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Question
Hello doctor,
Doctor, I have a question, why does nitroglycerin not work for unstable angina? Thank you.
Anonymous customer
Answer
Answered by Master, Doctor Do Nguyen Thuy Doan Trang - Head of Extracorporeal Circulation Team - Cardiovascular Center, Vinmec Central Park International General Hospital.
Hello,
With the question "Why does nitroglycerin not work for unstable angina?", the doctor would like to answer as follows:
Nitroglycerin is an organic nitrate, when entering the body converted to nitric oxide (NO). The drug is mainly used to relieve angina pectoris, in combination with other drugs to treat congestive heart failure, paroxysmal hypertension in surgery.
Although nitroglycerin has vasodilating effects in both arteries and veins, the effect of nitroglycerin is mainly venous vasodilation. Varicose veins help reduce the volume load on the heart, reduce the strain on the ventricular walls, reduce the work of the heart, reduce the symptoms of angina secondary to ischemia. The vasodilation of the coronary arteries will increase blood flow to the heart, increasing perfusion. However, this effect is less than the effect on the vein, the effect is reduced (tolerance over time).
After administration, the vasodilator effect begins to occur within 1 to 3 minutes, with the maximum effect occurring within 5 minutes. The dose may be repeated every 5 minutes until remission is achieved. If angina persists after three doses, the patient should seek medical attention promptly so as not to lose the “golden time for acute myocardial infarction”
If angina persists after three doses, The patient needs prompt medical attention. Nitroglycerin is eliminated primarily by hepatic metabolism and has a mean half-life of about 2 to 3 minutes. If you still have questions about care and treatment, you can visit a Cardiologist for more detailed advice.
If you still have questions about nitroglycerin, you can go to the hospital of Vinmec Health System for further examination and advice. Thank you for trusting and sending questions to Vinmec. Wish you a lot of health.
Best regards!
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