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Prednisnalo drug helps anti-inflammatory and immunosuppressive in the following cases: Rheumatoid arthritis, vasculitis, lupus erythematosus, bronchial asthma, chronic ulcerative colitis, severe allergies (including anaphylaxis), hemolytic anemia, granulocytopenia. In addition, the drug also supports the treatment of cancers such as lymphoma, prostate cancer, breast cancer, primary nephrotic syndrome.
1. What are the effects of Prednisnalo?
Prednisnalo drug has the main ingredient is 16mg Methylprednisolone, a glucocorticoid with anti-inflammatory, allergic and immunosuppressive effects.
Some typical indications of the drug Prednisnalo:
Abnormalities on the function of the adrenal cortex; Atopic dermatitis, allergic respiratory inflammation, bronchial asthma; Arthritis, rheumatism, rheumatoid arthritis ; Blood diseases (hemolytic anemia, agranulocytosis); Lupus erythematosus ; Severe allergic disease including anaphylaxis, Cancer treatment: Lymphoma, Acute Leukemia, Breast Cancer, Prostate Cancer; Primary nephrotic syndrome.
2. Instructions on how to take Prednisnalo 16
2.1. Dosage for adults Prednisnalo starting dose is usually 4 - 48mg / day, can be used as a single dose or in divided doses depending on the condition:
Multiple sclerosis (multiple sclerosis): Oral 160 mg / day x 1 week , then reduce the dose to 64mg, every 2 days x 1 month; Rheumatoid arthritis: Oral dose starts from 4-6mg/day. In the acute episode, take 16-32mg/day, then gradually reduce the dose; Acute asthma attack: Take 32 - 48mg/day x 5 days. When the acute attack is over, gradually reduce the dose; Primary nephrotic syndrome: Take a starting dose of 0.8 - 1.6mg/kg for 6 weeks, then gradually reduce the dose; Hemolytic anemia: Oral 64mg/day x 3 days. Must be treated for 6-8 weeks; Sarcoid disease: Take 0.8 mg/kg/day for remission. Low maintenance dose 8mg/day. 2.2. Dosage for children Treatment of adrenal insufficiency: Oral 0.117 mg/kg x 3 times/day; Other indications: Oral 0.417 - 1.67 mg/kg x 3.4 times/day.
3. Side effects of Prednisnalo 16
During treatment, patients taking Prednisnalo may experience some side effects such as:
Common side effects: Insomnia, irritability, indigestion, diabetes, joint pain and bleeding orange, cataract, glaucoma; Uncommon side effects: Headache, dizziness, convulsions, psychosis, brain pseudotumor, hallucinations, delirium, edema, increased blood pressure, tissue hyperpigmentation (skin bruising), skin atrophy, syndrome Cushing's syndrome, abdominal distention, peptic ulcer, nausea and vomiting, esophagitis, pancreatitis, muscle weakness, osteoporosis, hypersensitivity reactions. Note: Undesirable effects of Prednisnalo are most common when used in high doses and for a long time. The component Methylprednisolone inhibits prostaglandin synthesis and affects the effects of prostaglandins on the gastrointestinal tract, including inhibiting gastric acid secretion and protecting the gastric mucosa.
4. Note when taking Prednisnalo 16
Prednisnalo is contraindicated in the following cases:
People who are sensitive or allergic to the components of the drug (especially Methylprednisolone); Severe infections (except tuberculous meningitis and septic shock); Skin lesions caused by viruses, fungi or tuberculosis; People who are new to live virus vaccines; Pregnant women; Prednisnalo should be used with caution in the following subjects:
Patients with osteoporosis; Newly connected blood vessels; Have a mental disorder; Stomach ulcer, duodenal ulcer; Patients with diabetes, hypertension, heart failure; Breastfeeding mothers. To avoid undesirable effects, systemic corticosteroids must be used with caution in elderly patients, preferably at the lowest possible dose and for the shortest possible duration. Acute adrenal insufficiency may occur with abrupt discontinuation of Prednisnalo after prolonged treatment or in the presence of stress. When used in high doses, the effectiveness of vaccination may be affected.
Prolonged use of systemic corticosteroids by the mother may lead to a slight decrease in the infant's condition. The use of corticosteroids in pregnant women should carefully weigh the potential benefits against the possible risks to the mother and baby. Corticosteroids are not contraindicated in nursing mothers.
Prednisnalo should be used with caution, because this medicine can cause unwanted effects that affect the ability to drive and use machines.
5. Prednisnalo 16 drug interactions
Methylprednisolone is an inducer of cytochrome P450 enzyme and a substrate of P450 3A4 enzyme, so this drug affects the metabolism of drugs: Cyclosporin, Phenytoin, Erythromycin, Phenobarbital, Ketoconazole, Carbamazepine, Rifampicin.
Phenytoin, Rifampin, Phenobarbital and hypokalemic diuretics may decrease the potency of methylprednisolone in Prednisnalo.
Ingredients Methylprednisolone can cause hyperglycemia, therefore diabetic patients need to take higher insulin doses.
The article has information you need to know about the uses, dosage, and notes before taking Prednisnalo 16. The information is for reference only and to prevent unwanted side effects, patients should take care of themselves. contact and seek the advice and prescription of a qualified medical practitioner.
