Bristopen: Uses, dosages and side effects

Article written by Pharmacist MSc. Pham Thi Kim Dung - Faculty of Pharmacy - Vinmec Times City International General Hospital

Bristopen is an antibiotic, used to kill bacteria, indicated in the treatment of respiratory, bone, urinary tract infections... Here are the usage, dosage and notes while using it. drug use.

Bristopen is a brand name drug with the active ingredient being the sodium salt of Oxacillin, manufactured by Bristol Myers Squibb. Oxacillin is an antibiotic belonging to the penicillin group, belonging to the beta-lactam group, with bactericidal action.

Bristopen (Oxacillin) is indicated for the treatment of infections caused by penicillinase-resistant strains of Staphylococci, including respiratory, skin, bone, joint, urinary tract infections, meningitis, and bacteremia.
Restrictions on indications: Oxacillin should not be used in infections with penicillin G susceptible organisms.
Off-label indications of the drug are catheter-related bacteremia, skin necrosis and soft tissue, wound infection.

Bristopen is available for intravenous, intramuscular and infusion administration.
To reduce the risk of thrombosis and allergic reactions at the injection site, the drug should be infused slowly and avoid the risk of extravasation.
Dosage depends on site of infection and disease state. With severe Staphylococci infections, bone infections, severe meningitis, the duration of the drug may be 1-2 weeks or longer.
When calculating the dose, doctors and pharmacists should keep in mind that the drug contains a significant amount of sodium salts, especially when used in patients with heart failure. No dose adjustment is required in patients with hepatic and renal impairment.

Uncommon side effects:
Gastrointestinal: diarrhea, enteritis

On the liver: hepatotoxicity, increased liver enzyme AST (aspartate aminotransferase) On the kidney: acute interstitial nephritis, acute tubular disease

Contraindicated in patients who are allergic to any of the penicillins.
The patient needs to stop taking the medicine and tell the doctor if there is an unusual reaction to the drug such as diarrhea, abdominal pain,... Inform the doctor about the drugs being used before the doctor prescribes For women with Pregnancy and lactation should inform the doctor about the status of pregnancy and lactation. If taking the drug long-term, the patient should be monitored for liver enzymes, kidney function, total urinalysis, blood creatinine level. For any questions or concerns about this drug, you can contact the hotline of Vinmec International General Hospital. This is a prestigious medical facility, with a team of experienced, highly qualified doctors and nurses with academic degrees and high degrees in the industry. Here, not only gathers a team of famous domestic doctors but also international doctors, bringing the most effective and new treatment regimens today.

Modern medical equipment system, fully equipped, comfortable facilities, clean environment, meeting the strict requirements of the Ministry of Health to help patients feel secure during treatment. To register for examination and treatment at Vinmec International General Hospital, you can contact the nationwide Vinmec Health System Hotline, or register online HERE.