the clearance of Temozolomide, increases the concentration of the drug in the blood plasma. Dexamethasone, Carbamazepine, Prochlorperazine, Phenytoin, Ondansetron, Phenobarbital, H2-receptor antagonists did not affect the clearance of temozolomide. Temozolomide may increase the effects of Natalizumab. The combination of Temozolomide and Clozapine should be avoided because of the increased risk of agranulocytosis. Trastuzumab may also increase the effects of temozolomide. Echinacea reduces the effects of Temozolomide.

When using Temobela, patients should pay attention in the following cases:
Should take the whole pill, do not chew or open the capsule. Food can reduce absorption of the drug, so it should be taken on an empty stomach. Do not open the capsule, if the drug is damaged, avoid the powder inside contact with the skin and mucous membranes; Avoid inhalation of powder, rinse with water if powder gets into eyes and nose. If the patient vomits after taking the drug, the second dose should not be used on the same day. This medicine may cause fatigue and drowsiness, which may affect the ability to drive or use machines. Drugs used in chemotherapy can reduce the number of blood cells. Leukopenia can increase the risk of infection, decrease in red blood cell count can cause anemia, and thrombocytopenia can cause clotting disorders. Therefore, patients need to be tested to monitor blood cell counts regularly during treatment with this medicine. The drug can be toxic to an unborn baby. Women of childbearing potential should use effective contraception to prevent pregnancy during treatment. The drug can harm sperm in men, leading to infertility. The methods of storing sperm samples should be discussed with the patient prior to treatment for future use. During treatment and for 6 months thereafter, the patient should use effective methods of contraception. The drug can also affect fertility in women. Such effects should therefore be discussed with the patient prior to initiating treatment. Above is all information about Temobela drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Temobela is a prescription drug, patients absolutely must not buy and treat at home because they may experience unwanted side effects.