Uses of Makrodex

Each Makrodex 150mg tablet has the main ingredient Roxithromycin 150mg and excipients just enough. Roxithromycin is a semi-synthetic antibiotic belonging to the macrolide group. Roxithromycin is highly concentrated in macrophages and polymorphonuclear leukemic cells, and the intracellular concentration of Roxithromycin is greater than that of extracellular fluid. Roxithromycin enhances the adhesion and chemical function of this cell, when infection occurs, increases phagocytosis and lysis of bacteria.
At plasma concentrations at recommended therapeutic doses, roxithromycin has been shown to be active against the following bacteria: Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydia sp and Ureaplasma urealyticum. Roxithromycin has been shown to be active against quite susceptible microorganisms such as Haemophilus influenzae and Staphylococcus.
Specific effects of Roxithromycin: Roxithromycin can kill many types of bacteria, especially in the uterus, lungs, prostate, sinuses,... because Roxithromycin reaches high concentrations in these locations.
Indications : Makrodex 150mg medicine is used in the treatment of:
Urinary tract infections - genital: Prostatitis, urethritis, metritis, vaginitis, salpingitis, especially caused by Chlamydia infection ; Skin and soft tissue infections: Boils, boils, folliculitis, impetigo, pyoderma, erysipelas, infectious mouth ulcers, infectious cystitis; Infections in the mouth; Ear - nose - throat infections: Sinusitis, pneumonia, bronchitis, tonsillitis, otitis media, esophagitis. Contraindications : Do not use Makrodex for the following cases :
Patients with a history of hypersensitivity to antibiotics of the macrolide group ; Do not use roxithromycin concomitantly with ergotamine-type vasoconstrictor compounds; Do not use roxithromycin and other macrolides in patients receiving terfenadine or astemizol due to the risk of life-threatening arrhythmias; Macrolides should not be used in combination with cisapride due to the risk of severe arrhythmias.

How to use: Makrodex 150mg is made in the form of tablets, so patients take it orally. Use the drug with water, avoid drinking with beer, wine, coffee or some other stimulants.
Dosage:
For adults: Daily dose is 150mg, taken 2 times a day before meals, should not be used for more than 10 days. Treatment should be continued for at least 2 days after symptom relief. Treatment with drugs for at least 10 days in case of urinary tract infection, streptococci infection, vaginitis - cervicitis, use the drug for up to 4 weeks; Children: Usual dose: 5 - 8 mg/kg/day, divided into 2 times; By weight: From 6-11kg: 25mg, used 2 times/day; From 12 - 23kg: 50mg, used 2 times / day; From 24 - 40kg: 100mg, used 2 times/day; Makrodex tablets should not be given to children under 4 years of age. People with severe liver failure: It should be noted that the dose must be reduced by half compared to the normal dose; Patients with renal impairment: Patients with renal impairment do not need to change the usual dose of the drug. It should be noted: The above drug dosage is for reference only, patients need to strictly follow the instructions of the doctor or pharmacist to have an effective dose.
Overdose: In cases of drug overdose Makrodex can be gastric lavage to remove the remaining drug in the stomach. Attention should be paid to symptomatic treatment as required. There is currently no specific antidote to the drug.

Some undesirable effects that patients may encounter when using Makrodex are:
Common: Epigastric pain, nausea, vomiting, diarrhea; Uncommon: Hypersensitivity reactions: Urticaria, angioedema, rash, purpura, anaphylaxis, bronchospasm; Central nervous system: Headache, dizziness, loss of smell and/or taste, paresthesias; Increase in antibiotic-resistant bacteria, superinfection; Rare: Increased serum liver enzymes, symptoms of pancreatitis (very rare), cholestatic hepatitis. Patients need to inform the doctor about the unwanted effects encountered when using Makrodex for timely handling instructions.

Some notes and cautions patients need to remember before and while using Makrodex 150mg are:
Care should be taken when using Makrodex for patients with impaired liver function, children under 6 months old; No need to adjust the dose of Makrodex for elderly subjects and patients with impaired renal function; Makrodex should be used during pregnancy only when clearly needed, although there is no evidence that roxithromycin causes birth defects; Roxithromycin is excreted in breast milk in very low concentrations. Even so, Makrodex should not be used while breastfeeding, unless the benefits outweigh the risks and the patient has received the consent of the doctor; During the treatment with Makrodex, patients need to be especially careful when driving or operating machinery because the drug can cause symptoms such as: dizziness, headache, dizziness.

Drug interactions can change the effectiveness of some drugs or increase unwanted effects. Therefore, the patient should inform the doctor about the drugs/pharmaceuticals he is taking and the medical history of himself and his family.
Some drug interactions Makrodex and other forms of interaction should be noted:
Co-administration of Roxithromycin with one of the following drugs: Terfenadine, astemizol, cisapride has the potential to cause serious cardiac arrhythmias. Therefore, should not be used in combination with these drugs to treat the disease; Makrodex has no significant interactions with carbamazepine, warfarin, cyclosporin and oral contraceptives; Makrodex causes a slight increase in cyclosporin or theophylline plasma concentrations but does not require a change in the usual dose; Makrodex may increase serum concentrations of unbound disopyramide; Makrodex should not be combined with bromocriptin because roxithromycin increases the plasma concentration of bromocriptin. During treatment with Makrodex, patients and family members should pay attention to listen to and follow the instructions of a specialist doctor to achieve the highest efficiency. In addition, to prevent consequences due to unwanted effects, patients should promptly notify their doctor if they experience any unusual symptoms.
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