Women in pre-menopause and menopause have many changes in endocrine hormones, in which the severe decrease in estrogen is a key factor that puts women at high risk of depression.

Congenital hypothyroidism in children is caused by an endocrine disorder that causes a lack or defect in the effects of thyroid hormones. This causes slow physical, mental and motor development in children. If the disease is not detected and treated promptly, children will be at high risk of lifelong dwarfism and mental retardation, even death.