What is Parabest 500mg?

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1. What is Parabest 500mg?

Parabest 500mg drug, also known as Parabest Extra 500mg or effervescent Parabest 500mg. This is a product manufactured by Bac Ninh Pharmaceutical Joint Stock Company - Vietnam.
Parabest drug belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs. The drug with 2 main ingredients Paracetamol 500mg and Chlorpheniramine maleate 2mg is used specifically for the treatment of fever, pain relief due to flu, seasonal allergies, runny nose.
The drug is prepared in the form of effervescent tablets packed in a box of 5 blisters x 4 tablets.
Effects of main ingredients:
Paracetamol: This is an analgesic - antipyretic, the drug will act on the thermoregulatory center in the hypothalamus to increase heat loss, lower heat due to vasodilation. At the same time, increasing peripheral blood flow helps to reduce body temperature in people with fever. Paracetamol also reduces pain by raising the pain threshold. Chlorpheniramine maleate: is an antihistamine, through inhibition of H1 receptors to lead to the reduction of edema, urticaria in allergic reactions and anaphylaxis. Chlorpheniramine is an active ingredient that also has anticholinergic effects.

2. Indications and contraindications of Parabest 500mg

2.1. Indications With the use of ingredients, Parabest 500mg is often indicated for pain relief, fever reduction due to flu, runny nose or allergies to the weather.
2.2.Contraindications Parabest 500mg is contraindicated in the following cases:
Do not use Parabest 500mg effervescent drug for people with a history of allergy or hypersensitivity to one of the drug's ingredients. Patients who are being treated with MAOIs or have used MAOIs within the previous 2 weeks should not use this medicine. Patients with kidney failure, liver failure also do not use Parabest Extra 500mg because it affects the metabolism and elimination of the drug. Patients with prostate cancer or bladder neck obstruction or narrow-angle glaucoma should not use the drug. Breastfeeding women, infants and premature infants should not take this medicine, as this medicine can pass into breast milk.

3. Dosage – how to use Parabest 500mg

You can refer to the dosage and how to use Parabest 500mg according to the following instructions:
How to use:
Parabest 500mg is prepared in the form of effervescent tablets. Therefore, it should be taken orally. Patients need to mix 1 effervescent Parabest 500mg tablet with about 200ml of boiling water to cool and wait for the effervescent tablet to dissolve completely, then drink.
Dosage:
Adults and children over 12 years old: take 2-4 tablets/day divided into 2 oral doses. Children from 6-12 years old: Take 2 tablets/day divided into 2 doses. The interval between 2 doses is 4-6 hours and the patient should pay attention not to take more than 8 tablets/day. Besides, without the prescription and guidance of the doctor, medical staff is not allowed to take the drug for more than 4 consecutive days.

4. Treatment when missed dose, overdose

If you forget to take a dose, take it as soon as you remember as soon as possible. However, if the missed dose is close to the next dose, skip the missed dose and take the next scheduled dose. Absolutely do not use twice the dose to avoid causing overdose affecting health.
In case of overdose or unusual symptoms, call 911 or go to the nearest medical facility immediately for timely treatment.

5. Parabest 500mg . side effects

During the use of Parabest Extra 500mg, the adverse side effects that patients may experience are as follows:
Related to Paracetamol:
Uncommon: Rash, nausea, vomiting, neutropenia , platelets, whole red blood cells, anemia. Rare: Stevens-Johnson syndrome, toxic skin necrosis syndrome, acute generalized pustular rash. Related to chlorpheniramine:
Common: drowsiness, fatigue, dizziness, headache, psychomotor disturbances, dry mouth, blurred vision, urinary retention, constipation, gastroesophageal reflux. Uncommon: Nausea, vomiting, epigastric pain, diarrhea, arrhythmia, palpitations, rash, bronchospasm, angioedema, anaphylaxis. Rare: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia. Other: Sweating, convulsions, paresthesia, myalgia, extrapyramidal, depression, sleep disturbance, confusion, hypotension, tinnitus, alopecia. When experiencing side effects of the drug, the patient should immediately notify the doctor or pharmacist for advice, appointment and timely treatment.

6. Drug interactions

What is Parabest 500mg and what drugs interact with it? Each main ingredient of the drug will have different drug interactions, namely:
Related to paracetamol:
Taking high doses of paracetamol for a long time will slightly increase the anticoagulant effect of coumarin and indandion derivatives. Concomitant use of phenothiazines and hypothermia in patients may cause severe hypothermia. Anticonvulsants (barbiturates, phenytoin, carbamazepine) induce hepatic microsomal enzymes and may increase the hepatotoxicity of paracetamol. Concomitant use of paracetamol with isoniazid may increase the risk of hepatotoxicity. And Cholestyramine has the ability to reduce the absorption of paracetamol (do not take within 1 hour). In relation to chlorpheniramine:
MAO inhibitors prolong and potentiate the antimuscarinic effects of antihistamines. Tranquilizers or Ethanol may enhance the CNS depressant effects of chlorpheniramine. Chlorpheniramine inhibits the metabolism of phenytoin and can lead to phenytoin toxicity. To ensure safe drug use and avoid drug interactions, patients should list the drugs (including prescription and over-the-counter drugs), dietary supplements, and herbs being used for the doctor to grasp and counseling to avoid drug interactions.

7. Be careful when using Parabest 500mg

During the use of Parabest 500mg, the patient should strictly follow the instructions of the professional. Absolutely do not arbitrarily increase or decrease the dose of the drug to quickly take effect. If the patient has cardiovascular disease, allergies, etc., requiring prolonged use of the drug, please let the doctor know for advice and change the dose accordingly. During treatment, the patient should abstain from foods, alcoholic beverages and stimulants. Absolutely do not stop the dose arbitrarily, before making a decision to stop treatment with the drug, it is necessary to consult the treating doctor. Parabest Extra 500mg should not be used by people who are driving or operating machinery because it affects concentration and nervous system. Store the medicine in a dry place with a temperature below 30 degrees, avoid placing the medicine in a place with direct sunlight or high humidity. Keep the medicine out of sight and reach of small children to prevent children from playing and accidentally ingesting it. For drugs that have expired or are discolored, moldy, or watery, do not use them, but contact your waste disposal company or pharmacist for instructions on how to safely dispose of the medicine.
Hopefully the information in this article has helped everyone know what Parabest 500mg is, its uses, and how to use it. From there, use the right medicine according to the doctor's prescription to increase the effectiveness of the treatment.
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