Diprospan side effects

In the treatment of osteoarthritis diseases, Diprospan is quite commonly used for acute and chronic osteoarthritis that responds to corticosteroids. So what is the effect of the full Diprospan drug?

Diprospan is prepared in the form of a solution for injection of 5+2mg/ml with the main ingredients:
Betamethasone dipropionate: 5mg; Betamethasone sodium phosphate: 2mg. Diprospan is a combination of betamethasone esters with anti-inflammatory, anti-rheumatic, anti-allergic effects, especially used for corticosteroid-responsive diseases. Diprospan is quickly absorbed after injection and has a long-lasting effect because betamethasone dipropionate is weakly soluble in water, becoming a reserve for the body to absorb gradually, helping patients control the disease in a certain time. Diprospan can be injected with a fine needle.

2.1. Indications Patients are prescribed Diprospan in cases of acute or chronic inflammatory disease that responds to corticosteroids, specifically:
Musculoskeletal and soft tissue diseases: rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, bursitis epidemic , coccyx pain , radiculitis , sciatic nerve pain , torticollis , bony prominence... Skin diseases: Atopic dermatitis, neuritis, urticaria, diabetic fat necrosis, alopecia, psoriasis, cystic acne... Allergic diseases: Asthma, angioedema, allergic rhinitis, dust/pollen allergy, insect stings... Dermatomyositis, lupus erythematosus. In addition, Diprospan is also indicated in cases of childhood leukemia, genitourinary-adrenal syndrome, colitis,...
2.2. Contraindications For patients with systemic fungal infections, patients who are sensitive to any of the ingredients are advised not to use Diprospan.

Diprospan is administered intramuscularly for systemic effects. In some cases, Diprospan is injected directly into soft tissues when indicated, intra-articular, peri-articular, intra-articular, local injection in some inflammatory and cystic diseases of the legs... Diprospan is not recommended. intravenously or subcutaneously. Before injecting Diprospan, it is necessary to use strict aseptic techniques.
Systemic use: Initially 1-2 ml, deep intramuscular injection, Diprospan can be combined with 1% or 2% Procaine HCl in a syringe (however, Diprospan is rarely used in combination with an anesthetic agent. in place). The dose and interval between doses of Diprospan depend on the severity of the disease and the response to treatment, with severe diseases such as lupus erythematosus or asthma a starting dose of 2ml can be used. Intra-articular injection: Inject large joints from 1 - 2 ml of Diprospan, medium joints from 0.5 - 1ml, small joints from 0.25 - 0.5ml; In acute bursitis under the deltoid muscle, under the apex of the shoulder, the elbow and in front of the kneecap, the doctor will inject 1-2ml of Diprospan into the bursa to relieve pain and restore movement for the patient in the next few days. few hours. Then treat chronic bursitis at a lower dose when acute symptom control is achieved. Can relieve pain, reduce pain and reduce stiffness in rheumatoid arthritis, osteoarthritis in 2-4 hours after injecting 0.5 - 2 ml of Diprospan medicine into the joint, the time of remission can be 4 weeks or than; In dermatological conditions that may respond to Diprospan, the recommended intradermal dose of Diprospan is 0.2 ml/cm2 and the total dose administered at all sites should not exceed 1 ml per week; Subserosal bursitis can be controlled by injecting Diprospan 0.25ml each time and 2 times in a row. This can help relieve symptoms of stiffness in the big toe, crooked toes and arthritis in gout quickly. The recommended dose of Diprospan with a dose interval of 1 week:
Inflammation of the bursa under the hard or soft callus: dose 0.25 - 0.50ml; Bursitis under the calcaneus: 0.5ml dose; Bursitis caused by stiffness of the big toe: 0.5ml dose; Bursitis caused by 5 crooked toes: 0.5ml dose; Joint capsule: dose 0.25 - 0.5ml; Pain in the bones of the feet: dose 0.25 - 0.5ml; Peri-tendonitis: 0.5ml; Inflammation of the membrane surrounding the cubital bone: 0.5ml; Acute gouty arthritis: 0.5 - 1ml. After a good response, the appropriate maintenance dose should be determined by reducing the dose of Diprospan in small increments at appropriate intervals until the lowest dose that maintains a clinical response is achieved. If the patient is exposed to a stressful environment, the dose of Diprospan can be increased.
If using Diprospan for children, it is necessary to carefully monitor the child, avoid exposing the child to sources of infection because during the use of the drug, the immune system will be weakened. This can affect the child's growth rate and inhibit endogenous corticosteroid production.

Undesirable effects of Diprospan drugs are directly related to the time and dose of the drug. The side effects of Diprospan are usually relieved when the dose is reduced or the drug is stopped. Some possible side effects of Diprospan include:
Water and electrolyte disturbances; Affects muscle and bone system: myasthenia gravis, reduced muscle mass, osteoporosis, spine fracture...; Progressive gastric ulcer causing gastrointestinal bleeding, pancreatitis, esophagitis; Slow wound healing, thin skin, skin atrophy, appearance of petechiae and ecchymosis, erythema, increased sweating, urticaria, angioedema; Convulsions, increased intracranial pressure, major depression, personality changes, insomnia; Menstrual disorders , growth retardation in children; Risk of diabetes, hypoglycemia in diabetic patients; Cataracts, bulging eyes, increased intraocular pressure; Some cases of hypersensitivity can cause reactions like anaphylaxis, hypotension. Except for severe overdoses of Diprospan, most acute glucocorticoid overdoses are not life-threatening. Diprospan can cause eye side effects if taken in excess or for a long time.

Do not inject Diprospan into a vein or under the skin; Diprospan contains water-soluble ingredients, so it disperses quickly from the injection site and can cause systemic effects; Diprospan should be used with caution in patients with idiopathic thrombocytopenic purpura; Corticosteroids such as Diprospan should be injected deep into the large muscle mass to avoid tissue atrophy at the injection site; When Diprospan is injected into damaged soft tissues and in joints, it can cause systemic effects and local effects; Diprospan should not be injected into an infected joint, and should be treated with appropriate antibiotics when an infection is diagnosed; Diprospan should not be injected into unstable joints, infected areas or into the area between the vertebrae. The repeated injection of Diprospan into the joint in osteoarthritis can increase joint degeneration, do not inject directly into the tendon because it will cause sprain; After injecting Diprospan into the joint, the patient should avoid excessive joint movement; Corticosteroids can mask some new infections during treatment, reduce resistance and cannot localize the infection; Prolonged use of corticosteroids such as Diprospan can lead to subcapsular cataracts (especially in children), glaucoma, damage to the optic nerve, increased secondary bacterial or fungal eye infections; Drug-induced secondary adrenocortical insufficiency may result from stopping corticosteroids too quickly; The effect of Diprospan is increased in patients with hypothyroidism or cirrhosis. It can be said that Diprospan helps to solve many diseases of bones and joints. However, when used in the wrong way, this drug can cause drug interactions, reducing the effectiveness of treatment. Therefore, patients need to follow the doctor's prescription when taking diprospan.