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Oribier 200mg drug belongs to the group of non-prescription drugs whose main ingredient is N-Acetylcysteine, which is used to dissolve phlegm, support in respiratory diseases, treat ENT diseases and used as a detoxifying dose in some Paracetamol overdose.
1. What is Oribier 200?
Oribier drug has the main active ingredient N-Acetylcysteine, which cuts off the S-S bridges of mucus in the respiratory tract, combined with the cough reflex to help push the sputum out. Therefore, Oribier is often used to support the treatment of respiratory infections with mucus secretions.
In addition, N-Acetylcysteine also has a detoxifying effect on patients with Paracetamol overdose. After entering the body, N-Acetylcysteine is converted into acetylcysteine, which stimulates the liver to synthesize glutathione to maintain or restore the liver's glutathione concentration. This substance is necessary to inactivate the intermediate metabolite of Paracetamol which is hepatotoxic, so it can be used to protect the liver when poisoning is detected early in the first 12 hours.
2. Uses of Oribier
Because of the above effects, Oribier 200mg is often indicated in the following cases:
Diarrhea, support in respiratory diseases, bronchial polycythemia, emphysema; Patients with sinusitis, rhinitis, pharyngitis, otitis media,... Detoxification in cases of Paracetamol overdose. Oribier is used orally with reference doses as follows:
Children under 2 years old: 200mg/day divided into 2 times; Children 2-6 years old: 200mg x 2 times/day; Adults: 200mg x 3 times/day. 3. Some notes when using Oribier 200mg In general, N-Acetylcysteine is a drug with quite wide safety limits, only a few patients have side effects when using such as nausea, vomiting, drowsiness. , headache, tinnitus. The drug is contraindicated in subjects with hypersensitivity to any of the components of the drug, with asthma at risk of developing bronchospasm reactions with all forms of drugs containing N-Acetylcysteine.
In the event of an overdose of N-Acetylcysteine, symptoms resembling anaphylaxis may occur, but in more severe cases hypotension, respiratory depression, rarely fever, chills and bronchospasm. Possible drug interactions when using Oribier include:
Interactions when used with strong oxidizing agents such as metals (iron, aluminum); Do not use concurrently with other cough medicines or drugs that reduce bronchial secretion during the use of N-Acetylcysteine; Incompatible with solutions containing Penicillin, Oxacillin, Amphotericin B, Tetracycline. When using Oribier 200mg, it is necessary to monitor patients with a history of asthma, if there is a phenomenon of bronchospasm, the drug must be stopped immediately and symptomatic treatment with bronchodilators (salbutamol). For those who are not able to spit up sputum, it is necessary to aspirate the sputum to help the patient after taking the medicine.
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