The application of radioactive isotopes in treatment is becoming increasingly popular because of its high efficiency, short treatment time but still ensuring safety. Using radioactive isotopes in treatment, also known as radiotherapy, is the use of ionizing radiation of radioactive isotopes to attack diseased cells and tissues.

Pain from cancer metastasis to bone is a chronic pain condition with complex pathogenesis and impact on physical, psychological and daily activities of cancer patients. Over the years, many different modalities of pain treatment for bone metastases have been tested and certain achievements have been achieved. These methods are presented in turn as follows: