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Plerixafor also known as Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in blood cancer patients. Stem cells are then extracted from the blood and transplanted back into the patient.
1. What is Plerixafor? Uses of Plerixafor
What is Plerixafor? Plerixafor is a blood stem cell mobilizer, used to stimulate the release of blood bone marrow stem cells in patients with non-Hodgkin lymphoma and multiple myeloma, to stimulate the immune system. body immunity.
These stem cells will then be collected and used in a transplant to replace blood cells that have been destroyed by chemotherapy or radiation.
2. Dosage of Plerixafor
2.1. How to use This is a medicine used for injection under the skin. Before using, check the quality of the drug by checking the color, see if the drug does not change color or not, if the drug has discoloration, do not use the drug.
Before injecting each dose, the patient should clean the injection site with rubbing alcohol. Change the injection site each time to reduce subcutaneous damage.
Inject Plerixafor subcutaneously as prescribed and directed by your doctor, usually about 11 hours before the dialysis procedure. Dosage is based on the patient's medical condition and weight.
2.2. Pharmacodynamics Following subcutaneous injection, plerixafor is rapidly absorbed and peak concentrations occur 30 minutes to 1 hour after injection. Most of the drug will be metabolized and bound to proteins in the plasma, the remaining few will be in the extracellular space. Then plerixafor is excreted by the kidneys, 70% of the dose is excreted within 24 hours.
3. Side effects when taking Plerixafor
Some common side effects when using the drug that patients should be aware of:
There may be a reaction of diarrhea, nausea, vomiting, flatulence, dizziness, or pain, redness, swelling at the injection site. . According to the study, the number of patients experiencing these symptoms is about 10%, 1% of patients have other reactions: digestive problems and general symptoms such as dizziness, headache and muscle pain. Most of these reactions are mild and will go away in a short time. However, if any of these effects persist or become more severe, tell your doctor right away.
Tell your doctor right away if you have any serious side effects including: left upper abdominal pain, left shoulder pain, fainting, easy bleeding, bruising, rash, itching, swelling ( especially in areas such as face/tongue/throat), dizziness, difficulty breathing.
4. Some important notes before using the drug
Before using plerixafor, tell your doctor or pharmacist if you are allergic to any of its ingredients. Before using this medicine, tell your doctor about any medical conditions you have ever had, especially each condition such as: kidney disease, leukemia, abnormally high neutrophil count. Because the drug causes dizziness and dizziness, the patient should not drive or use machinery until the body feels more awake. Before using medication, tell your doctor about all medicinal products you use (including prescription drugs, over-the-counter drugs, and herbal products). The drug is not for use by pregnant women or those planning to become pregnant. Because Plerixafor can harm an unborn baby. In case a woman is taking Plerixafor, use safe birth control methods. For nursing women, there are currently no studies to prove that the drug can pass into breast milk. But because of the possible risk of adverse effects on the newborn, doctors will advise women who are breastfeeding not to use this medicine.
5. Drug interactions
Drug interactions may change the effect and effectiveness of the drug or may increase the effect of side effects on the body. Some drugs that interact with plerixafor that patients need to be aware of such as: Ciclosporin, Icosapent, Cefotiam, Cefmenoxime, Cefmetazole, Tenofovir disoproxil, Indometacin, Cidofovir... These drugs can reduce the rate of excretion of Plerixafor without causing pain. may lead to a higher serum level.
In summary, Plerixafor is a blood stem cell motivator, used to stimulate the release of blood bone marrow stem cells in patients with non-Hodgkin lymphoma and multiple myeloma, to stimulate the body's immune system.
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Reference source: webmd.com
