What is Sumiko 20mg?

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1. What is Sumiko 20mg?

Paroxetin is a selective serotonin reuptake inhibitor, chemically unrelated to the tricyclic, tetracyclic or other antidepressants. Paroxetine is well tolerated when administered orally and undergoes first-pass metabolism by the liver. Steady state drug concentrations reached 7-14 days after treatment and pharmacokinetics remained unchanged throughout the treatment period. Paroxetin is highly bound to plasma proteins (about 95%). The drug can be distributed into breast milk and the fetus in small amounts in test animals. Sumiko 20 mg is indicated for use in the following conditions:
Severe depression. Types of anxiety disorders include social anxiety or other common anxiety disorders Obsessive-compulsive disorder. Panic Disorder Post-Traumatic Stress Disorder.

2. How to use Sumiko 20mg

The drug is taken orally. Patients should take the tablet whole with a sufficient amount of water, without chewing, in the morning and with food. Specific dosages are as follows:
Depression: The recommended dose is 20 mg/day, which may be increased in increments of 10 mg to a maximum of 50 mg daily depending on clinical response. Social phobia and common anxiety disorders: The recommended dose is 20 mg/day. If there is no response after several weeks, the dose may be increased gradually by 10 mg to a maximum of 50 mg/day. Patients should be evaluated at regular intervals for long-term use. Obsessive Compulsive Disorder: The recommended dose is 40 mg daily, the starting dose is usually 20 mg and may be increased in 10 mg increments up to the recommended dose. Some patients achieve therapeutic efficacy at a maximum dose of 60 mg/day. Panic disorder: The recommended dose is 40 mg daily, should be started at 10 mg and may be increased in 10 mg increments up to the recommended dose depending on response Post-Traumatic Stress Disorder : Recommended starting dose 20 mg/day and usually gives a good response in most patients. If the response is inadequate at this dose, the dose may be gradually increased in 10 mg increments depending on the clinical setting, up to a maximum of 50 mg/day. Hepatic or renal impairment: Plasma concentrations of paroxetine are increased in patients with severe renal impairment or severe hepatic impairment. Therefore, a dose lower than the usual recommended dose should be used. Elderly: Plasma concentrations of paroxetine are increased in the elderly. It should be started at 20 mg/day and increased in 10 mg increments to a maximum dose of 40 mg/day depending on response. Children: The use of paroxetine in children is not recommended, as safety and efficacy have not been established.

3. What to do when taking Sumiko drug overdose?

Symptoms of overdose include vomiting, nausea, high fever, and smooth muscle spasms. Usually, the patient will recover without serious sequelae. Cases of coma or electrocardiographic changes have been reported very rarely, but usually occur only when patients are co-administered with paroxetine with other psychoactive drugs.
There is no specific antidote for Paroxetine poisoning. The doctor may prescribe vomiting or gastric lavage, or both. After gastric emptying, the patient may be given 20 to 30 g of activated charcoal every 4-6 hours during the first 24 hours after the overdose. Patients require supportive care with regular monitoring of vital signs.

4. What are the unwanted effects of Sumiko 20mg?

> 10%:
Endocrine: Decreased libido Digestive: Constipation, anorexia, diarrhea, dyspepsia, nausea, nausea Genitourinary: Ejaculation disorders Nervous system: Dizziness, sadness sleep, headache, insomnia Neuromuscular and skeletal: Asthenia, tremor 1 to 10%:
Cardiovascular: Chest pain, hypertension, palpitations, tachycardia, vasodilation Dermatology: Itching, rash skin Endocrine and metabolic: Weight gain Gastrointestinal: Abdominal pain, dyspepsia, flatulence, increased appetite, nausea and vomiting (more often in children and adolescents) Genitourinary system: Dysuria, dysmenorrhea, female genital tract disease, impotence, change in frequency of urination, urinary tract infection, urinary disorder. Nervous system: Abnormal dreams, agitation, amnesia, anxiety, chills, confusion, emotional disturbances, fatigue, euphoria, inattention, coma, irritability, mania, depression myoclonus, myoclonus, anxiety, paresthesia, dizziness, yawning. Neuromuscular and skeletal: Arthralgia, back pain, myalgia, myopathy Ophthalmology: Blurred vision, visual disturbances Respiratory: Oropharyngeal edema, pharyngitis, rhinitis, sinusitis Other: Trauma <1%:
Cardiovascular: atrial fibrillation, bradycardia, ischemia, peripheral edema, phlebitis, syncope, thrombophlebitis. Dermatological: Alopecia, skin ulcers, vesicles, eczema, erythema multiforme, exfoliative dermatitis, maculopapular rash, skin discoloration, photosensitive skin, urticaria Endocrine and metabolic: Amenorrhea: Amenorrhea , dehydration, diabetes mellitus, gout, heavy menstrual bleeding, hirsutism, hypercalcemia, hypercholesterolemia, hyperglycemia, hypocalcemia Digestion: diarrhea, cholelithiasis, colitis, diarrhea bleeding teeth, duodenitis, dysphagia, enteritis, intestinal obstruction, tongue discoloration Genitourinary system: Cystitis, painful urination, epididymitis, mastitis, nocturia, oliguria. Hematologic: Anemia, eosinophilia, hematoma, lymphedema, prolonged bleeding time, thrombocytopenia or thrombocytopenia Liver: Hepatitis, hyperbilirubinemia, elevated liver enzymes, jaundice Hypersensitivity: Angioedema, hypersensitivity reactions, tongue edema Neuromuscular: Ataxia, arthritis, bursitis, dyskinesia, muscle spasms, myelitis, myositis, osteoarthritis, osteoporosis bone , tendinitis Kidney: Hyperuremia, nephritis, nephrolithiasis, polyuria Respiratory: Asthma, bronchitis, dyspnea, nosebleeds, hemoptysis, pneumonia

5. Contraindications to using Sumiko 20mg

Contraindicated to use Sumiko 20 mg in the following cases:
Patients with hypersensitivity to paroxetine or to any of its ingredients. Patients taking monoamine oxidase inhibitors (MAOIs) Used in combination with thioridazine or pimozide

6. Notes when using Sumiko 20mg

Central Nervous System Effects : The drug can cause central nervous system depression, impairing physical or mental abilities. Therefore, patients must be warned when performing tasks that require mental alertness (eg, operating machinery or driving). Paroxetine should not be taken with an MAOI or within 2 weeks of its termination. treatment with MAOIs. Similarly, do not use MAOIs within 2 weeks of stopping paroxetine. Cardiovascular disease: Caution should be exercised when administering Sumiko 20mg to patients with cardiovascular disease. Paroxetine has not been systematically evaluated in patients with a history of myocardial infarction or unstable heart disease. Hepatic impairment: Caution should be taken when administering Sumiko 20mg to patients with impaired liver function. Drug clearance is decreased and plasma concentrations are increased. However, selective serotonin reuptake inhibitors such as paroxetine are considered the safest antidepressants to use for chronic liver disease, because of their relatively few side effects. Renal Impairment: Use with caution in patients with renal impairment, dose adjustment may be required for patients with renal impairment. Seizure Disorders : Use with caution in patients with seizure disorders Pregnancy: animal studies have not shown any harmful effects on the fetus, however, the safety of paroxetine in pregnant women has not been established. Therefore, it is not recommended to use paroxetine in pregnant women, unless the benefits outweigh the risks. Lactation: Due to the potential for serious adverse reactions in the nursing infant, the manufacturer recommends that a decision be made whether to discontinue nursing or to discontinue paroxetine and evaluate the importance of treatment. for the mother. When starting an antidepressant in a nursing patient, paroxetine can be used. However, other drugs should be considered if the patient requires long-term treatment and wishes to become pregnant again. In summary, Sumiko 20mg is an antidepressant and anxiety disorder. The drug can cause many serious side effects. Therefore, patients should not self-medicate, but should consult a medical professional.
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